Adaptive Immune Responses Contribute to Post-ischemic Cardiac Remodeling

Autor: Icia Santos-Zas, Jérémie Lemarié, Alain Tedgui, Hafid Ait-Oufella

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 5 (2019)

Myocardial infarction (MI) is a common condition responsible for mortality and morbidity related to ischemic heart failure. Accumulating experimental and translational evidence support a crucial role for innate immunity in heart failure and adverse h

Externí odkaz: https://doaj.org/article/bf94231699ef4fa483c61a4e469282fc

Obestatin signalling counteracts glucocorticoid‐induced skeletal muscle atrophy via NEDD4/KLF15 axis

Autor: Vincent Mouly, José Luis Relova, Saul Leal-lopez, Jesus P. Camiña, Manuel E. Rodríguez‐Fuentes, Icía Santos-Zas, Luis J. Andrade‐Bulos, Jessica González-Sánchez, Yolanda Pazos, Carlos S. Mosteiro, Xesús Casabiell, Tania Cid-Díaz, Fátima Fernández‐Barreiro

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 2, Pp 493-505 (2021)
Journal of Cachexia, Sarcopenia and Muscle
Journal of Cachexia, Sarcopenia and Muscle, In press, ⟨10.1002/jcsm.12677⟩
Journal of Cachexia, Sarcopenia and Muscle, Wiley Open Access/Springer Verlag, In press, ⟨10.1002/jcsm.12677⟩
Journal of Cachexia, Sarcopenia and Muscle, Wiley Open Access/Springer Verlag, 2021, 12 (2), pp.493-505. ⟨10.1002/jcsm.12677⟩

International audience; Background: A therapeutic approach for the treatment of glucocorticoid‐induced skeletal muscle atrophy should be based on the knowledge of the molecular mechanisms determining the unbalance between anabolic and catabolic pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb3ea29729724ef9bd54613290241f11
https://doaj.org/article/6aba5e89c5064f319ade19594e974fcf

Plasma and genetic determinants of soluble TREM-1 and major adverse cardiovascular events in a prospective cohort of acute myocardial infarction patients. Results from the FAST-MI 2010 study

Autor: Salma Kotti, Alain Tedgui, Marie Vandestienne, Marc Derive, Adrien Georges, François Roubille, Sébastien Gibot, Icía Santos-Zas, Nicolas Danchin, Hafid Ait-Oufella, Nabila Bouatia-Naji, Jérémie Joffre, Denis Angoulvant, Tabassome Simon, Mengyao Yu

Publikováno v: International Journal of Cardiology
International Journal of Cardiology, In press, S0167-5273 (21), pp.01379-6. ⟨10.1016/j.ijcard.2021.09.018⟩
International Journal of Cardiology, Elsevier, In press, S0167-5273 (21), pp.01379-6. ⟨10.1016/j.ijcard.2021.09.018⟩

International audience; Introduction: Triggering receptor expressing on myeloid cells (TREM)-1 is involved in the pathophysiology of ischemic heart disease. Plasma soluble TREM-1 levels (sTREM-1) has been associated with increased risk of major adver

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::819c16e4a81d9c0a7e716c06578ed6c7
https://hal.science/hal-03350417

Genetic inhibition of CARD9 accelerates the development of atherosclerosis in mice through CD36 dependent-defective autophagy

Autor: Yujiao Zhang, Marie Vandestienne, Jean-Rémi Lavillegrand, Jeremie Joffre, Icia Santos-Zas, Aonghus Lavelle, Xiaodan Zhong, Wilfried Le Goff, Maryse Guérin, Rida Al-Rifai, Ludivine Laurans, Patrick Bruneval, Coralie Guérin, Marc Diedisheim, Melanie Migaud, Anne Puel, Fanny Lanternier, Jean-Laurent Casanova, Clément Cochain, Alma Zernecke, Antoine-Emmanuel Saliba, Michal Mokry, Jean-Sebastien Silvestre, Alain Tedgui, Ziad Mallat, Soraya Taleb, Olivia Lenoir, Cécile Vindis, Stéphane M. Camus, Harry Sokol, Hafid Ait-Oufella

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

Abstract Caspase recruitment-domain containing protein 9 (CARD9) is a key signaling pathway in macrophages but its role in atherosclerosis is still poorly understood. Global deletion of Card9 in Apoe -/- mice as well as hematopoietic deletion in Ldlr

Externí odkaz: https://doaj.org/article/b269b498eb06438890385181c12ba8bb

β-Arrestin scaffolds and signaling elements essential for the obestatin/GPR39 system that determine the myogenic program in human myoblast cells

Autor: Carlos S. Mosteiro, Tania Cid-Díaz, Rosalía Gallego, Yolanda Pazos, Monica Bouzo-Lorenzo, Xesús Casabiell, Icía Santos-Zas, Vincent Mouly, José Señarís, Felipe F. Casanueva, Uxía Gurriarán-Rodríguez, Jesus P. Camiña, Gabriela Figueroa, Jessica González-Sánchez

Publikováno v: Cellular and Molecular Life Sciences. 73:617-635

Obestatin/GPR39 signaling stimulates skeletal muscle repair by inducing the expansion of satellite stem cells as well as myofiber hypertrophy. Here, we describe that the obestatin/GPR39 system acts as autocrine/paracrine factor on human myogenesis. O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::354467b645ecf57c04772737df22d166
https://doi.org/10.1007/s00018-015-1994-z