Zobrazeno 1 - 10
of 3 478
pro vyhledávání: '"Ichio"'
Autor:
Shun Kaneko, Shunsuke Imai, Tomomi Uchikubo-Kamo, Tamao Hisano, Nobuaki Asao, Mikako Shirouzu, Ichio Shimada
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract G-protein-coupled receptors (GPCRs) play pivotal roles in various physiological processes. These receptors are activated to different extents by diverse orthosteric ligands and allosteric modulators. However, the mechanisms underlying these
Externí odkaz:
https://doaj.org/article/8986cdcaf6aa480fa00140791f388d6f
Autor:
Yuki Toyama, Ichio Shimada
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The DEAD-box RNA helicase (DDX) plays a central role in many aspects of RNA metabolism by remodeling the defined structure of RNA molecules. While a number of structural studies have revealed the atomistic details of the interaction between
Externí odkaz:
https://doaj.org/article/ab98ab336db7417f9a8c469bc0024ff2
Autor:
Tadashi Shiohama, Hideki Uchikawa, Nobuhiro Nitta, Tomozumi Takatani, Shingo Matsuda, Alpen Ortug, Emi Takahashi, Daisuke Sawada, Eiji Shimizu, Katsunori Fujii, Ichio Aoki, Hiromichi Hamada
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Hedgehog signaling is a highly conserved pathway that plays pivotal roles in morphogenesis, tumorigenesis, osteogenesis, and wound healing. Previous investigations in patients with Gorlin syndrome found low harm avoidance traits, and increased volume
Externí odkaz:
https://doaj.org/article/3f6094d326054064a78690b38cd63dd2
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract KRAS mutations are major drivers of various cancers. Recently, allele-specific inhibitors of the KRAS G12C mutant were developed that covalently modify the thiol of Cys12, thereby trapping KRAS in an inactive GDP-bound state. To study the me
Externí odkaz:
https://doaj.org/article/0c9551541ea448069a8fe56f72999984
Autor:
Shan Gao, Yutaka Miura, Akira Sumiyoshi, Satoshi Ohno, Keisuke Ogata, Takahiro Nomoto, Makoto Matsui, Yuto Honda, Minoru Suzuki, Megumi Iiyama, Kensuke Osada, Ichio Aoki, Nobuhiro Nishiyama
Publikováno v:
Advanced Science, Vol 11, Iss 7, Pp n/a-n/a (2024)
Abstract Nano‐sized contrast agents (NCAs) hold potential for highly specific tumor contrast enhancement during magnetic resonance imaging. Given the quantity of contrast agents loaded into a single nano‐carrier and the anticipated relaxation eff
Externí odkaz:
https://doaj.org/article/b049c92763fc4672b82bdd990b49ad3d
Autor:
Shang-Wei Li, Ming-Feng Hsieh, Taehun Hong, Pengwen Chen, Kensuke Osada, Xueying Liu, Ichio Aoki, Jiashing Yu, Kevin C.-W. Wu, Horacio Cabral
Publikováno v:
Advanced NanoBiomed Research, Vol 4, Iss 1, Pp n/a-n/a (2024)
Metal–organic frameworks (MOFs), such as the magnetic resonance imaging‐fit MIL‐100 based on Fe, are gaining significant attention as versatile theranostics with high‐loading capability. Moreover, as MOFs can be engineered to target tumors, t
Externí odkaz:
https://doaj.org/article/7533571db0c547cba951b7fae784b6a5
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Many RNA viruses employ internal ribosome entry sites (IRESs) in their genomic RNA to commandeer the host’s translational machinery for replication. The IRES from encephalomyocarditis virus (EMCV) interacts with eukaryotic translation init
Externí odkaz:
https://doaj.org/article/78178287e2944361b00c4f2ec6822014
Autor:
Akira Sumiyoshi, Sayaka Shibata, Dessislava Lazarova, Zhivko Zhelev, Ichio Aoki, Rumiana Bakalova
Publikováno v:
Redox Report, Vol 28, Iss 1 (2023)
ABSTRACTObjectives: The present study describes a pharmacological strategy for the treatment of glioblastoma by redoxcycling ‘mitocans’ such as quinone/ascorbate combination drugs, based on their tumor-selective redox-modulating effects and toler
Externí odkaz:
https://doaj.org/article/4870639b8f2a41248188487048bdc3b6
Autor:
Megumi Ueno, Raj Kumar Parajuli, Hiromu Ito, Megumi Iiyama, Saaya Suzuki, Ken-ichiro Matsumoto, Ikuo Nakanishi, Ichio Aoki, Akira Sumiyoshi
Publikováno v:
Advances in Redox Research, Vol 8, Iss , Pp 100067- (2023)
The effects of X-ray irradiation on the redox status of colorectal tissues were investigated using magnetic resonance redox imaging.The pyrrolidine-ring nitroxyl contrast agent, 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-N-oxyl (CmP), was used as a s
Externí odkaz:
https://doaj.org/article/c91f96c187594713827e5ae9e7fcb325
Autor:
Yutaro Shiraishi, Yutaka Kofuku, Takumi Ueda, Shubhi Pandey, Hemlata Dwivedi-Agnihotri, Arun K. Shukla, Ichio Shimada
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
β-arrestins commonly bind to two distinct elements in GPCRs: the phosphorylated carboxyl terminal tail (C tail) and the cytoplasmic face of the transmembrane region (TM core). Here, the authors use methyl-TROSY NMR measurements to characterise the i
Externí odkaz:
https://doaj.org/article/c2744b4652694e1eb22b0a1f83faea09