GWAS for executive function and processing speed suggests involvement of the CADM2 gene

Autor: Ibrahim-Verbaas, CA, Bressler, J, Debette, S, Schuur, M, Smith, AV, Bis, JC, Davies, G, Trompet, S, Smith, JA, Wolf, C, Chibnik, LB, Liu, Y, Vitart, V, Kirin, M, Petrovic, K, Polasek, O, Zgaga, L, Fawns-Ritchie, C, Hoffmann, P, Karjalainen, J, Lahti, J, Llewellyn, DJ, Schmidt, CO, Mather, KA, Chouraki, V, Sun, Q, Resnick, SM, Rose, LM, Oldmeadow, C, Stewart, M, Smith, BH, Gudnason, V, Yang, Q, Mirza, SS, Jukema, JW, deJager, PL, Harris, TB, Liewald, DC, Amin, N, Coker, LH, Stegle, O, Lopez, OL, Schmidt, R, Teumer, A, Ford, I, Karbalai, N, Becker, JT, Jonsdottir, MK, Au, R, Fehrmann, Rsn, Herms, S, Nalls, M, Zhao, W, Turner, ST, Yaffe, K, Lohman, K, van Swieten, JC, Kardia, Slr, Knopman, DS, Meeks, WM, Heiss, G, Holliday, EG, Schofield, PW, Tanaka, T, Stott, DJ, Wang, J, Ridker, P, Gow, AJ, Pattie, A, Starr, JM, Hocking, LJ, Armstrong, NJ, McLachlan, S, Shulman, JM, Pilling, LC, Eiriksdottir, G, Scott, RJ, Kochan, NA, Palotie, A, Hsieh, Y-C, Eriksson, JG, Penman, A, Gottesman, RF, Oostra, BA, Yu, L, DeStefano, AL, Beiser, A, Garcia, M, Rotter, JI, Nöthen, MM, Hofman, A, Slagboom, PE, Westendorp, Rgj, Buckley, BM, Wolf, PA, Uitterlinden, AG, Psaty, BM, Grabe, HJ, Bandinelli, S, Chasman, DI

Publikováno v: Molecular psychiatry, vol 21, iss 2

To identify common variants contributing to normal variation in two specific domains of cognitive functioning, we conducted a genome-wide association study (GWAS) of executive functioning and information processing speed in non-demented older adults

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::52c0df7312cccfcd4035cf69242b2802
https://escholarship.org/uc/item/7d8152n1

Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949)

Autor: Davies, G, Armstrong, N, Bis, JC, Bressler, J, Chouraki, V, Giddaluru, S, Hofer, E, Ibrahim-Verbaas, CA, Kirin, M, Lahti, J, van der Lee, SJ, Le Hellard, S, Liu, T, Marioni, RE, Oldmeadow, C, Postmus, I, Smith, AV, Smith, JA, Thalamuthu, A, Thomson, R, Vitart, V, Wang, J, Yu, L, Zgaga, L, Zhao, W, Boxall, R, Harris, SE, Hill, WD, Liewald, DC, Luciano, M, Adams, H, Ames, D, Amin, N, Amouyel, P, Assareh, AA, Au, R, Becker, JT, Beiser, A, Berr, C, Bertram, L, Boerwinkle, E, Buckley, BM, Campbell, H, Corley, J, De Jager, PL, Dufouil, C, Eriksson, JG, Espeseth, T, Faul, JD, Ford, I, Generation Scotland, Gottesman, RF, Griswold, ME, Gudnason, V, Harris, TB, Heiss, G, Hofman, A, Holliday, EG, Huffman, J, Kardia, SLR, Kochan, N, Knopman, DS, Kwok, JB, Lambert, J-C, Lee, T, Li, G, Li, S-C, Loitfelder, M, Lopez, OL, Lundervold, AJ, Lundqvist, A, Mather, KA, Mirza, SS, Nyberg, L, Oostra, BA, Palotie, A, Papenberg, G, Pattie, A, Petrovic, K, Polasek, O, Psaty, BM, Redmond, P, Reppermund, S, Rotter, JI, Schmidt, H, Schuur, M, Schofield, PW, Scott, RJ, Steen, VM, Stott, DJ, van Swieten, JC, Taylor, KD, Trollor, J, Trompet, S, Uitterlinden, AG, Weinstein, G, Widen, E, Windham, BG, Jukema, JW, Wright, AF

Publikováno v: Molecular psychiatry, vol 20, iss 2

General cognitive function is substantially heritable across the human life course from adolescence to old age. We investigated the genetic contribution to variation in this important, health- and well-being-related trait in middle-aged and older adu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e4faf92e84ee9c023cc8a4990e7362b0
https://escholarship.org/uc/item/1195r9dg

Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI

Autor: Verhaaren, BFJ, Debette, S, Bis, JC, Smith, JA, Ikram, MK, Adams, HH, Beecham, AH, Rajan, KB, Lopez, LM, Barral, S, Van Buchem, MA, Van Der Grond, J, Smith, AV, Hegenscheid, K, Aggarwal, NT, De Andrade, M, Atkinson, EJ, Beekman, M, Beiser, AS, Blanton, SH, Boerwinkle, E, Brickman, AM, Bryan, RN, Chauhan, G, Chen, CPLH, Chouraki, V, De Craen, AJM, Crivello, F, Deary, IJ, Deelen, J, De Jager, PL, Dufouil, C, Elkind, MSV, Evans, DA, Freudenberger, P, Gottesman, RF, Gunason, V, Habes, M, Heckbert, SR, Heiss, G, Hilal, S, Hofer, E, Hofman, A, Ibrahim-Verbaas, CA, Knopman, DS, Lewis, CE, Liao, J, Liewald, DCM, Luciano, M, Van Der Lugt, A, Martinez, OO, Mayeux, R, Mazoyer, B, Nalls, M, Nauck, M, Niessen, WJ, Oostra, BA, Psaty, BM, Rice, KM, Rotter, JI, Von Sarnowski, B, Schmidt, H, Schreiner, PJ, Schuur, M, Sidney, SS, Sigurdsson, S, Slagboom, PE, Stott, DJM, Van Swieten, JC, Teumer, A, Töglhofer, AM, Traylor, M, Trompet, S, Turner, ST, Tzourio, C, Uh, HW, Uitterlinden, AG, Vernooij, MW, Wang, JJ, Wong, TY, Wardlaw, JM, Windham, BG, Wittfeld, K, Wolf, C, Wright, CB, Yang, Q, Zhao, W, Zijdenbos, A, Jukema, JW, Sacco, RL, Kardia, SLR, Amouyel, P, Mosley, TH, Longstreth, WT, DeCarli, CC, Van Duijn, CM, Schmidt, R, Launer, LJ, Grabe, HJ

Publikováno v: Verhaaren, BFJ; Debette, S; Bis, JC; Smith, JA; Ikram, MK; Adams, HH; et al.(2015). Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI. Circulation: Cardiovascular Genetics, 8(2), 398-409. doi: 10.1161/CIRCGENETICS.114.000858. UCLA: Retrieved from: http://www.escholarship.org/uc/item/7fq176q6

© 2015 American Heart Association, Inc. Background-The burden of cerebral white matter hyperintensities (WMH) is associated with an increased risk of stroke, dementia, and death. WMH are highly heritable, but their genetic underpinnings are incomple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::3605a7101c3d65aad35c5b43af70dea1
http://www.escholarship.org/uc/item/7fq176q6

Interaction of insulin and PPAR-α genes in Alzheimer's disease: the Epistasis Project

Autor: Kölsch, H, Lehmann, DJ, Ibrahim-Verbaas, CA, Combarros, O, Van Duijn, CM, Hammond, N, Belbin, O, Cortina-Borja, M, Lehmann, MG, Aulchenko, YS, Schuur, M, Breteler, M, Wilcock, GK, Brown, K, Kehoe, PG, Barber, R, Coto, E, Alvarez, V, Deloukas, P, Mateo, I, Maier, W, Morgan, K, Warden, DR, Smith, AD, Heun, R

Publikováno v: Journal of Neural Transmission, 119(4), 473-479. Springer Verlag
Journal of Neural Transmission, 119(4), 473-479. Springer-Verlag
Scopus
RUO: Repositorio Institucional de la Universidad de Oviedo
Universidad de Oviedo (UNIOVI)
Kölsch, H, Lehmann, D J, Ibrahim-Verbaas, C A, Combarros, O, Van Duijn, C M, Hammond, N, Belbin, O, Cortina-Borja, M, Lehmann, M G, Aulchenko, Y S, Schuur, M, Breteler, M, Wilcock, G K, Brown, K, Kehoe, P G, Barber, R, Coto, E, Alvarez, V, Deloukas, P, Mateo, I, Maier, W, Morgan, K, Warden, D R, Smith, A D & Heun, R 2012, ' Interaction of insulin and PPAR-α genes in Alzheimer's disease : The Epistasis Project ', Journal of Neural Transmission, vol. 119, no. 4, pp. 473-479 . https://doi.org/10.1007/s00702-011-0732-4
RUO. Repositorio Institucional de la Universidad de Oviedo
instname

We are most grateful to the Moulton Charitable Foundation for a grant to fund the Epistasis Project, to all those who have provided support for the individual clinical studies and to the Alzheimer’s Research Trust. GKW was partly funded by the NIHR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5424dc843dbf8fe6ae172a6cf9f4da13
http://ora.ox.ac.uk/objects/uuid:07f6a714-c8d8-4a68-b5e5-b6d2aee49319

Identification of novel risk loci and causal insights for sporadic Creutzfeldt-Jakob disease: a genome-wide association study.

