Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ibtissem, Nabti"'
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Sister chromatid cohesion during meiosis II (MII), maintained by securin-mediated inhibition of separase, is reduced in aged mouse oocytes. Here the authors show that, in MII oocytes, securin levels are reduced by increased destruction by the anaphas
Externí odkaz:
https://doaj.org/article/3a4e763ec2524631b9b17f9c947198cb
Autor:
Ibtissem Nabti, Babu J. N. Reddy, Rachid Rezgui, Wenqi Wang, Steven P. Gross, George T. Shubeita
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Regulation of organelle transport by molecular motors along the cytoskeletal microtubules is central to maintaining cellular functions. Here, we show that the ubiquitous tau-related microtubule-associated protein 4 (MAP4) can bias the bidirectional t
Autor:
Ibtissem Nabti, George T. Shubeita, Fatima S M Refai, Yanthe E. Pearson, Xin Xie, C.U. Murade, Kristin C. Gunsalus, Samata Chaudhuri, Hala Fahs
Publikováno v:
ACS Sensors. 6:2233-2240
Molecules that bind DNA by intercalating its bases remain among the most potent cancer therapies and antimicrobials due to their interference with DNA-processing proteins. To accelerate the discovery of novel intercalating drugs, we designed a fluore
Autor:
Ibtissem Nabti, Babu Reddy Janakaloti Narayanareddy, Rachid Rezgui, Wenqi Wang, Steven Gross, George T. Shubeita
Publikováno v:
Biophysical Journal. 122:26a
Autor:
Guilherme Nettesheim, Gabriel R. Jaffe, C.U. Murade, George T. Shubeita, Ibtissem Nabti, Stephen J. King
Publikováno v:
Nature Physics. 16:1144-1151
Eukaryotic cell processes depend on molecular motors to transport cargo along cytoskeletal filaments, and the response of these mechanoenzymes to external forces shapes their cellular function. These responses have been largely mapped out in dilute,
Autor:
Chandrashekhar U, Murade, Samata, Chaudhuri, Ibtissem, Nabti, Hala, Fahs, Fatima S M, Refai, Xin, Xie, Yanthe E, Pearson, Kristin C, Gunsalus, George T, Shubeita
Publikováno v:
ACS sensors. 6(6)
Molecules that bind DNA by intercalating its bases remain among the most potent cancer therapies and antimicrobials due to their interference with DNA-processing proteins. To accelerate the discovery of novel intercalating drugs, we designed a fluore
Autor:
Deepak Adhikari, Marco Conti, Qing-Hua Zhang, Jennifer A. Flegg, John L. Carroll, Ibtissem Nabti, Greg FitzHarris, Wai Shan Yuen, Piotr Sicinski, Petros Marangos
Publikováno v:
The Journal of Cell Biology
The role of the Cdk regulatory protein cyclin A2 and its dynamics in female meiosis are unclear. Zhang et al. show that, unlike in mitosis, cyclin A2 persists during metaphase of meiosis II (MII). Cyclin A2 regulates microtubule stability, allows nor
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Sister chromatid attachment during meiosis II (MII) is maintained by securin-mediated inhibition of separase. In maternal ageing, oocytes show increased inter-sister kinetochore distance and premature sister chromatid separation (PSCS), suggesting ab
Publikováno v:
Developmental Biology. 321(2):379-386
Mammalian eggs remain arrested at metaphase of the second meiotic division (metII) for an indeterminate time before fertilization. During this period, which can last several hours, the continued attachment of sister chromatids is thought to be achiev
Publikováno v:
Nature Cell Biology. 9:1192-1198
The first female meiotic division (meiosis I, MI) is uniquely prone to chromosome segregation errors through non-disjunction, resulting in trisomies and early pregnancy loss. Here, we show a fundamental difference in the control of mammalian meiosis