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Efficacy and Safety of Iclaprim for the Treatment of Skin Structures and Soft Tissue Infections: A Methodological Framework

Autor: Lian Wang, Jin Fan, Linli Zheng, Lingmin Chen

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Background: Skin and soft tissue infections (SSTIs) are among the most common infections worldwide. They manifest in a variety of forms, such as erysipelas, cellulitis, and necrotizing fasciitis. Antibiotics are the significant method for clinical tr

Externí odkaz: https://doaj.org/article/d4ab3a870fb24d898a61424c4a32e2f2

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In vitro activity of iclaprim and comparator agents against Listeria monocytogenes clinical isolates from 2012 to 2018

Autor: David B. Huang, Leonard R. Duncan, Yahse K. Edah, Paul R. Rhomberg, Robert K. Flamm, Michael D. Huband

Publikováno v: Journal of Global Antimicrobial Resistance, Vol 25, Iss , Pp 14-17 (2021)

Objectives: This study examined the in vitro activity of iclaprim and comparators against 40 Listeria monocytogenes clinical isolates mostly (95%) from patients with bloodstream infection (BSI) from the USA, Australia/New Zealand, Latin America and E

Externí odkaz: https://doaj.org/article/35ba935f16e04570a03426ec828258a0

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Comparative efficacy of delafloxacin for complicated and acute bacterial skin and skin structure infections: results from a network meta-analysis

Autor: Edel Falla, Matteo Vacchelli, Ioanna Vlachaki, Dilip Nathwani, Daniela Zinzi, Theo Mantopoulos, Yilin Jiang

Publikováno v: BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-12 (2021)
BMC Infectious Diseases

Background Delafloxacin is a novel fluoroquinolone with broad antibacterial activity against pathogens causing acute bacterial skin and skin structure infections (ABSSSI). This network meta-analysis (NMA) was conducted to evaluate the relative effica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::233a7fff1b5be6c3c08bde5b5c4cbac1
https://doaj.org/article/7d1687cf27834b4abc10838eedd69626

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In vitro activity of iclaprim and comparator agents against Listeria monocytogenes clinical isolates from 2012 to 2018

Autor: Michael D. Huband, Leonard R. Duncan, Robert K. Flamm, Paul R. Rhomberg, David B. Huang, Yahse K. Edah

Publikováno v: Journal of Global Antimicrobial Resistance, Vol 25, Iss, Pp 14-17 (2021)

Objective This study examined the in vitro activity of iclaprim and comparators against 40 Listeria monocytogenes clinical isolates mostly (95%) from patients with bloodstream infections (BSI) from the United States, Australia/New Zealand, Latin Amer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b32e2535607334f93a9c9fad5d938278
https://doi.org/10.1016/j.jgar.2021.02.015

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A novel and practical synthesis of Iclaprim

Autor: Weicheng Zhou, Jing Pan, Ting Zhou, Liang Chen, Kuaile Lin, Liu Weiyuan

Publikováno v: Synthetic Communications. 51:410-418

A novel and facile synthesis of Iclaprim was reported. Started from trimethoprim (TMP), the amino-protection and Friedel–Crafts acetylation with acetic anhydride were simultaneously completed in CH2Cl2 with SnCl4 as catalyst. The Knoevenagel conden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d090cb0eda1aad3f9e7984d68dac8d9
https://doi.org/10.1080/00397911.2020.1831023

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A pooled analysis of patients with wound infections in the Phase 3 REVIVE trials: randomized, double-blind studies to evaluate the safety and efficacy of iclaprim versus vancomycin for treatment of acute bacterial skin and skin structure infections

Autor: Thomas P. Lodise, Thomas L. Holland, G. Ralph Corey, Barbara Balser, William O'Riordan, Antoni Torres, David B. Huang, Stephanie Noviello, Matthew Dryden, Thomas M. File, Amy Scaramucci, Mark H. Wilcox

Publikováno v: Journal of Medical Microbiology. 69:625-630

Introduction. Iclaprim is a diaminopyrimidine antibiotic for the treatment of acute bacterial skin and skin structure infections (ABSSSI) due to Gram-positive pathogens. Aim. This analysis evaluates patients with wound infections from two Phase 3 tri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98740b07be686b0a32ecdcfc6a1be60f
https://doi.org/10.1099/jmm.0.001177

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Role of new antibiotics in the treatment of acute bacterial skin and skin-structure infections

Autor: Filippo Del Puente, Matteo Bassetti, Daniele Roberto Giacobbe, Laura Magnasco

Publikováno v: Current Opinion in Infectious Diseases. 33:110-120

Purpose of review To summarize the available efficacy and safety data of novel agents for treating acute bacterial skin and skin-structure infections (ABSSSI), focusing on those active against methicillin-resistant Staphylococcus aureus (MRSA). Recen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9e1d6a64df05653e50b10f56cad692d
https://doi.org/10.1097/qco.0000000000000631

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