Zobrazeno 1 - 10
of 821
pro vyhledávání: '"Ichiro, Nishimura"'
Autor:
Brendan Y. Shi, Varun Sriram, Shannon Y. Wu, Dave Huang, Alexis Cheney, Melodie F. Metzger, Oskar Sundberg, Karen M. Lyons, Charles E. McKenna, Ichiro Nishimura, Thomas J. Kremen
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Background: Osteoadsorptive fluorogenic sentinel 3 (OFS-3) is a recently described compound that contains a bone-targeting bisphosphonate (BP) and cathepsin K (Ctsk)-triggered fluorescence signal. A prior study in a murine Achilles repair model demon
Externí odkaz:
https://doaj.org/article/a4ab903c667d429f834a03dd11eeb2a1
Autor:
Ken Murakami, Daiki Kambe, Yasuhiro Yokoi, Hajime Wakui, Shun Hayakawa, Nozomi Hirane, Ryosuke Koide, Michiru Otaki, Noriko Nagahori, Shin-Ichiro Nishimura
Publikováno v:
Advanced NanoBiomed Research, Vol 3, Iss 12, Pp n/a-n/a (2023)
Human neuraminidase‐1 (NEU1) plays a much more profound function in human cancers than previously considered. It is demonstrated that cancer cell surface NEU1 is a desired gatekeeper for an innovative anticancer therapeutic nanomedicine enabling ac
Externí odkaz:
https://doaj.org/article/3bc271e0d4c848948146342b54489a5a
Publikováno v:
eLife, Vol 12 (2023)
Periodontitis, one of the most common non-communicable diseases, is characterized by chronic oral inflammation and uncontrolled tooth supporting alveolar bone resorption. Its underlying mechanism to initiate aberrant oral barrier immunity has yet to
Externí odkaz:
https://doaj.org/article/1f228c86f89345e69424ba8f03757fb7
Autor:
Lareno L. Villones, Anna-Kristin Ludwig, Hiroyuki Kumeta, Seiya Kikuchi, Rika Ochi, Tomoyasu Aizawa, Shin-Ichiro Nishimura, Hans-Joachim Gabius, Hiroshi Hinou
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Dystroglycan (DG), which constitutes a part of the dystrophin–glycoprotein complex, connects the extracellular matrix to the cytoskeleton. The matriglycans presented by the extracellular α-DG serve as a contact point with extracellular ma
Externí odkaz:
https://doaj.org/article/3b313ae12f4c4ebbae078d91bb584ce4
Autor:
Michiru Otaki, Nozomi Hirane, Yayoi Natsume-Kitatani, Mari Nogami Itoh, Masanori Shindo, Yoichi Kurebayashi, Shin-Ichiro Nishimura
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract This study presents “mouse tissue glycome atlas” representing the profiles of major N-glycans of mouse glycoproteins that may define their essential functions in the surface glycocalyx of mouse organs/tissues and serum-derived extracellu
Externí odkaz:
https://doaj.org/article/5de9196a41814d5181581bf61c051185
Autor:
Takeru Kondo, Hiroko Okawa, Akishige Hokugo, Bhumika Shokeen, Oskar Sundberg, Yiying Zheng, Charles E. McKenna, Renate Lux, Ichiro Nishimura
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
A highly sensitive imaging probe shows that oral microbial extracellular DNA triggers early activity of Ctsk in gingival fibroblasts, initiating periodontitis in mice.
Externí odkaz:
https://doaj.org/article/300a9ed6cad24791b83f74a67a93b443
Autor:
Hiroko Okawa, Takeru Kondo, Akishige Hokugo, Philip Cherian, Oskar Sundberg, Jesus J. Campagna, Boris A. Kashemirov, Varghese John, Shuting Sun, Frank H. Ebetino, Charles E. McKenna, Ichiro Nishimura
Publikováno v:
Communications Medicine, Vol 2, Iss 1, Pp 1-17 (2022)
Okawa et al. evaluate a fluorescent risedronate analogue, 800CW-pRIS, as a potential treatment for medication-related osteonecrosis of the jaw. The authors demonstrate an improvement in wound healing and inflammation with 800CW-pRIS pre-treatment in
Externí odkaz:
https://doaj.org/article/fa4c14d86d1e48f7abda46536e834eaf
Autor:
Adam Clements, Yoichiro Shibuya, Akishige Hokugo, Zachary Brooks, Yvonne Roca, Takeru Kondo, Ichiro Nishimura, Reza Jarrahy
Publikováno v:
Frontiers in Medicine, Vol 9 (2023)
BackgroundThe core circadian gene Neuronal PAS domain 2 (NPAS2) is expressed in dermal fibroblasts and has been shown to play a critical role in regulating collagen synthesis during wound healing. We have performed high throughput drug screening to i
Externí odkaz:
https://doaj.org/article/2155ea14592f4589934aa6645c14a525
Autor:
Kawaljit Kaur, Yujie Sun, Keiichi Kanayama, Kenzo Morinaga, Akishige Hokugo, Ichiro Nishimura, Anahid Jewett
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionThe potential mechanisms governing drug induced osteonecrosis of the jaw (ONJ) is not well understood, and is one of the objectives of this study. Thus, we tested the release of IFN-γ within different immune compartments including bone m
Externí odkaz:
https://doaj.org/article/0a852aafffd246d69d2a24b08221bb53
Autor:
Weixian Xi, Vishal Hegde, Stephen D. Zoller, Howard Y. Park, Christopher M. Hart, Takeru Kondo, Christopher D. Hamad, Yan Hu, Amanda H. Loftin, Daniel O. Johansen, Zachary Burke, Samuel Clarkson, Chad Ishmael, Kellyn Hori, Zeinab Mamouei, Hiroko Okawa, Ichiro Nishimura, Nicholas M. Bernthal, Tatiana Segura
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Implant infection is the most common mode of joint replacement failure with serious complications. Here, the authors report on the in vivo application of a prophylactic coating technology that can incorporate a range of antibiotics and be applied in
Externí odkaz:
https://doaj.org/article/76aa4dbb4edd442f94aaa3e0f4b4b488