Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Idit Shachar"'
Autor:
Stav Rabani, Emine Gulsen Gunes, Martin Gunes, Bianca Pellegrino, Bar Lampert, Keren David, Raju Pillai, Aimin Li, Shirly Becker-Herman, Steven T. Rosen, Idit Shachar
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114920- (2024)
Summary: Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype. The tumor microenvironment (TME) plays a major regulatory role in TNBC progression and is highly infiltrated by suppressive immune cells that reduce anti-tumo
Externí odkaz:
https://doaj.org/article/07986e34a7fa4417aebf0d3aa8f5f5cf
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Recently, cancer immunotherapy has revolutionized cancer treatment. Various forms of immunotherapy have a manageable safety profile and result in prolongation of overall survival in patients with solid tumors, but only in a proportion of patients. Va
Externí odkaz:
https://doaj.org/article/18a1cfa7eccf4906a45de9636f67d9a2
Autor:
Hadas Lewinsky, Emine G. Gunes, Keren David, Lihi Radomir, Matthias P. Kramer, Bianca Pellegrino, Michal Perpinial, Jing Chen, Ting-fang He, Anthony G. Mansour, Kun-Yu Teng, Supriyo Bhattacharya, Enrico Caserta, Estelle Troadec, Peter Lee, Mingye Feng, Jonathan Keats, Amrita Krishnan, Michael Rosenzweig, Jianhua Yu, Michael A. Caligiuri, Yosef Cohen, Olga Shevetz, Shirly Becker-Herman, Flavia Pichiorri, Steven Rosen, Idit Shachar
Publikováno v:
JCI Insight, Vol 8, Iss 14 (2023)
Externí odkaz:
https://doaj.org/article/fac6727535924d42be070993ae2438ba
Autor:
Ariel Ogran, Tal Havkin-Solomon, Shirly Becker-Herman, Keren David, Idit Shachar, Rivka Dikstein
Publikováno v:
eLife, Vol 11 (2022)
The transformation of normal to malignant cells is accompanied by substantial changes in gene expression programs through diverse mechanisms. Here, we examined the changes in the landscape of transcription start sites and alternative promoter (AP) us
Externí odkaz:
https://doaj.org/article/4a07f29a457d4718a1b3bfb50f6d062c
Autor:
Lihi Radomir, Matthias P. Kramer, Michal Perpinial, Nofar Schottlender, Stav Rabani, Keren David, Anna Wiener, Hadas Lewinsky, Shirly Becker-Herman, Rina Aharoni, Ron Milo, Claudia Mauri, Idit Shachar
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Regulatory B (Breg) cells suppress excessive inflammation primary via the production of interleukin 10 (IL-10). Here the authors show that the function and homeostasis of mouse and human IL-10+ Breg cells are negatively regulated by the cell surface
Externí odkaz:
https://doaj.org/article/9e0225d58b0f4b71aa42bed1e5fd6e18
Autor:
Avital Eisenberg-Lerner, Ron Benyair, Noa Hizkiahou, Neta Nudel, Roey Maor, Matthias P. Kramer, Merav D. Shmueli, Inbal Zigdon, Marina Cherniavsky Lev, Adi Ulman, Jitka Yehudith Sagiv, Molly Dayan, Bareket Dassa, Mercedes Rosenwald, Idit Shachar, Jie Li, Yanzhuang Wang, Nili Dezorella, Suman Khan, Ziv Porat, Eyal Shimoni, Ori Avinoam, Yifat Merbl
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Correct Golgi assembly is important to cellular homeostasis but regulation of its structure under stress remains unclear. Here, the authors identify stress-induced degradation of GM130 by Golgi-localized 26S proteasomes, leading to Golgi dispersal.
Externí odkaz:
https://doaj.org/article/ff1a3445dde44826a238fff8d76ba365
Autor:
Shirly Becker-Herman, Milena Rozenberg, Carmit Hillel-Karniel, Naama Gil-Yarom, Mattias P Kramer, Avital Barak, Lital Sever, Keren David, Lihi Radomir, Hadas Lewinsky, Michal Levi, Gilgi Friedlander, Richard Bucala, Amnon Peled, Idit Shachar
Publikováno v:
PLoS Biology, Vol 19, Iss 3, p e3001121 (2021)
Hematopoietic stem and progenitor cells (HSPCs) are a small population of undifferentiated cells that have the capacity for self-renewal and differentiate into all blood cell lineages. These cells are the most useful cells for clinical transplantatio
Externí odkaz:
https://doaj.org/article/31d2b909abae4ae2830454e4fdbfdedf
Autor:
Hadas Lewinsky, Emine G. Gunes, Keren David, Lihi Radomir, Matthias P. Kramer, Bianca Pellegrino, Michal Perpinial, Jing Chen, Ting-fang He, Anthony G. Mansour, Kun-Yu Teng, Supriyo Bhattacharya, Enrico Caserta, Estelle Troadec, Peter Lee, Mingye Feng, Jonathan Keats, Amrita Krishnan, Michael Rosenzweig, Jianhua Yu, Michael A. Caligiuri, Yosef Cohen, Olga Shevetz, Shirly Becker-Herman, Flavia Pichiorri, Steven Rosen, Idit Shachar
Publikováno v:
JCI Insight, Vol 6, Iss 4 (2021)
Multiple myeloma (MM) is characterized by an accumulation of malignant plasma cells (PCs) within the BM. The BM microenvironment supports survival of the malignant cells and is composed of cellular fractions that foster myeloma development and progre
Externí odkaz:
https://doaj.org/article/d7a411db996948a2b5bdffc9677fbefe
Sulfamate Acetamides as Self-Immolative Electrophiles for Covalent Ligand-Directed Release Chemistry
Autor:
Rambabu N. Reddi, Adi Rogel, Ronen Gabizon, Dattatraya Gautam Rawale, Battu Harish, Shir Marom, Barr Tivon, Yamit Shorer Arbel, Neta Gurwicz, Roni Oren, Keren David, Jingjing Liu, Shirly Duberstein, Maxim Itkin, Sergey Malitsky, Haim Barr, Ben-Zion Katz, Yair Herishanu, Idit Shachar, Ziv Shulman, Nir London
Publikováno v:
Journal of the American Chemical Society. 145:3346-3360
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f436a11b4b6322b7627191f360644f7
https://doi.org/10.1021/jacs.2c08853
https://doi.org/10.1021/jacs.2c08853
Autor:
Tharshika Thavayogarajah, Dzmitry Sinitski, Omar El Bounkari, Laura Torres-Garcia, Hadas Lewinsky, Alexander Harjung, Hong-Ru Chen, Jens Panse, Lucia Vankann, Idit Shachar, Jürgen Bernhagen, Steffen Koschmieder
Publikováno v:
Experimental Hematology. 115:30-43
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of small, mature CD5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c9b5b9848878b44a12c1209e3ba6b7
https://doi.org/10.1016/j.exphem.2022.08.005
https://doi.org/10.1016/j.exphem.2022.08.005