Adipose stem cells are sexually dimorphic cells with dual roles as preadipocytes and resident fibroblasts

Autor: Martin Uhrbom, Lars Muhl, Guillem Genové, Jianping Liu, Henrik Palmgren, Ida Alexandersson, Fredrik Karlsson, Alex-Xianghua Zhou, Sandra Lunnerdal, Sonja Gustafsson, Byambajav Buyandelger, Kasparas Petkevicius, Ingela Ahlstedt, Daniel Karlsson, Leif Aasehaug, Liqun He, Marie Jeansson, Christer Betsholtz, Xiao-Rong Peng

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

Abstract Cell identities are defined by intrinsic transcriptional networks and spatio-temporal environmental factors. Here, we explored multiple factors that contribute to the identity of adipose stem cells, including anatomic location, microvascular

Externí odkaz: https://doaj.org/article/1b79a0f896454151b3ae472ae9fc9feb

PPARγ and PPARα synergize to induce robust browning of white fat in vivo

Autor: Tobias Kroon, Matthew Harms, Stefanie Maurer, Laurianne Bonnet, Ida Alexandersson, Anna Lindblom, Andrea Ahnmark, Daniel Nilsson, Peter Gennemark, Gavin O'Mahony, Victoria Osinski, Coleen McNamara, Jeremie Boucher

Publikováno v: Molecular Metabolism, Vol 36, Iss , Pp - (2020)

Objective: Peroxisome proliferator-activated receptors (PPARs) are key transcription factors that regulate adipose development and function, and the conversion of white into brown-like adipocytes. Here we investigated whether PPARα and PPARγ activa

Externí odkaz: https://doaj.org/article/c8f7d5b18d4a454e9d17350c34792a8f

Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce

Autor: Ida Alexandersson, Nahida Arifen, Firoozeh Salehzadeh, Anders Thorell, Carolina E. Hagberg, Jeremie Boucher, Kirsty L. Spalding, Qian Li, Ping Chen, Niels Krämer, Matthew J. Harms, Carole Knibbe, Shuai Lang, Helena Silva Cascales, Eleni Terezaki, Mervi T. Hyvönen, Myriam Aouadi, Maria Kutschke

Publikováno v: Nature Medicine
Nature Medicine, 2021, 27 (11), pp.1941-1953. ⟨10.1038/s41591-021-01501-8⟩
Nature Medicine, Nature Publishing Group, 2021, 27 (11), pp.1941-1953. ⟨10.1038/s41591-021-01501-8⟩

International audience; Obesity is considered an important factor for many chronic diseases, including diabetes, cardiovascular disease and cancer. The expansion of adipose tissue in obesity is due to an increase in both adipocyte progenitor differen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c988f76cf18afe80c100c7135c054e
https://doi.org/10.1038/s41591-021-01501-8

The transcription factor Foxp1 regulates aerobic glycolysis in adipocytes and myocytes

Autor: Haixia Ma, Valentina Sukonina, Wei Zhang, Fang Meng, Santhilal Subhash, Henrik Palmgren, Ida Alexandersson, Huiming Han, Shuping Zhou, Stefano Bartesaghi, Chandrasekhar Kanduri, Sven Enerbäck

Publikováno v: Journal of Biological Chemistry. :104795

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af4211128cdb8bcb24d5b49f4277bd0a
https://doi.org/10.1016/j.jbc.2023.104795

Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce

Autor: Qian, Li, Carolina E, Hagberg, Helena, Silva Cascales, Shuai, Lang, Mervi T, Hyvönen, Firoozeh, Salehzadeh, Ping, Chen, Ida, Alexandersson, Eleni, Terezaki, Matthew J, Harms, Maria, Kutschke, Nahida, Arifen, Niels, Krämer, Myriam, Aouadi, Carole, Knibbe, Jeremie, Boucher, Anders, Thorell, Kirsty L, Spalding

Publikováno v: Nature medicine. 27(11)

Obesity is considered an important factor for many chronic diseases, including diabetes, cardiovascular disease and cancer. The expansion of adipose tissue in obesity is due to an increase in both adipocyte progenitor differentiation and mature adipo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::719fa533dd18963cc50171abb7ae7d49
https://pubmed.ncbi.nlm.nih.gov/34675377