Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Idilio González"'
Autor:
Pedro Dorado, Idilio González, Adrián LLerena, Fernando de Andrés, Luis R Calzadilla, Eva M Peñas-Lledó, María Eugenia G Naranjo
Publikováno v:
OMICS: A Journal of Integrative Biology. 21:17-26
A long-standing question and dilemma in precision medicine is whether and to what extent genotyping or phenotyping drug metabolizing enzymes such as CYP2D6 can be used in real-life global clinical and societal settings. Although in an ideal world usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ea23a6017325722fb93a51cfd30f42
https://doi.org/10.1089/omi.2016.0166
https://doi.org/10.1089/omi.2016.0166
Autor:
Mónica, Sánchez Autet, Marina, Garriga, Francisco Javier, Zamora, Idilio, González, Judith, Usall, Leticia, Tolosa, Concepción, Benítez, Raquel, Puertas, Belén, Arranz
Publikováno v:
Adicciones. 30(4)
Alcohol use disorders (AUD) are 2 times higher among psychiatric patients than in the general population. The under-recognition of this dual diagnosis can entail several negative outcomes. Early assessment with a screening tool like the CAGE question
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3a2932092eb226ad4388e3a7964339c0
https://pubmed.ncbi.nlm.nih.gov/28492957
https://pubmed.ncbi.nlm.nih.gov/28492957
Publikováno v:
Pharmacogenomics. 10:1111-1120
Aims: A lower serotonin/higher dopamine tone in CYP2D6 poor metabolizers (PMs) versus extensive metabolizers (EMs) has been postulated, which is consistent with our prior research showing behavioral traits related to anxiety and impulsivity in PMs. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdda9538503472e5040c89ead831d4e3
https://doi.org/10.2217/pgs.09.75
https://doi.org/10.2217/pgs.09.75
Autor:
Adrián LLerena, Idilio González, Bárbaro Pérez, Eva M Peñas-Lledó, Mayra Alvarez, Pedro Dorado
Publikováno v:
Pharmacogenomics. 9:833-840
Objectives: Our group has previously show that interindividual variability in CYP2D6 hydroxylation capacity was related to personality differences in cognitive social anxiety. Thus, we aimed to analyze whether this relationship between personality an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c096e3ba4b3e8793910c00246a285ed
https://doi.org/10.2217/14622416.9.7.833
https://doi.org/10.2217/14622416.9.7.833
Autor:
Francisco Javier Zamora, Raquel Puertas, Belén Arranz, Mónica Sánchez Autet, Marina Garriga, Judith Usall, Idilio González, Leticia Tolosa, Concepción Benítez
Publikováno v:
Adicciones. 30:251
Alcohol use disorders (AUD) are 2 times higher among psychiatric patients than in the general population. The under-recognition of this dual diagnosis can entail several negative outcomes. Early assessment with a screening tool like the CAGE question
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0281f7f23e0713748999f8a52e2b3eb2
https://doi.org/10.20882/adicciones.885
https://doi.org/10.20882/adicciones.885
Publikováno v:
Medicina Clínica. 128:772-774
Fundamento y objetivo La capacidad metabolica del CYP2D6 presenta polimorfismo genetico. A partir del calculo del indice metabolico (IM) urinario de un farmaco test como la debrisoquina se ha demostrado la existencia de 2 fenotipos metabolicos: metab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e826d30283bed8af111e4420fb4dda8
https://doi.org/10.1157/13106328
https://doi.org/10.1157/13106328
CYP2D6 -1584CG promoter polymorphism and debrisoquine ultrarapid hydroxylation in healthy volunteers
Autor:
Adrian, Llerena, Pedro, Dorado, Ronald, Ramírez, Luis R, Calzadilla, Eva, Peñas-Lledó, Mayra, Álvarez, María E G, Naranjo, Idilio, González, Bárbaro, Pérez, Nicolás, González-Vacarezza
Publikováno v:
Pharmacogenomics. 14(16)
Background & aim: The CYP2D6 -1584C>G polymorphism (rs1080985) has been identified as a major factor for CYP2D6 expression and function, with the mutant -1584G promoter type being consistently associated with significantly greater expression than -15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9036725aeafd12e9d38241b0f9f6a14a
https://pubmed.ncbi.nlm.nih.gov/24279852
https://pubmed.ncbi.nlm.nih.gov/24279852
Autor:
Mercedes Alvarez, Idilio González, Luis R Calzadilla, Pedro Dorado, Bárbaro Pérez, J. Cobaleda, Eva M Peñas-Lledó, Adrián LLerena
Publikováno v:
The pharmacogenomics journal. 14(3)
The aims of this study were to evaluate the diclofenac metabolism in Hispanics from Cuba and Spain and its relation to ethnicity, CYP2C9 genotypes and environmental factors. Diclofenac hydroxylation capacity (concentration ratios of diclofenac/metabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc969036954bd7cec77c51280143c511
https://pubmed.ncbi.nlm.nih.gov/23959274
https://pubmed.ncbi.nlm.nih.gov/23959274
Autor:
Pedro Dorado, Eva M Peñas-Lledó, María Eugenia G Naranjo, Alfredo de la Rubia, Idilio González, Adrián LLerena, Antonio P. González, Fernando de Andrés
Publikováno v:
Drug Metabolism and Drug Interactions. 27
Background Aripiprazole (ARI) is an antipsychotic drug that is metabolized to dehydroaripiprazole (DARI) by CYP2D6. Because of the large interindividual variability in ARI and DARI plasma concentrations, therapeutic drug monitoring may be of use in p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::714c26d5ca892866ab0e8dd1e6d946f9
https://doi.org/10.1515/dmdi-2012-0016
https://doi.org/10.1515/dmdi-2012-0016
Autor:
Mercedes Alvarez, Adrián LLerena, Bárbaro Pérez, Eva M Peñas-Lledó, Idilio González, Pedro Dorado, R. Ramírez, Luis R Calzadilla
Publikováno v:
The pharmacogenomics journal. 12(2)
CYP2D6 genotype and debrisoquine metabolic ratio (MR) were analyzed in 133 Nicaraguan Mestizos (NMs) and 260 Cubans divided into Cuban Mestizos (CMs) and White Cubans (WCs). The frequencies of poor metabolizers (MR⩾12.6) were 6% in NMs, 3.9% in CMs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708ae1cd87d6d2f40d33c34936d6f0f5
https://pubmed.ncbi.nlm.nih.gov/21135868
https://pubmed.ncbi.nlm.nih.gov/21135868