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Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome
Autor:
Kasper Thorsen, Vibeke S. Dam, Kasper Kjaer-Sorensen, Lisbeth N. Pedersen, V. Arvydas Skeberdis, Jonas Jurevičius, Rimantas Treinys, Ida M. B. S. Petersen, Morten S. Nielsen, Claus Oxvig, J. Preben Morth, Vladimir V. Matchkov, Christian Aalkjær, Henning Bundgaard, Henrik K. Jensen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Mutations in potassium and calcium channel genes have been associated with cardiac arrhythmias. Here, Jensen et al. show that an anion transporter chloride-bicarbonate exchanger AE3 is also responsible for the genetically-induced mechanism of cardiac
Externí odkaz:
https://doaj.org/article/97e6cbf2131e4127b04d04f0aede118d
Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome
Autor:
Jonas Jurevičius, Morten Schak Nielsen, Claus Oxvig, J. Preben Morth, Vibeke Secher Dam, Kasper Thorsen, Henrik Jensen, Ida M. B. S. Petersen, Lisbeth Nørum Pedersen, V. Arvydas Skeberdis, Henning Bundgaard, Kasper Kjaer-Sorensen, Vladimir V. Matchkov, Christian Aalkjaer, Rimantas Treinys
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Thorsen, K, Dam, V S, Kjaer-Sorensen, K, Pedersen, L N, Skeberdis, V A, Jurevičius, J, Treinys, R, Petersen, I M B S, Nielsen, M S, Oxvig, C, Morth, J P, Matchkov, V V, Aalkjær, C, Bundgaard, H & Jensen, H K 2017, ' Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome ', Nature Communications, vol. 8, no. 1, 1696 . https://doi.org/10.1038/s41467-017-01630-0
Nature Communications
Thorsen, K, Dam, V S, Kjaer-Sorensen, K, Pedersen, L N, Skeberdis, V A, Jurevicius, J, Treinys, R, Petersen, I M B S, Nielsen, M S, Oxvig, C, Morth, J P, Matchkov, V V, Aalkjaer, C, Bundgaard, H & Jensen, H K 2017, ' Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome ', Nature Communications, vol. 8, 1696 . https://doi.org/10.1038/s41467-017-01630-0
Thorsen, K, Dam, V S, Kjaer-Sorensen, K, Pedersen, L N, Skeberdis, V A, Jurevičius, J, Treinys, R, Petersen, I M B S, Nielsen, M S, Oxvig, C, Morth, J P, Matchkov, V V, Aalkjær, C, Bundgaard, H & Jensen, H K 2017, ' Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome ', Nature Communications, vol. 8, no. 1, 1696 . https://doi.org/10.1038/s41467-017-01630-0
Nature Communications
Thorsen, K, Dam, V S, Kjaer-Sorensen, K, Pedersen, L N, Skeberdis, V A, Jurevicius, J, Treinys, R, Petersen, I M B S, Nielsen, M S, Oxvig, C, Morth, J P, Matchkov, V V, Aalkjaer, C, Bundgaard, H & Jensen, H K 2017, ' Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome ', Nature Communications, vol. 8, 1696 . https://doi.org/10.1038/s41467-017-01630-0
Patients with short QT syndrome (SQTS) may present with syncope, ventricular fibrillation or sudden cardiac death. Six SQTS susceptibility genes, encoding cation channels, explain
Mutations in potassium and calcium channel genes have been associ
Mutations in potassium and calcium channel genes have been associ