The p21‐activated kinase 2 (PAK2), but not PAK1, regulates contraction‐stimulated skeletal muscle glucose transport

Autor: Lisbeth L. V. Møller, Ida L. Nielsen, Jonas R. Knudsen, Nicoline R. Andersen, Thomas E. Jensen, Lykke Sylow, Erik A. Richter

Publikováno v: Physiological Reports, Vol 8, Iss 12, Pp n/a-n/a (2020)

Abstract Aim Muscle contraction stimulates skeletal muscle glucose transport. Since it occurs independently of insulin, it is an important alternative pathway to increase glucose transport in insulin‐resistant states, but the intracellular signalin

Externí odkaz: https://doaj.org/article/696e4e5987b24d4a81beb27350263efa

The p21-activated kinase 2 (PAK2), but not PAK1, regulates contraction-stimulated skeletal muscle glucose transport

Autor: Thomas E. Jensen, Erik A. Richter, Nicoline R. Andersen, Ida L. Nielsen, Lykke Sylow, Lisbeth L. V. Møller, Jonas R. Knudsen

Publikováno v: Møller, L L V, Nielsen, I L, Knudsen, J R, Andersen, N R, Jensen, T E, Sylow, L & Richter, E A 2020, ' The p21-activated kinase 2 (PAK2), but not PAK1, regulates contraction-stimulated skeletal muscle glucose transport ', Physiological Reports, vol. 8, no. 12, e14460 . https://doi.org/10.14814/phy2.14460
Physiological Reports, Vol 8, Iss 12, Pp n/a-n/a (2020)
Physiological Reports

Aim Muscle contraction stimulates skeletal muscle glucose transport. Since it occurs independently of insulin, it is an important alternative pathway to increase glucose transport in insulin‐resistant states, but the intracellular signaling mechani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259c594eb80aae9df17c8333f7f5355f
https://curis.ku.dk/ws/files/251694542/M_ller_et_al_Physiological_Reports_2020_Vol_8_12_e14460.pdf

Rac1 governs exercise-stimulated glucose uptake in skeletal muscle through regulation of GLUT4 translocation in mice

Autor: Lykke, Sylow, Ida L, Nielsen, Maximilian, Kleinert, Lisbeth L V, Møller, Thorkil, Ploug, Peter, Schjerling, Philip J, Bilan, Amira, Klip, Thomas E, Jensen, Erik A, Richter

Publikováno v: The Journal of physiology. 594(17)

Exercise increases skeletal muscle energy turnover and one of the important substrates for the working muscle is glucose taken up from the blood. The GTPase Rac1 can be activated by muscle contraction and has been found to be necessary for insulin-st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0ac199cd8e20924f9a620e6316a50396
https://pubmed.ncbi.nlm.nih.gov/27976403