Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Ichiro Takada"'
Autor:
Sayuri Takahashi, Ichiro Takada, Kenichi Hashimoto, Atsushi Yokoyama, Tohru Nakagawa, Makoto Makishima, Haruki Kume
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Molecular targeted therapy using poly (ADP-ribose) polymerase inhibitors has improved survival in patients with castration-resistant prostate cancer (CRPC). However, this approach is only effective in patients with specific genetic mutations
Externí odkaz:
https://doaj.org/article/42d3466dc5294d4fa00de1c0b2ab069a
Autor:
Sayuri Takahashi, Ichiro Takada
Publikováno v:
Asian Journal of Andrology, Vol 25, Iss 2, Pp 158-165 (2023)
Prostate cancer is one of the most common diseases in men worldwide. Surgery, radiation therapy, and hormonal therapy are effective treatments for early-stage prostate cancer. However, the development of castration-resistant prostate cancer has incre
Externí odkaz:
https://doaj.org/article/2b7e6afe2af6475d949514f4e25134fc
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 7, p 1898 (2018)
Farnesoid X receptor (FXR) is a receptor for bile acids and plays an important role in the regulation of bile acid metabolism in the liver. Although FXR has been shown to affect hepatocarcinogenesis through both direct and indirect mechanisms, potent
Externí odkaz:
https://doaj.org/article/9fc52bdbe8c144c8adbd4f80da35e408
Publikováno v:
Journal of Pharmacological Sciences, Vol 97, Iss 2, Pp 184-189 (2005)
Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-dependent nuclear receptor and regulates adipogenesis and fat metabolism. PPARγ is activated by fatty acid derivatives and some synthetic compounds such as the thiazolidinediones.
Externí odkaz:
https://doaj.org/article/416bae1593704679b79140d6af13ac35
Autor:
Ichiro Takada, Mime Kobayashi
Publikováno v:
PPAR Research, Vol 2013 (2013)
While an understanding of lipid metabolism in chickens is critical for a further improvement of food production, there are few studies concerning differences in lipid metabolism mechanisms between chickens and other species at a molecular level. Chic
Externí odkaz:
https://doaj.org/article/026463712065425ea8ae62013401f556
Publikováno v:
PPAR Research, Vol 2012 (2012)
Recent studies have revealed that PPARγ’s transactivation function is regulated by extracellular signals. In particular, cytokines and Wnt family proteins suppress the ligand-inducible transactivation function of PPARγ and attenuate adipogenesis/
Externí odkaz:
https://doaj.org/article/67bae86a4d0340eca7c1e5ae132dcac1
Publikováno v:
PPAR Research, Vol 2010 (2010)
Peroxisome proliferator-activated receptor-gamma (PPAR-γ) is a member of the nuclear receptor (NR) superfamily of ligand-activated transcriptional factors. Among other functions, PPAR-γ acts as a key regulator of the adipogenesis. Since several cyt
Externí odkaz:
https://doaj.org/article/33214d0330714afdb0ce292eb206fe8a
Autor:
Ichiro Takada, Makoto Makishima
Publikováno v:
Expert Opinion on Therapeutic Patents. 30:1-13
Introduction: Peroxisome proliferator-activated receptors (PPARs), PPARα, PPARδ, and PPARγ, play an important role in the regulation of various physiological processes, specifically lipid and energy metabolism and immunity. PPARα agonists (fibrat
Autor:
Ichiro, Takada, Shinya, Hidano, Sayuri, Takahashi, Kaori, Yanaka, Hidesato, Ogawa, Megumi, Tsuchiya, Atsushi, Yokoyama, Shingo, Sato, Hiroki, Ochi, Tohru, Nakagawa, Takashi, Kobayashi, Shinichi, Nakagawa, Makoto, Makishima
Publikováno v:
The Journal of biological chemistry. 298(9)
Ess2, also known as Dgcr14, is a transcriptional co-regulator of CD4
Autor:
Takehiko Kamijo, Tsugumichi Koshinaga, Miki Ohira, Ichiro Takada, Hiroki Nagase, Makoto Makishima, Yusuke Suenaga, Shinichi Kobayashi, Kiyohiro Ando, Satoshi Wada, Verna Cázares-Ordoñez
Publikováno v:
Cancer science. 113(2)
Checkpoint kinase 1 (CHK1) plays a key role in genome surveillance and integrity throughout the cell cycle. Selective inhibitors of CHK1 (CHK1i) are undergoing clinical evaluation for various human malignancies, including neuroblastoma. In this study