Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Ibukun Mary Folorunso"'
1
Akademický článek
Morin hydrate promotes nephrin expression through modulation of Notch1-Snail signalling pathway in diabetic rats
Autor: Akeem Olalekan Lawal, Ibukun Mary Folorunso, Olufemi Adebisi, Omowumi Funmilayo Koledoye, Opeyemi Iwaloye
Publikováno v: Aspects of Molecular Medicine, Vol 2, Iss , Pp 100019- (2023)
Reduction in nephrin expression is usually observed in patients with diabetic nephropathy, and there is evidence that Notch1/Snail signalling pathway is essential for the expression of nephrin. This study investigated the role of morin hydrate (MH) o
Externí odkaz: https://doaj.org/article/b623ffabd27a42ec9305b910a10444db
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2
Akademický článek
Computer-aided drug design in anti-cancer drug discovery: What have we learnt and what is the way forward?
Autor: Opeyemi Iwaloye, Paul Olamide Ottu, Femi Olawale, Olorunfemi Oyewole Babalola, Olusola Olalekan Elekofehinti, Babatomiwa Kikiowo, Abayomi Emmanuel Adegboyega, Henry Nnaemeka Ogbonna, Covenant Femi Adeboboye, Ibukun Mary Folorunso, Aderonke Elizabeth Fakayode, Moses Orimoloye Akinjiyan, Sunday Amos Onikanni, Sergey Shityakov
Publikováno v: Informatics in Medicine Unlocked, Vol 41, Iss , Pp 101332- (2023)
The escalating prevalence of cancer on a global scale, coupled with the inadequacies of present-day therapies and the emergence of drug-resistant cancer strains, has necessitated the development of additional anticancer drugs. The traditional drug di
Externí odkaz: https://doaj.org/article/6cb83284931b4498a720fa901f2146ec
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3
Fragment-Based Drug Design, 2D-QSAR and DFT Calculation: Scaffolds of 1, 2, 4, triazolo [1, 5-a] pyrimidin-7-amines as Potential Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase
Autor: Opeyemi Iwaloye, Olusola Olalekan Elekofehinti, Femi Olawale, Prosper Obed Chukwuemeka, Babatomiwa Kikiowo, Ibukun Mary Folorunso
Publikováno v: Letters in Drug Design & Discovery. 20:317-334
Background: Plasmodium falciparum dihydroorotate dehydrogenase (PfDODH) is one of the enzymes currently explored in the treatment of malaria. Although there is currently no clinically approved drug targeting PfDODH, many of the compounds in clinical
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a1df9af086bd7ce64b9d32dc67dceb7c
https://doi.org/10.2174/1570180819666220422120707
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6
In silico High-Throughput Screening of ZINC Database of Natural Compounds to Identify Novel Histone Deacetylase Inhibitors
Autor: Femi Olawale, Opeyemi Iwaloye, Ibukun Mary Folorunso, Sergey Shityakov
Publikováno v: Journal of Computational Biophysics and Chemistry. 22:11-30
Histone deacetylase 8 (HDAC8) is a zinc-binding metalloprotein being involved in transcriptional regulation, cell cycle progression and cellular development. Its overexpression is associated with various pathologies, including childhood neuroblastoma
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::061ffb0c3e1b092ec3e38562d819a39a
https://doi.org/10.1142/s2737416522500466
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9
Newly designed compounds from scaffolds of known actives as inhibitors of survivin: computational analysis from the perspective of fragment-based drug design
Autor: Femi Olawale, Opeyemi Iwaloye, Prosper Obed Chukwuemeka, Olusola Olalekan Elekofehinti, Ibukun Mary Folorunso
Publikováno v: In Silico Pharmacol
Survivin is an apoptosis suppressing protein linked to different forms of cancer. As it stands, there are no approved drugs for the inhibition of survivin in cancer cells despite a number of promising compounds in clinical trials. This study designed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2334fbf6f607370f501a02cc818eba8
https://doi.org/10.1007/s40203-021-00108-8
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