A pharmacological toolkit for human microglia identifies Topoisomerase I inhibitors as immunomodulators for Alzheimer's disease.

Autor: Haage V; Center for Translational & Computational Neuroimmunology, Neuroimmunology Division, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States., Tuddenham JF; Center for Translational & Computational Neuroimmunology, Neuroimmunology Division, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States.; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, United States., Comandante-Lou N; Center for Translational & Computational Neuroimmunology, Neuroimmunology Division, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States., Bautista A; Center for Translational & Computational Neuroimmunology, Neuroimmunology Division, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States., Monzel A; Department of Psychiatry, Division of Behavioral Medicine, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, USA., Chiu R; Center for Translational & Computational Neuroimmunology, Neuroimmunology Division, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States., Fujita M; Center for Translational & Computational Neuroimmunology, Neuroimmunology Division, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States., Garcia FG; Center for Translational & Computational Neuroimmunology, Neuroimmunology Division, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States., Bhattarai P; Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States., Patel R; Department of Pathology and Cell Biology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States., Buonfiglioli A; Department of Psychiatry, Icahn School of Medicine, 1460 Madison Avenue, New York, NY, 10029, United States., Idiarte J; Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States., Herman M; Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States., Rinderspacher A; Department of Medicine, Columbia University, New York, NY 10032, United States., Mela A; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Zhao W; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, United States., Argenziano MG; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA., Furnari JL; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA., Banu MA; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA., Landry DW; Department of Medicine, Columbia University, New York, NY 10032, United States., Bruce JN; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA., Canoll P; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Zhang Y; Center for Translational & Computational Neuroimmunology, Neuroimmunology Division, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States., Nuriel T; Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States., Kizil C; Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States., Sproul AA; Department of Pathology and Cell Biology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States., de Witte LD; Department of Psychiatry, Icahn School of Medicine, 1460 Madison Avenue, New York, NY, 10029, United States., Sims PA; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, United States., Menon V; Center for Translational & Computational Neuroimmunology, Neuroimmunology Division, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States., Picard M; Department of Psychiatry, Division of Behavioral Medicine, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, USA.; Department of Neurology, H. Houston Merritt Center, Columbia Translational Neuroscience Initiative, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, USA.; New York State Psychiatric Institute, New York, USA.; Robert N Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA., De Jager PL; Center for Translational & Computational Neuroimmunology, Neuroimmunology Division, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, United States.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Feb 06. Date of Electronic Publication: 2024 Feb 06.