Výsledky vyhledávání - "Ida Perrotta"

Akademický článek

The redox-active defensive Selenoprotein T as a novel stress sensor protein playing a key role in the pathophysiology of heart failure

Autor: Anna De Bartolo, Teresa Pasqua, Naomi Romeo, Vittoria Rago, Ida Perrotta, Francesca Giordano, Maria Concetta Granieri, Alessandro Marrone, Rosa Mazza, Maria Carmela Cerra, Benjamin Lefranc, Jérôme Leprince, Youssef Anouar, Tommaso Angelone, Carmine Rocca

Publikováno v: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-21 (2024)

Abstract Maladaptive cardiac hypertrophy contributes to the development of heart failure (HF). The oxidoreductase Selenoprotein T (SELENOT) emerged as a key regulator during rat cardiogenesis and acute cardiac protection. However, its action in chron

Externí odkaz: https://doaj.org/article/897b28636dbf40f0a12e6a868b0d04ba

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Akademický článek

Atherosclerosis: From Molecular Biology to Therapeutic Perspective 3.0

Autor: Ida Perrotta

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 8, p 6897 (2023)

Atherosclerosis is a multifactorial chronic disease triggered and sustained by different risk factors such as dyslipidemia, hypertension, diabetes mellitus (DM), smoke, elevated homocysteine, and hormones [...]

Externí odkaz: https://doaj.org/article/d4bf55c1a98941969b6c8465b58b9ac9

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Akademický článek

Palmitate-Induced Cardiac Lipotoxicity Is Relieved by the Redox-Active Motif of SELENOT through Improving Mitochondrial Function and Regulating Metabolic State

Publikováno v: Cells, Vol 12, Iss 7, p 1042 (2023)

Cardiac lipotoxicity is an important contributor to cardiovascular complications during obesity. Given the fundamental role of the endoplasmic reticulum (ER)-resident Selenoprotein T (SELENOT) for cardiomyocyte differentiation and protection and for

Externí odkaz: https://doaj.org/article/70ffa1561c694353854bbb4eb175853b

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Akademický článek

CD38-Induced Metabolic Dysfunction Primes Multiple Myeloma Cells for NAD+-Lowering Agents

Publikováno v: Antioxidants, Vol 12, Iss 2, p 494 (2023)

Cancer cells fuel growth and energy demands by increasing their NAD+ biosynthesis dependency, which therefore represents an exploitable vulnerability for anti-cancer strategies. CD38 is a NAD+-degrading enzyme that has become crucial for anti-MM ther

Externí odkaz: https://doaj.org/article/0e796c050e73475a981a9b6091ebf662

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Akademický článek

Atherosclerosis: From Molecular Biology to Therapeutic Perspective 2.0

Autor: Ida Perrotta

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 23, p 15158 (2022)

Atherosclerosis is a chronic inflammatory disease of large- and medium-sized arteries involving aberrant immune–inflammatory responses, dysfunctional molecular pathways, and impaired tissue repair mechanisms [...]

Externí odkaz: https://doaj.org/article/7c721a61519844518d6cbc693f96643b

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Akademický článek

Self-organized internal architectures of chiral micro-particles

Autor: Clementina Provenzano, Alfredo Mazzulla, Pasquale Pagliusi, Maria P. De Santo, Giovanni Desiderio, Ida Perrotta, Gabriella Cipparrone

Publikováno v: APL Materials, Vol 2, Iss 2, Pp 022103-022103-7 (2014)

The internal architecture of polymeric self-assembled chiral micro-particles is studied by exploring the effect of the chirality, of the particle sizes, and of the interface/surface properties in the ordering of the helicoidal planes. The experimenta

Externí odkaz: https://doaj.org/article/f0c14a096bef4df885caa4b5287b897e

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