Autor: Jones E; Medical Research Council Prion Unit, University College London Institute of Prion Diseases, London, UK., Hummerich H; Medical Research Council Prion Unit, University College London Institute of Prion Diseases, London, UK., Viré E; Medical Research Council Prion Unit, University College London Institute of Prion Diseases, London, UK., Uphill J; Medical Research Council Prion Unit, University College London Institute of Prion Diseases, London, UK., Dimitriadis A; Medical Research Council Prion Unit, University College London Institute of Prion Diseases, London, UK., Speedy H; Medical Research Council Prion Unit, University College London Institute of Prion Diseases, London, UK., Campbell T; Medical Research Council Prion Unit, University College London Institute of Prion Diseases, London, UK., Norsworthy P; Medical Research Council Prion Unit, University College London Institute of Prion Diseases, London, UK., Quinn L; Medical Research Council Prion Unit, University College London Institute of Prion Diseases, London, UK., Whitfield J; Medical Research Council Prion Unit, University College London Institute of Prion Diseases, London, UK., Linehan J; Medical Research Council Prion Unit, University College London Institute of Prion Diseases, London, UK., Jaunmuktane Z; Division of Neuropathology, University College London Hospitals National Health Service Foundation Trust, London, UK; Department of Clinical and Movement Neurosciences and Queen Square Brain Bank for Neurological Disorders, University College London Queen Square Institute of Neurology, London, UK., Brandner S; Division of Neuropathology, University College London Hospitals National Health Service Foundation Trust, London, UK; Department of Neurodegenerative Disease, University College London Queen Square Institute of Neurology, London, UK., Jat P; Medical Research Council Prion Unit, University College London Institute of Prion Diseases, London, UK., Nihat A; Medical Research Council Prion Unit, University College London Institute of Prion Diseases, London, UK; National Prion Clinic, University College London Hospitals National Health Service Foundation Trust, London, UK., How Mok T; Medical Research Council Prion Unit, University College London Institute of Prion Diseases, London, UK; National Prion Clinic, University College London Hospitals National Health Service Foundation Trust, London, UK., Ahmed P; Medical Research Council Prion Unit, University College London Institute of Prion Diseases, London, UK., Collins S; Australian National Creutzfeldt-Jakob Disease Registry, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia., Stehmann C; Australian National Creutzfeldt-Jakob Disease Registry, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia., Sarros S; Australian National Creutzfeldt-Jakob Disease Registry, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia., Kovacs GG; Institute of Neurology, Medical University of Vienna, Vienna, Austria; Department of Laboratory Medicine and Pathobiology and Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, ON, Canada; Laboratory Medicine Program, Krembil Brain Institute, University Health Network, Toronto, ON, Canada., Geschwind MD; University of California San Francisco Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA., Golubjatnikov A; University of California San Francisco Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA., Frontzek K; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Budka H; Institute of Neuropathology, University of Zurich, Zurich, Switzerland; Medical University Vienna, Vienna, Austria., Aguzzi A; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Karamujić-Čomić H; Department of Epidemiology, Erasmus Medical Centre, Rotterdam, Netherlands., van der Lee SJ; Department of Epidemiology, Erasmus Medical Centre, Rotterdam, Netherlands., Ibrahim-Verbaas CA; Department of Epidemiology, Erasmus Medical Centre, Rotterdam, Netherlands., van Duijn CM; Department of Epidemiology, Erasmus Medical Centre, Rotterdam, Netherlands; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Sikorska B; Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Lodz, Poland., Golanska E; Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Lodz, Poland., Liberski PP; Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Lodz, Poland., Calero M; Chronic Disease Programme (UFIEC-CROSADIS) and Network Centre for Biomedical Research in Neurodegenerative Diseases (CIBERNED), and Alzheimer Disease Research Unit, CIEN Foundation, Queen Sofia Foundation Alzheimer Centre, Instituto de Salud Carlos III, Madrid, Spain., Calero O; Chronic Disease Programme (UFIEC-CROSADIS) and Network Centre for Biomedical Research in Neurodegenerative Diseases (CIBERNED), and Alzheimer Disease Research Unit, CIEN Foundation, Queen Sofia Foundation Alzheimer Centre, Instituto de Salud Carlos III, Madrid, Spain., Sanchez-Juan P; Neurology Service, University Hospital Marqués de Valdecilla, University of