Zobrazeno 1 - 10
of 1 886
pro vyhledávání: '"Idebenone"'
Autor:
Øystein K. Jørstad, Stine Skaar, Harald Strand, Oddveig Røsby, Ruth Therese Brokstad, Pål A. Rønning
Publikováno v:
Case Reports in Ophthalmology, Vol 15, Iss 1, Pp 513-517 (2024)
Introduction: Leber hereditary optic neuropathy (LHON) is a mitochondrial disorder that typically presents with painless, central visual loss, hyperaemia of the optic nerve head, and peripapillary telangiectasias. Most LHON cases are due to one of th
Externí odkaz:
https://doaj.org/article/cfd7a363bdf34452903bb36ae887ac00
Autor:
Hongliang Qiu, Sihui Huang, Yuting Liu, Libo Liu, Fengming Guo, Yingying Guo, Dan Li, Xianfeng Cen, Yajie Chen, Meng Zhang, Yan Che, Man Xu, Qizhu Tang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 6, Pp 2581-2597 (2024)
Doxorubicin (DOX)-mediated cardiotoxicity can exacerbate mortality in oncology patients, but related pharmacotherapeutic measures are relatively limited. Ferroptosis was recently identified as a major mechanism of DOX-induced cardiotoxicity. Idebenon
Externí odkaz:
https://doaj.org/article/dfe8996f856d4f6dbc399a77398b3539
Autor:
Sam Zarbakhsh, Parisa Hayat
Publikováno v:
Cell Journal, Vol 26, Iss 3, Pp 194-201 (2024)
Objective: Schwann cells are the main cells for myelination and regeneration of peripheral nerves. Idebenone is asynthetic antioxidant used to treat central nervous system diseases. The aim of the study is to determine whether idebenonecan protect Sc
Externí odkaz:
https://doaj.org/article/bc6a39be0ee544eea1a7c21063b7a5ca
Akademický článek
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Autor:
Chenyu Wu, Ximiao Chen, Xiaoying Zhao, Yu Chen, Hao Zhou, Yuxin Deng, Chenchao Li, Yang Huang, Weiyang Gao, Di Zhang, Hongwei Ouyang, Xiaolei Zhang
Publikováno v:
Materials & Design, Vol 242, Iss , Pp 112972- (2024)
Spinal cord injury (SCI) is a severe central nerve diseases which lacks effective of treatment. Oxidative stress is a major pathological factor for SCI. It may induce mitochondrial damage, which further lead to ferroptosis and apoptosis in neural cel
Externí odkaz:
https://doaj.org/article/3e9127c741624984a12651a074487d2d
Publikováno v:
Iraqi Journal of Pharmaceutical Sciences, Vol 33, Iss 1 (2024)
Idebenone, a synthetic analogue of ubiquinone (Co-Q10), is used for the treatment of Leiber’s hereditary optic neuropathy. Although it is almost completely absorbed from GIT, its extensive rate of metabolism makes its oral bioavailability less than
Externí odkaz:
https://doaj.org/article/dce38f5ef36f479380666a279d61d879
Autor:
Sonia Trombino, Roberta Sole, Federica Curcio, Rocco Malivindi, Daniele Caracciolo, Silvia Mellace, Dino Montagner, Roberta Cassano
Publikováno v:
Gels, Vol 10, Iss 8, p 485 (2024)
Melanoma is one of the most aggressive forms of skin cancer, which is characterized by metastasis and poor prognosis due to the limited effectiveness of current therapies and the toxicity of conventional drugs. For this reason and in recent years, on
Externí odkaz:
https://doaj.org/article/8dbd41eacb6d47bab356ebff56b2278e
Publikováno v:
Клинический разбор в общей медицине, Vol 4, Iss 7, Pp 50-58 (2023)
Cerebrovascular diseases are among the most frequent nosological forms of modern neurology. One of the most important components of their clinical picture is cognitive impairment. At the same time, the most frequent is the development of mild and mod
Externí odkaz:
https://doaj.org/article/9e43bc7b14664f66b01826cab17488df
Publikováno v:
مجلة كلية الطب, Vol 65, Iss 3 (2023)
Background Idebenone is an extensively metabolized drug with poor water solubility that is used to treat Leiber’s hereditary optical neuropathy. Objective This study aims to prepare idebenone nanoemulsion as a poloxamer-based nasal gel to overcom
Externí odkaz:
https://doaj.org/article/4074e40b415b41e088eb713e80cbf083
Autor:
Emanuele Porru, Filomena Piro, Rossana Comito, Anastasiia Mosendz, Elirosa Minniti, Matteo Conti, Alessandra Stancari, Francesco Saverio Violante
Publikováno v:
Separations, Vol 10, Iss 9, p 517 (2023)
Idebenone (IDB) (2,3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinone) is a compound synthesized in the early 1980s. Initially developed for the treatment of cognitive disturbances and Alzheimer’s disease, IDB is now studied for Friedreich
Externí odkaz:
https://doaj.org/article/5d4b921cb0c14d529dcfa57b9f5fc9f7