Zobrazeno 1 - 10 of 23 pro vyhledávání: '"Ida Ricciardelli"'
2
The Landscape of Early Clinical Gene Therapies outside of Oncology
Autor: Ida Ricciardelli, Timothy M. Clay, Steven J. Howe, Alastair Morrison, Takis Athanasopoulos, Laurent Jespers, David J. Dow, Aurore Saudemont, Marie L. Davies, Miguel Calero-Garcia, Laure Rittié
Publikováno v: Mol Ther
The field of cell and gene therapy (GT) is expanding rapidly and there is undoubtedly a wave of enthusiasm and anticipation for what these treatments could achieve next. Here we assessed the worldwide landscape of GT assets currently in early clinica
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ea5206348a6b933160ca405b99d892
https://europepmc.org/articles/PMC6822232/
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3
Gene-corrected human Munc13-4–deficient CD8+ T cells can efficiently restrict EBV-driven lymphoproliferation in immunodeficient mice
Autor: Geneviève de Saint Basile, Persis Amrolia, Amandine Durand, Julie Rivière, François-Loïc Cosset, Ida Ricciardelli, Chantal Lagresle-Peyrou, Isabelle André-Schmutz, Tayebeh Soheili, Marina Cavazzana, Anne-Céline Derrien, Els Verhoeyen
Publikováno v: Blood. 128:2859-2862
To the editor: Familial hemophagocytic lymphohistiocytosis type 3 (FHL3) is a hyperinflammatory disease caused by mutations in the UNC13D gene (coding for the Munc13-4 protein); FHL3 accounts for 30% to 35% of FHL cases.[1][1] In cytotoxic T cells (C
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e4f08751472b2d3d7499b32480a7c4
https://doi.org/10.1182/blood-2016-07-729871
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4
Cord blood T cells mediate enhanced antitumor effects compared with adult peripheral blood T cells
Autor: Kimberly Gilmour, Persis Amrolia, Prashant Hiwarkar, Paul Veys, Aurore Saudemont, Sergio A. Quezada, Ida Ricciardelli, Waseem Qasim
Publikováno v: Blood. 126:2882-2891
Unrelated cord blood transplantation (CBT) without in vivo T-cell depletion is increasingly used to treat high-risk hematologic malignancies. Following T-replete CBT, naive CB T cells undergo rapid peripheral expansion with memory-effector differenti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82beb648e00c64e4b0c7dba4f3877a9d
https://doi.org/10.1182/blood-2015-06-654780
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5
Transfer of gene-corrected T cells corrects humoral and cytotoxic defects in patients with X-linked lymphoproliferative disease
Autor: Neelam, Panchal, Ben, Houghton, Begona, Diez, Sujal, Ghosh, Ida, Ricciardelli, Adrian J, Thrasher, H Bobby, Gaspar, Claire, Booth
Publikováno v: The Journal of Allergy and Clinical Immunology
Background X-linked lymphoproliferative disease 1 arises from mutations in the SH2D1A gene encoding SLAM-associated protein (SAP), an adaptor protein expressed in T, natural killer (NK), and NKT cells. Defects lead to abnormalities of T-cell and NK c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2e14627954608633d614b1756020921b
https://pubmed.ncbi.nlm.nih.gov/29705247
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6
T-cell gene therapy for perforin deficiency corrects cytotoxicity defects and prevents hemophagocytic lymphohistiocytosis manifestations
Autor: Sujal, Ghosh, Marlene, Carmo, Miguel, Calero-Garcia, Ida, Ricciardelli, Juan Carlos, Bustamante Ogando, Michael P, Blundell, Axel, Schambach, Philip G, Ashton-Rickardt, Claire, Booth, Stephan, Ehl, Kai, Lehmberg, Adrian J, Thrasher, H Bobby, Gaspar
Publikováno v: The Journal of Allergy and Clinical Immunology
Background Mutations in the perforin 1 (PRF1) gene account for up to 58% of familial hemophagocytic lymphohistiocytosis syndromes. The resulting defects in effector cell cytotoxicity lead to hypercytokinemia and hyperactivation with inflammation in v
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::14690577636e3f6a19b988c293ec89cf
https://pubmed.ncbi.nlm.nih.gov/29355678
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8
Towards gene therapy for EBV-associated posttransplant lymphoma with genetically modified EBV-specific cytotoxic T cells
Autor: Martin Pule, Adrian J. Thrasher, Persis Amrolia, Michael P. Blundell, Jennifer Brewin, Ida Ricciardelli
Publikováno v: Blood. 124:2514-2522
Epstein-Barr virus (EBV)-associated posttransplant lymphoma (PTLD) is a major cause of morbidity/mortality after hematopoietic stem cell (SCT) or solid organ (SOT) transplant. Adoptive immunotherapy with EBV-specific cytotoxic lymphocytes (CTLs), alt
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb5ee975dbf3ae865833436caa2d49bc
https://doi.org/10.1182/blood-2014-01-553362
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9
Simultaneous Generation of Multivirus-specific and Regulatory T Cells for Adoptive Immunotherapy
Autor: Persis Amrolia, Arjan C. Lankester, Gertjan Lugthart, Sarah J. Albon, Michel G.D. Kester, Pauline Meij, Ida Ricciardelli
Publikováno v: Journal of Immunotherapy, 35(1), 42-53
Previous studies have established that adoptive immunotherapy with donor-derived virus-specific T cells can prevent/treat viral complications post-stem cell transplant and regulatory T cells show promise as inhibitors of graft-versus-host disease. On
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2b393ea2d1c0db91ee59ff0cfe8934d
https://doi.org/10.1097/cji.0b013e31823569e2
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