Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Ichiro Itonaga"'
Autor:
Yuta Kubota, Yuta Tsubouchi, Masaya Anan, Masanori Kawano, Tatsuya Iwasaki, Ichiro Itonaga, Shinichi Ikeda, Masashi Kataoka, Hiroshi Tsumura, Nobuhiro Kaku, Kazuhiro Tanaka
Publikováno v:
BMC Musculoskeletal Disorders, Vol 25, Iss 1, Pp 1-8 (2024)
Abstract Background Malignant femoral soft tissue tumors are occasionally resected together with the femoral nerves, but this can cause loss of knee extensor muscle activity. To the best of our knowledge, no previous reports have detailed the gait an
Externí odkaz:
https://doaj.org/article/890da963f15b4882b71b0619d0116a6e
Autor:
Masanori Kawano, Kazuhiro Tanaka, Ichiro Itonaga, Tatsuya Iwasaki, Yuta Kubota, Hiroshi Tsumura
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract We elucidated the mechanism through which the reduced expression of miR-152 leads to the overexpression of its target cyclin-dependent kinase-5 activator 1 (CDK5R1) in Ewing’s sarcoma (ES) cells and the role of this mechanism in the prolif
Externí odkaz:
https://doaj.org/article/bd9cd2f423fc45f7b830464abfabab40
Autor:
Yuta Kubota, Kazuhiro Tanaka, Masanori Kawano, Tatsuya Iwasaki, Ichiro Itonaga, Hiroshi Tsumura
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Treatment of malignant tumors, such as rhabdomyosarcoma (RMS), can improve overall survival (OS). It is time-consuming and expensive for patients to obtain benefits from randomized controlled trials (RCTs) with OS as the primary end-point. T
Externí odkaz:
https://doaj.org/article/e16c65f1ffe541719fac5f0e960d1578
Autor:
Masanori Kawano, Tatsuya Iwasaki, Ichiro Itonaga, Yuta Kubota, Kazuhiro Tanaka, Hiroshi Tsumura
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Interaction with surrounding healthy cells plays a major role in the growth and metastasis of osteosarcoma. In this study, we hypothesized that humoral factors, which do not require direct contact with cells, are involved in the interaction
Externí odkaz:
https://doaj.org/article/3a0e95e64d914151a2b33d5237d3e5f7
Autor:
Yuta Kubota, Kazuhiro Tanaka, Masanori Hisaoka, Tsutomu Daa, Tatsuya Iwasaki, Masanori Kawano, Ichiro Itonaga, Hiroshi Tsumura
Publikováno v:
BMC Musculoskeletal Disorders, Vol 22, Iss 1, Pp 1-9 (2021)
Abstract Background It is very rare for clear cell sarcomas (CCS) to arise in the bone. During diagnosis, it is important to distinguish primary CCS of bone from bone metastasis of melanoma because this difference fundamentally changes the therapeuti
Externí odkaz:
https://doaj.org/article/659d07d75ea94fefa924cd26f8c37db9
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-9 (2020)
Abstract Background In randomized controlled trials (RCTs) of adjuvant treatment for malignant tumors, event-free survival (EFS) is considered the most acceptable surrogate for overall survival (OS). However, even though EFS has repeatedly been selec
Externí odkaz:
https://doaj.org/article/6cf3a8d588164c95bf49792f49e06c78
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-9 (2019)
Abstract Background Overall survival is the true endpoint for most randomized controlled trials (RCTs) of malignant tumors, whereas progression-free survival (PFS) is considered the most reliable surrogate endpoint for overall survival (OS). The pres
Externí odkaz:
https://doaj.org/article/2fab6b22cdb4452bbeeb3203c1db2901
Publikováno v:
Cell Communication and Signaling, Vol 16, Iss 1, Pp 1-11 (2018)
Abstract Background Osteosarcoma (OS) is the representative primary malignant bone tumor with the highest incidence. It is known that malignant phenotypes of OS, such as proliferation, invasion, and metastasis, are significantly influenced not only b
Externí odkaz:
https://doaj.org/article/29c0025787c347a3956fa2e2375aad3f
Publikováno v:
Cancer Cell International, Vol 18, Iss 1, Pp 1-11 (2018)
Abstract Background MicroRNAs (miRNAs) are endogenous, small non-coding RNAs that play important roles in multiple biological processes. Here, we show that miRNAs play an important function in the down-regulation of FAS expression in Ewing’s sarcom
Externí odkaz:
https://doaj.org/article/a3dcafdc43aa41669e980f6606e55372
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0210671 (2019)
ObjectiveThe standard treatment for patients with advanced/metastatic soft tissue sarcomas (ASTS) is systemic chemotherapy with doxorubicin. A previous meta-analysis of 8 randomized controlled trials (RCTs) demonstrated the superiority of single-agen
Externí odkaz:
https://doaj.org/article/c63234433733418f8719b3c7d8051503