Cantabria, CIBERNED and IDIVAL, Santander, Spain., Salas A; Unidade de Xenética, Instituto de Ciencias Forenses (INCIFOR), Facultade de Medicina, Universidade de Santiago de Compostela, and GenPoB Research Group, Instituto de Investigaciones Sanitarias (IDIS), Hospital Clínico Universitario de Santiago (SERGAS), Galicia, Spain., Martinón-Torres F; Translational Paediatrics and Infectious Diseases, Department of Paediatrics, Hospital Clínico Universitario de Santiago de Compostela, Galicia, Spain., Bouaziz-Amar E; Department of Biochemistry and Molecular Biology, Lariboisière Hospital, AP-HP, University of Paris, Paris, France., Haïk S; Sorbonne Université, INSERM U1127, CNRS UMR 7225, Institut du Cerveau et de la Moelle épinière, Paris, France; Cellule nationale de référence des maladies de Creutzfeldt-Jakob, AP-HP, University Hospital Pitié-Salpêtrière, Paris, France., Laplanche JL; Department of Biochemistry and Molecular Biology, Lariboisière Hospital, AP-HP, University of Paris, Paris, France., Brandel JP; Sorbonne Université, INSERM U1127, CNRS UMR 7225, Institut du Cerveau et de la Moelle épinière, Paris, France; Cellule nationale de référence des maladies de Creutzfeldt-Jakob, AP-HP, University Hospital Pitié-Salpêtrière, Paris, France., Amouyel P; INSERM, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE, Labex DISTALZ, University of Lille, Lille, France., Lambert JC; INSERM, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE, Labex DISTALZ, University of Lille, Lille, France., Parchi P; IRCCS, Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy; Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna, Bologna, Italy., Bartoletti-Stella A; IRCCS, Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy., Capellari S; IRCCS, Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy., Poleggi A; Department of Neuroscience, Istituto Superiore di Sanità, Rome, Italy., Ladogana A; Department of Neuroscience, Istituto Superiore di Sanità, Rome, Italy., Pocchiari M; Department of Neuroscience, Istituto Superiore di Sanità, Rome, Italy., Aneli S; Department of Medical Sciences, Università degli studi di Torino, Torino, Italy., Matullo G; Department of Medical Sciences, Università degli studi di Torino, Torino, Italy., Knight R; National Creutzfeldt-Jakob Disease Research and Surveillance Unit, Edinburgh, UK., Zafar S; Department of Neurology, Clinical Dementia Centre and National Reference Centre for Creutzfeldt-Jakob Disease Surveillance, University Medical School, Göttingen, Germany; German Centre for Neurodegenerative Diseases (DZNE), Göttingen, Germany; Biomedical Engineering and Sciences Department, School of Mechanical and Manufacturing Engineering, National University of Sciences and Technology, Islamabad, Pakistan., Zerr I; Department of Neurology, Clinical Dementia Centre and National Reference Centre for Creutzfeldt-Jakob Disease Surveillance, University Medical School, Göttingen, Germany; German Centre for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Booth S; Prion Disease Program, Public Health Agency of Canada, Winnipeg, MB, Canada., Coulthart MB; Canadian Creutzfeldt-Jakob Disease Surveillance System, Public Health Agency of Canada, Ottawa, ON, Canada., Jansen GH; Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, ON, Canada., Glisic K; Departments of Pathology and Neurology, Case Western Reserve University, Cleveland, OH, USA; National Prion Disease Pathology Surveillance Center, Case Western Reserve University, Cleveland, OH, USA., Blevins J; Departments of Pathology and Neurology, Case Western Reserve University, Cleveland, OH, USA; National Prion Disease Pathology Surveillance Center, Case Western Reserve University, Cleveland, OH, USA., Gambetti P; Departments of Pathology and Neurology, Case Western Reserve University, Cleveland, OH, USA; National Prion Disease Pathology Surveillance Center, Case Western Reserve University, Cleveland, OH, USA., Safar J; Departments of Pathology and Neurology, Case Western Reserve University, Cleveland, OH, USA; National Prion Disease Pathology Surveillance Center, Case Western Reserve University, Cleveland, OH, USA., Appleby B; Departments of Pathology and Neurology, Case Western Reserve University, Cleveland, OH, USA; National Prion Disease Pathology Surveillance Center, Case Western Reserve University, Cleveland, OH, USA., Collinge J; Medical Research Council Prion Unit, University College London Institute of Prion Diseases, London, UK; National Prion Clinic, University College London Hospitals National Health Service Foundation Trust, London, UK., Mead S; Medical Research Council Prion Unit, University College London Institute of Prion Diseases, London, UK; National Prion Clinic, University College London Hospitals National Health Service Foundation Trust, London, UK. Electronic address: s.mead@prion.ucl.ac.uk.

Publikováno v: The Lancet. Neurology [Lancet Neurol] 2020 Oct; Vol. 19 (10), pp. 840-848. Date of Electronic Publication: 2020 Sep 16.