Zobrazeno 1 - 10
of 171
pro vyhledávání: '"Ichiro, Hayakawa"'
Autor:
Haruna Ebisu, Kana Shintani, Takumi Chinen, Yoko Nagumo, Shuya Shioda, Taisei Hatanaka, Akira Sakakura, Ichiro Hayakawa, Hideo Kigoshi, Takeo Usui
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
α/β-Tubulin inhibitors that alter microtubule (MT) dynamics are commonly used in cancer therapy, however, these inhibitors also cause severe side effects such as peripheral neuropathy. γ-Tubulin is a possible target as antitumor drugs with low sid
Externí odkaz:
https://doaj.org/article/538758ef14db4b708215884f46c3aa3d
Autor:
Ichiro Hayakawa, Takeo Usui
Publikováno v:
Journal of Synthetic Organic Chemistry, Japan. 80:563-573
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddd325b54694eabdd6013cac4eac47e6
https://doi.org/10.5059/yukigoseikyokaishi.80.563
https://doi.org/10.5059/yukigoseikyokaishi.80.563
Autor:
Michiko Yamato, Jun Hasegawa, Takanori Maejima, Chiharu Hattori, Kazuyoshi Kumagai, Akiko Watanabe, Yumi Nishiya, Tomoko Shibutani, Tetsuo Aida, Ichiro Hayakawa, Takashi Nakada, Yuki Abe, Toshinori Agatsuma
Publikováno v:
Molecular Cancer Therapeutics. 21:635-646
B7-H3 is overexpressed in various solid tumors and has been considered as an attractive target for cancer therapy. Here, we report the development of DS-7300a, a novel B7-H3–targeting antibody–drug conjugate with a potent DNA topoisomerase I inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3759d969aadf128e10d9488ca610c7
https://doi.org/10.1158/1535-7163.mct-21-0554
https://doi.org/10.1158/1535-7163.mct-21-0554
Autor:
Toshinori Agatsuma, Yuki Abe, Takashi Nakada, Ichiro Hayakawa, Tetsuo Aida, Tomoko Shibutani, Yumi Nishiya, Akiko Watanabe, Kazuyoshi Kumagai, Chiharu Hattori, Takanori Maejima, Jun Hasegawa, Michiko Yamato
Supplementary Data from DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-Based Antibody–Drug Conjugate Targeting B7-H3, Exerts Potent Antitumor Activities in Preclinical Models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2555c866d4671115aaf3d352455d62eb
https://doi.org/10.1158/1535-7163.22521898.v1
https://doi.org/10.1158/1535-7163.22521898.v1
Autor:
Toshinori Agatsuma, Yuki Abe, Takashi Nakada, Ichiro Hayakawa, Tetsuo Aida, Tomoko Shibutani, Yumi Nishiya, Akiko Watanabe, Kazuyoshi Kumagai, Chiharu Hattori, Takanori Maejima, Jun Hasegawa, Michiko Yamato
B7-H3 is overexpressed in various solid tumors and has been considered as an attractive target for cancer therapy. Here, we report the development of DS-7300a, a novel B7-H3–targeting antibody–drug conjugate with a potent DNA topoisomerase I inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a31bd9f9c43f7e981e6be14ca30c4b1
https://doi.org/10.1158/1535-7163.c.6543217
https://doi.org/10.1158/1535-7163.c.6543217
Autor:
Toshinori Agatsuma, Yuki Abe, Ichiro Hayakawa, Takashi Nakada, Ryo Atsumi, Takehiro Hirai, Shingo Arakawa, Masataka Oitate, Hiromi Okamoto, Masako Soma, Naoya Harada, Chiaki Ishii, Junko Yamaguchi, Katsunobu Hagihara, Tetsuo Aida, Yusuke Ogitani
Histopathological findings in the intestines, bone marrow and lung in the repeated dose study in monkeys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e3518d2b57487fa532fd107abd8380
https://doi.org/10.1158/1078-0432.22466577.v1
https://doi.org/10.1158/1078-0432.22466577.v1
Autor:
Toshinori Agatsuma, Suguru Ueno, Masato Murakami, Yuki Abe, Takashi Kagari, Kenichi Wakita, Taisei Nomura, Takashi Nakada, Koji Morita, Ichiro Hayakawa, Tsuyoshi Karibe, Tomomichi Ishizaka, Takuma Iguchi, Yoshinobu Shiose, Naoyuki Maeda, Yuki Kaneda, Manabu Abe, Akiko Zembutsu, Yusuke Ogitani, Kenji Hirotani, Yasuki Kamai, Kumiko Koyama, Yuuri Hashimoto
Growth inhibition activity in 8 cell lines with different HER3 expression levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::880231614c871ee8daf9d171aeb6f711
https://doi.org/10.1158/1078-0432.22471701
https://doi.org/10.1158/1078-0432.22471701
Autor:
Toshinori Agatsuma, Suguru Ueno, Masato Murakami, Yuki Abe, Takashi Kagari, Kenichi Wakita, Taisei Nomura, Takashi Nakada, Koji Morita, Ichiro Hayakawa, Tsuyoshi Karibe, Tomomichi Ishizaka, Takuma Iguchi, Yoshinobu Shiose, Naoyuki Maeda, Yuki Kaneda, Manabu Abe, Akiko Zembutsu, Yusuke Ogitani, Kenji Hirotani, Yasuki Kamai, Kumiko Koyama, Yuuri Hashimoto
Cell surface expression of HER3 and HER2 on human cancer cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d196b076a66226bf5f6c138392bf157
https://doi.org/10.1158/1078-0432.22471704.v1
https://doi.org/10.1158/1078-0432.22471704.v1
Autor:
Toshinori Agatsuma, Suguru Ueno, Masato Murakami, Yuki Abe, Takashi Kagari, Kenichi Wakita, Taisei Nomura, Takashi Nakada, Koji Morita, Ichiro Hayakawa, Tsuyoshi Karibe, Tomomichi Ishizaka, Takuma Iguchi, Yoshinobu Shiose, Naoyuki Maeda, Yuki Kaneda, Manabu Abe, Akiko Zembutsu, Yusuke Ogitani, Kenji Hirotani, Yasuki Kamai, Kumiko Koyama, Yuuri Hashimoto
Purpose:HER3 is a compelling target for cancer treatment; however, no HER3-targeted therapy is currently clinically available. Here, we produced U3-1402, an anti-HER3 antibody–drug conjugate with a topoisomerase I inhibitor exatecan derivative (DXd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d33bfc877155e5b7eac75bca137859
https://doi.org/10.1158/1078-0432.c.6527970.v1
https://doi.org/10.1158/1078-0432.c.6527970.v1
Autor:
Toshinori Agatsuma, Suguru Ueno, Masato Murakami, Yuki Abe, Takashi Kagari, Kenichi Wakita, Taisei Nomura, Takashi Nakada, Koji Morita, Ichiro Hayakawa, Tsuyoshi Karibe, Tomomichi Ishizaka, Takuma Iguchi, Yoshinobu Shiose, Naoyuki Maeda, Yuki Kaneda, Manabu Abe, Akiko Zembutsu, Yusuke Ogitani, Kenji Hirotani, Yasuki Kamai, Kumiko Koyama, Yuuri Hashimoto
Summary of repeated dose toxicity studies in rats and monkeys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31345a27ba184e20db8d45cca77a20fe
https://doi.org/10.1158/1078-0432.22471692.v1
https://doi.org/10.1158/1078-0432.22471692.v1