Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Icaro A. Simon"'
Autor:
Christian B M, Poulie, Eline, Pottie, Icaro A, Simon, Kasper, Harpsøe, Laura, D'Andrea, Igor V, Komarov, David E, Gloriam, Anders A, Jensen, Christophe P, Stove, Jesper L, Kristensen
Publikováno v:
Journal of medicinal chemistry. 65(18)
The serotonin 2A receptor (5-HT
Autor:
Sijie Huang, Peiyu Xu, Dan-Dan Shen, Icaro A. Simon, Chunyou Mao, Yangxia Tan, Huibing Zhang, Kasper Harpsøe, Huadong Li, Yumu Zhang, Chongzhao You, Xuekui Yu, Yi Jiang, Yan Zhang, David E. Gloriam, H. Eric Xu
Publikováno v:
Huang, S, Xu, P, Shen, D D, Simon, I A, Mao, C, Tan, Y, Zhang, H, Harpsøe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D E & Xu, H E 2022, ' GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors ', Molecular cell, vol. 82, no. 14, pp. 2681-2695.e6 . https://doi.org/10.1016/j.molcel.2022.05.031
Molecular cell, 82(14), 2681-2695.e6. Cell Press
Molecular cell, 82(14), 2681-2695.e6. Cell Press
Serotonin (or 5-hydroxytryptamine, 5-HT) is an important neurotransmitter that activates 12 different G protein-coupled receptors (GPCRs) through selective coupling of Gs, Gi, or Gq proteins. The structural basis for G protein subtype selectivity by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c14e6f3505ee05c519a1463efa9c29
https://hdl.handle.net/1871.1/713d857a-269d-42a6-a385-466fed3a7d58
https://hdl.handle.net/1871.1/713d857a-269d-42a6-a385-466fed3a7d58
Autor:
Laura D'Andrea, Anders Asbjørn Jensen, Jesper Kristensen, Igor Komarov, Christophe Stove, Kasper Harpsøe, David Gloriam, Icaro Ariel Simon, Eline Pottie, Christian Poulie
Publikováno v:
JOURNAL OF MEDICINAL CHEMISTRY
Poulie, C B M, Pottie, E, Simon, I A, Harpsøe, K, D’andrea, L, Komarov, I V, Gloriam, D E, Jensen, A A, Stove, C P & Kristensen, J L 2022, ' Discovery of β-Arrestin-Biased 25CN-NBOH-Derived 5-HT 2A Receptor Agonists ', Journal of Medicinal Chemistry, vol. 65, no. 18, pp. 12031–12043 . https://doi.org/10.1021/acs.jmedchem.2c00702
Poulie, C B M, Pottie, E, Simon, I A, Harpsøe, K, D’andrea, L, Komarov, I V, Gloriam, D E, Jensen, A A, Stove, C P & Kristensen, J L 2022, ' Discovery of β-Arrestin-Biased 25CN-NBOH-Derived 5-HT 2A Receptor Agonists ', Journal of Medicinal Chemistry, vol. 65, no. 18, pp. 12031–12043 . https://doi.org/10.1021/acs.jmedchem.2c00702
The serotonin 2A receptor (5-HT2AR) is the mediator of the psychedelic effects of serotonergic psychedelics, which have shown promising results in clinical studies for several neuropsychiatric indications. The 5-HT2AR is able to signal through the G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab01693a28151d7faffb813f0dca56de
https://hdl.handle.net/1854/LU-01GS866C80CYSP9GFNM6ZTQC1Q
https://hdl.handle.net/1854/LU-01GS866C80CYSP9GFNM6ZTQC1Q
Autor:
Sijie, Huang, Peiyu, Xu, Dan-Dan, Shen, Icaro A, Simon, Chunyou, Mao, Yangxia, Tan, Huibing, Zhang, Kasper, Harpsøe, Huadong, Li, Yumu, Zhang, Chongzhao, You, Xuekui, Yu, Yi, Jiang, Yan, Zhang, David E, Gloriam, H Eric, Xu
Publikováno v:
Molecular cell. 82(14)
Serotonin (or 5-hydroxytryptamine, 5-HT) is an important neurotransmitter that activates 12 different G protein-coupled receptors (GPCRs) through selective coupling of G