Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Ichiji Namatame"'
Integration of a fully automated flow cytometry system with high robustness into a Screening Station
Publikováno v:
SLAS Technology, Vol 29, Iss 6, Pp 100215- (2024)
In recent years, there has been an increasing demand for the detection of rare cells in drug discovery research, such as cells that have differentiated off-purpose or are required for immunogenicity evaluation. Since detection and quantification limi
Externí odkaz:
https://doaj.org/article/3321c3fd36044b37adceb161cd09e25a
Autor:
Ichiji Namatame, Kana Ishii, Takashi Shin, Daisuke Shimojo, Yukiko Yamagishi, Hidemitsu Asano, Yuuki Kishimoto, Hiromitsu Fuse, Yohei Nishi, Hidetoshi Sakurai, Tatsutoshi Nakahata, Haruna Sasaki-Iwaoka
Publikováno v:
SLAS Technology, Vol 28, Iss 5, Pp 351-360 (2023)
Due to their physiological relevance, cell-based assays using human-induced pluripotent stem cell (iPSC)-derived cells are a promising in vitro pharmacological evaluation system for drug candidates. However, cell-based assays involve complex processe
Externí odkaz:
https://doaj.org/article/4ec6426974f04615a35a7e1621a58788
Autor:
Ryunosuke Yoshino, Nobuaki Yasuo, Yohsuke Hagiwara, Takashi Ishida, Daniel Ken Inaoka, Yasushi Amano, Yukihiro Tateishi, Kazuki Ohno, Ichiji Namatame, Tatsuya Niimi, Masaya Orita, Kiyoshi Kita, Yutaka Akiyama, Masakazu Sekijima
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Chagas disease results from infection by Trypanosoma cruzi and is a neglected tropical disease (NTD). Although some treatment drugs are available, their use is associated with severe problems, including adverse effects and limited effectiven
Externí odkaz:
https://doaj.org/article/9864fe2ce67f43499bde2b3251ec52d6
Autor:
Daniel Ken Inaoka, Masakazu Sekijima, Takashi Ishida, Yutaka Akiyama, Masaya Orita, Kiyoshi Kita, Yukihiro Tateishi, Ryunosuke Yoshino, Tatsuya Niimi, Yohsuke Hagiwara, Kazuki Ohno, Ichiji Namatame, Yasushi Amano, Nobuaki Yasuo
Background Chagas disease is caused by the parasite Trypanosoma cruzi and is one of the neglected tropical diseases. Although two types of drugs are currently available, new drugs are still required because they have serious side effects. To develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69cd2fda5448f2fe1c6d1d106de6a02a
https://doi.org/10.26434/chemrxiv-2021-qk2ns
https://doi.org/10.26434/chemrxiv-2021-qk2ns
Autor:
Koji Furukawa, Ichiji Namatame, Osamu Tani, Tomohiko Yamaguchi, Hitoshi Sakashita, Tomomi Kubota, Kazuhiko Yamasaki
Publikováno v:
FEBS Open Bio
Dihydroorotate dehydrogenase (DHODH) is a flavin-binding enzyme essential for pyrimidine biosynthesis, which converts dihydroorotate to orotate. Three-dimensional structures of cytosolic DHODH of parasitic protozoa are of interest in drug discovery f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57dc2378763aad666d1a5d27c8fcdf9a
http://europepmc.org/articles/PMC5881531
http://europepmc.org/articles/PMC5881531
Autor:
Kazuya Honbou, Naoyuki Masuda, Ryushi Seo, Yasushi Amano, Masaki Tomishima, Mayako Yamazaki, Ichiji Namatame, Ayaka Chino, Takuma Mihara, Wataru Hamaguchi
Publikováno v:
Chemical and Pharmaceutical Bulletin. 66:286-294
In this study, we report the identification of potent pyrimidoindazoles as phosphodiesterase10A (PDE10A) inhibitors by using the method of fragment-based drug discovery (FBDD). The pyrazolopyridine derivative 2 was found to be a fragment hit compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24a18a22e367934bba8d6a598acca777
https://doi.org/10.1248/cpb.c17-00836
https://doi.org/10.1248/cpb.c17-00836
Autor:
Yusuke Tomimoto, Sadao Kuromitsu, Costas A. Lyssiotis, Tomohiro Yoshida, Ichiji Namatame, Naofumi Taoka, Toshiko Yahata, Osamu Kaneko, Shingo Yamasaki, Lewis C. Cantley
Publikováno v:
Biochem Biophys Res Commun
Metabolic programs are rewired in cancer cells to support survival and tumor growth. Among these, recent studies have demonstrated that glutamate-oxaloacetate transaminase 1 (GOT1) plays key roles in maintaining redox homeostasis and proliferation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3d386011d0c2a3f8b33515543939c84
https://pubmed.ncbi.nlm.nih.gov/31787239
https://pubmed.ncbi.nlm.nih.gov/31787239
Autor:
Osamu Tani, Tatsuya Niimi, Yukihiro Tateishi, Kazuhiko Yamasaki, Koji Furukawa, Hitoshi Sakashita, Ichiji Namatame, Eiki Tanabe
Publikováno v:
Journal of Medicinal Chemistry. 59:2261-2266
Although NMR in fragment-based drug discovery is utilized almost exclusively to evaluate physical binding between molecules, it should be also a powerful tool for biochemical assay, evaluating inhibitory effect of compounds on enzymatic activity. Tim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e3449217cd1eb69980f2a49742747c
https://doi.org/10.1021/acs.jmedchem.5b01769
https://doi.org/10.1021/acs.jmedchem.5b01769
Autor:
Ichiji Namatame
Publikováno v:
YAKUGAKU ZASSHI. 136:231-236
Neglected tropical diseases (NTDs) are an extremely important issue facing global health care. To improve "access to health" where people are unable to access adequate medical care due to poverty and weak healthcare systems, we have established two c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ec24a376899d5c90cdd4bba683ed9c5
https://doi.org/10.1248/yakushi.15-00233-4
https://doi.org/10.1248/yakushi.15-00233-4
Autor:
Shusaku Mizukami, Osamu Tani, Yukihiro Tateishi, Kazuhiko Yamasaki, Takayuki Suzuki, Tatsuya Niimi, Yukie Akutsu, Tetsuo Yanagi, Tomomi Kubota, Shinji Ito, Ichiji Namatame, Tomohiko Yamaguchi, Yasunori Chiba, Koji Furukawa, Kenji Hirayama, Hitoshi Sakashita
Publikováno v:
Journal of medicinal chemistry. 61(11)
Oxidosqualene cyclase (OSC), a membrane-associated protein, is a key enzyme of sterol biosynthesis. Here we report a novel assay for OSC, involving reaction in aqueous solution, NMR quantification in organic solvent, and factor analysis of spectra. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5f661d8d78fdd624c805f90da8058bf
https://pubmed.ncbi.nlm.nih.gov/30004699
https://pubmed.ncbi.nlm.nih.gov/30004699