Zobrazeno 1 - 10
of 577
pro vyhledávání: '"Idiotopes"'
Autor:
Eunike McGowan
Providing the best possible patient outcomes for haemolytic disease of the fetus and newborn (HDFN) requires quality laboratory testing to guide clinical management. Laboratory testing shows the risk for HDFN by identifying whether the mother: 1) is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d3a9d1a8518cce2b53753012eb61869
https://doi.org/10.14264/fbab40a
https://doi.org/10.14264/fbab40a
Autor:
Inge Pareyn, Rob Fijnheer, Jan Voorberg, Karen Vanhoorelbeke, Simon F. De Meyer, Marina Biganzoli, Bérangère S. Joly, Flora Peyvandi, Hans Deckmyn, An Sofie Schelpe, Elien Roose, Agnès Veyradier, Ilaria Mancini, Paul Coppo
Publikováno v:
Haematologica
Haematologica, 104(6), 1268-1276. Ferrata Storti Foundation
Haematologica, 104(6), 1268-1276. Ferrata Storti Foundation
In autoantibody-mediated autoimmune diseases, autoantibody profiling allows patients to be stratified and links autoantibodies with disease severity and outcome. However, in immune-mediated thrombotic thrombocytopenic purpura (iTTP) patients, stratif
Autor:
Rune A. Høglund, Robert D. Bremel, E. Jane Homan, Silje Bøen Torsetnes, Andreas Lossius, Trygve Holmøy
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
B cells are important pathogenic players in multiple sclerosis (MS), but their exact role is not known. We have previously demonstrated that B cells from cerebrospinal fluid (CSF) of MS patients can activate T cells that specifically recognize antige
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e857a7df7b20ee831164345e8bdf56
http://hdl.handle.net/10852/84516
http://hdl.handle.net/10852/84516
Autor:
Eric C. Peterson, Andrew T. McGuire, Margaret Goodall, Timothy F. Kowalik, Jeffrey D. Jensen, Celia A. Schiffer, Nese Kurt Yilmaz, Kristina L. Prachanronarong, Brendan J. Hilbert, Robert W. Finberg, Wayne A. Marasco, Quan Zhu, Vinodh B. Kurella, Roy Jefferis, Markus-Frederik Bohn, Jianhua Sui, Shurong Hou, Hatem Zayed, Jennifer P. Wang, Zhen Zhang, Yuval Avnir, Leonidas Stamatatos
Publikováno v:
Cell Reports
Cell Reports, Vol 21, Iss 11, Pp 3243-3255 (2017)
Cell Reports, Vol 21, Iss 11, Pp 3243-3255 (2017)
Summary The heavy chain IGHV1-69 germline gene exhibits a high level of polymorphism and shows biased use in protective antibody (Ab) responses to infections and vaccines. It is also highly expressed in several B cell malignancies and autoimmune dise
Autor:
Hilmar Lemke
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology, Vol 9 (2018)
Antigen determinants (epitopes) are recognized by the combining sites (paratopes) of B and T cell antigen receptors (BCR/TCR), which again express clone-specific epitopes (idiotopes) that can be recognized by BCR/TCR not only of genetically different
Autor:
T. V. Korotaeva
Publikováno v:
Современная ревматология, Vol 9, Iss 4, Pp 13-19 (2016)
The present-day views of the immunogenicity of biological agents (BAs) used to in the treatment of psoriasis and psoriatic arthritis are analyzed. The immunogenicity of these medicaments is noted to depend on their molecular structure, individual pat
Autor:
Rune A. Høglund, Andreas Lossius, Jorunn N. Johansen, Jane Homan, Jūratė Šaltytė Benth, Harlan Robins, Bjarne Bogen, Robert D. Bremel, Trygve Holmøy
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 8 (2017)
Frontiers in Immunology, Vol 8 (2017)
Memory B cells acting as antigen-presenting cells are believed to be important in multiple sclerosis (MS), but the antigen they present remains unknown. We hypothesized that B cells may activate CD4+ T cells in the central nervous system of MS patien
Autor:
Rosa Catera, Hirotomo Nakahara, Xiao-Jie Yan, Matthew N. Alder, Max D. Cooper, Brantley R. Herrin, Nicholas Chiorazzi
Publikováno v:
Cancer Immunology Research. 1:223-228
For antigen recognition, lampreys use leucine-rich repeats (LRR) instead of immunoglobulin V-(D)-J domains to generate variable lymphocyte receptors (VLR) of three types: VLRA, VLRB, and VLRC. VLRB-bearing lymphocytes respond to immunization with pro
Autor:
Hilmar Lemke
Publikováno v:
Critical reviews in immunology. 36(1)
The clone-specific or idiotypic characters of B as well as T cell antigen receptors (BCRs/TCRs) are associated with (1) the third-complementarity-determining regions (CDR3s) that are created during V(D)J recombination (they scarcely occur in antibody
Autor:
Eric C. Peterson, Yuval Avnir, Aimee St. Clair Tallarico, Margaret Goodall, Subhabrata Biswas, Jennifer R. Brown, Quan Zhu, Vinodh B. Kurella, Stacey M. Fernandes, Madhura M. Panditrao, Jianhua Sui, Yanyan Wang, Wayne A. Marasco, De-Kuan Chang, Xueqian Wang, Jiusong Sun, Roy Jefferis
Publikováno v:
mAbs
In 10-20% of the cases of chronic lymphocytic leukemia of B-cell phenotype (B-CLL), the IGHV1-69 germline is utilized as VH gene of the B cell receptor (BCR). Mouse G6 (MuG6) is an anti-idiotypic monoclonal antibody discovered in a screen against rhe