Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Ichiro Ikegaki"'
Autor:
Shin-ichi Satoh, Masakazu Takayasu, Koh Kawasaki, Ichiro Ikegaki, Asako Hitomi, Kazuo Yano, Masato Shibuya, Toshio Asano
Publikováno v:
Journal of Pharmacological Sciences, Vol 118, Iss 1, Pp 92-98 (2012)
We investigated the anti-vasospastic potential of fasudil’s active metabolite, hydroxyfasudil, a Rho-kinase inhibitor, after subarachnoid hemorrhage (SAH) and also its effect on hemorheological abnormalities following cerebral ischemia. Chronic cer
Externí odkaz:
https://doaj.org/article/0bd4705d70864104aaa00d673e47e588
Autor:
Hiroshi Kuriyama, Emika Sugimoto, Yukihiro Isogai, Toshinori Ishizuya, Aya Takakura, Ryoko Takao-Kawabata, Ichiro Ikegaki, Osamu Nakazono
Publikováno v:
Calcified Tissue International
Intermittent repeated administration of teriparatide (TPTD) has potent anabolic effects on bones in vivo. However, TPTD has both anabolic and catabolic effects on osteoblasts in vitro, and the mechanisms underlying its promotion of bone formation are
Autor:
Ichiro Ikegaki, Aya Takakura, Ryoko Takao-Kawabata, Toshinori Ishizuya, Shinya Tanaka, Osamu Nakazono, Hiromi Oda, Yukari Shimazu, Emika Sugimoto, Yukihiro Isogai, Hiroshi Kuriyama
Publikováno v:
Calcified Tissue International
Daily and weekly administration of teriparatide (PTH1–34) reduces the risk of osteoporotic bone fractures. However, their effects on markers of bone formation and bone resorption differ. These results indicate that the dosing frequency of teriparat
Autor:
Ryo-ich, Takei 1, Ichiro, Ikegaki 1, *, Katsushi, Shibata 2, Gozoh, Tsujimoto 2, Toshio, Asano 1
Publikováno v:
In Japanese Journal of Pharmacology 1999 79(4):447-454
Publikováno v:
European Journal of Pharmacology. 700:194-200
Naftopidil is an α(1D) and α(1A) subtype-selective α(1)-adrenoceptor antagonist that has been used to treat lower urinary tract symptoms of benign prostatic hyperplasia. In this study, we investigated the effects of naftopidil on 5-hydroxytryptami
Autor:
Ichiro Ikegaki, Koh Kawasaki, Masakazu Takayasu, Toshio Asano, Masato Shibuya, Kazuo Yano, Asako Hitomi, Shin'ichi Satoh
Publikováno v:
Journal of Pharmacological Sciences, Vol 118, Iss 1, Pp 92-98 (2012)
We investigated the anti-vasospastic potential of fasudil’s active metabolite, hydroxyfasudil, a Rho-kinase inhibitor, after subarachnoid hemorrhage (SAH) and also its effect on hemorheological abnormalities following cerebral ischemia. Chronic cer
Autor:
Osamu Nakazono, Koh Kawasaki, Asako Hitomi, Mitsunobu Mohri, Ichiro Ikegaki, Masakazu Iwasaki, Toshio Asano, Shin'ichi Satoh
Publikováno v:
Brain Research Bulletin. 81:191-195
We investigated the neuroprotective effects of fasudil's active metabolite, hydroxyfasudil, a Rho-kinase inhibitor, in a rat stroke model in which endothelial damage and subsequent thrombotic occlusion were selectively induced in perforating arteries
Autor:
Kazuo Yano, Koh Kawasaki, Yuji Ohtsuka, Shunsuke Tawara, Hiroshi Kuriyama, Yuki Yoshino, Toshio Asano, Kunie Sasaki, Minoru Seto, Shin'ichi Satoh, Ichiro Ikegaki
Publikováno v:
Journal of Molecular Neuroscience. 39:59-68
Whether Rho-kinase activity is really associated with the pathogenesis of cerebral infarction remains unclear. To consider this question, we investigated correspondences between severity of neurological deficit, infarct size, amount of various marker
Publikováno v:
Biochemical and Biophysical Research Communications. 424:338-340
Using a cellular approach, the present study examined whether fasudil and active metabolite hydroxyfasudil, Rho-kinase inhibitors, exert a direct protective effect on endothelin-induced cardiac myocyte hypertrophy in vitro. Treatment with endothelin
Autor:
Tamami Yamaguchi, Ichiro Ikegaki, Kazumi Shiraiwa, Hiroaki Shimokawa, Asako Hitomi, T. Asano, S. Satoh, Norihiro Sato
Publikováno v:
European Journal of Pharmacology. 455:169-174
This study was designed to investigate possible effects of the Rho-kinase inhibitor, fasudil, on the progression of renal failure in rats with unilateral ureteral obstruction. The renal failure markers monitored were the extent of renal interstitial