Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ibrahim Tolaymat"'
Autor:
Ibrahim Dumbuya, Ana Maria Pereira, Ibrahim Tolaymat, Adnan Al Dalaty, Basel Arafat, Matt Webster, Barbara Pierscionek, Mouhamad Khoder, Mohammad Najlah
Publikováno v:
Nanomaterials, Vol 14, Iss 13, p 1133 (2024)
Disulfiram (DS) has been shown to have potent anti-cancer activity; however, it is also characterised by its low water solubility and rapid metabolism in vivo. Biodegradable polylactic-co-glycolic acid (PLGA) polymers have been frequently employed in
Externí odkaz:
https://doaj.org/article/05e03c5a9e5547a99e3bb32e8266f44a
Autor:
Ayşe Kaya, Basel Arafat, Havovi Chichger, Ibrahim Tolaymat, Barbara Pierscionek, Mouhamad Khoder, Mohammad Najlah
Publikováno v:
Pharmaceutics, Vol 16, Iss 1, p 65 (2023)
Zinc diethyldithiocarbamate (Zn (DDC)2), a disulfiram metabolite (anti-alcoholism drug), has shown a strong anti-cancer activity in vitro. However, its application was limited by its low aqueous solubility and rapid metabolism. In this study, the sol
Externí odkaz:
https://doaj.org/article/3cdea75d133b4f15ad9a94e0f6deb8fe
Autor:
Ana Maria Pereira, Ayse Kaya, Dan Alves, Niusha Ansari-Fard, Ibrahim Tolaymat, Basel Arafat, Mohammad Najlah
Publikováno v:
Molecules, Vol 27, Iss 17, p 5600 (2022)
Disulfiram (DS), known as an anti-alcoholism drug, has shown a potent antiviral activity. Still, the potential clinical application of DS is limited by its low water solubility and rapid metabolism. Cyclodextrins (CDs) have been widely used to improv
Externí odkaz:
https://doaj.org/article/8b8272d135004c14b1e03e2f1d784a76
Autor:
Ammar Said Suliman, Mouhamad Khoder, Ibrahim Tolaymat, Matt Webster, Raid G. Alany, Weiguang Wang, Abdelbary Elhissi, Mohammad Najlah
Publikováno v:
Pharmaceutics, Vol 13, Iss 1, p 84 (2021)
Diethyldithiocarbamate Copper II (DDC-Cu) has shown potent anticancer activity against a wide range of cancer cells, but further investigations are hindered by its practical insolubility in water. In this study, inclusion complexes of DDC-Cu with hyd
Externí odkaz:
https://doaj.org/article/bbc774cd54a942049565fd2f2b6443a3
Autor:
Ibrahim Tolaymat, Abdelbary Elhissi, Kirsty Palmer, Ammar Said Suliman, Husam M. Younes, Basel Arafat, Rose Tom, Mohammad Najlah
Publikováno v:
Pharmaceutical Development and Technology. 25:579-587
© 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group. In this study, two licensed total parenteral nanoemulsion formulations (Clinoleic® and Intralipid®) were loaded with ciprofloxacin (CP). The physicochemical characteristics and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6ba6ebe10ae5332e75dc32f646c4ca7
https://doi.org/10.1080/10837450.2020.1720237
https://doi.org/10.1080/10837450.2020.1720237
Autor:
Mohammad Najlah, Matt Webster, Raid G. Alany, Ibrahim Tolaymat, Abdelbary Elhissi, Mouhamad Khoder, Weiguang Wang, Ammar Said Suliman
Publikováno v:
Pharmaceutics
Volume 13
Issue 1
Pharmaceutics, Vol 13, Iss 84, p 84 (2021)
Volume 13
Issue 1
Pharmaceutics, Vol 13, Iss 84, p 84 (2021)
Diethyldithiocarbamate Copper II (DDC-Cu) has shown potent anticancer activity against a wide range of cancer cells, but further investigations are hindered by its practical insolubility in water. In this study, inclusion complexes of DDC-Cu with hyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe772315c5cfff66263c5216a7ad197d
https://eprints.kingston.ac.uk/id/eprint/48010/7/Khoder-M-48010-VoR.pdf
https://eprints.kingston.ac.uk/id/eprint/48010/7/Khoder-M-48010-VoR.pdf
Autor:
Saurabh Prabhu, Farzana Rowther, Joseph Hayes, Tracy Warr, Timothy J. Snape, Christopher Sherer, David R Adams, Ibrahim Tolaymat
Publikováno v:
MedChemComm. 9:1850-1861
Glioblastoma is a devastating disease of the brain and is the most common malignant primary brain tumour in adults. The prognosis for patients is very poor with median time of survival after diagnosis measured in months, due in part to the tumours be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5221f8631ad0ea5e3c9f6339c32b6d6
https://doi.org/10.1039/c8md00436f
https://doi.org/10.1039/c8md00436f
Autor:
Mohammad Najlah, Ammar Said Suliman, Ibrahim Tolaymat, Vinodh Kannappan, Abdelbary Elhissi, Sathishkumar Kurusamy, Weiguang Wang
Publikováno v:
Pharmaceutics
Volume 11
Issue 11
Volume 11
Issue 11
Disulfiram (DS), an anti-alcoholism medicine, shows strong anti-cancer activity in the laboratory, but the application in clinics for anti-cancer therapy has been limited by its prompt metabolism. Conventional liposomes have shown limited ability to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3942bc5113b583412f016d6c5e19011e
https://arro.anglia.ac.uk/id/eprint/704982/6/Najlah_et_al_2019.pdf
https://arro.anglia.ac.uk/id/eprint/704982/6/Najlah_et_al_2019.pdf
The prognosis for glioblastoma patients is, at best, poor, with the median time of survival after diagnosis measured in months. As such, there is much need for the rapid development of potent and novel treatments. Herein, we report our preliminary fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760fe83883d003149a359a6121e5f4ea
Publikováno v:
Neuro-Oncology. 17:viii13.2-viii13
INTRODUCTION: Current treatments for glioblastoma multiforme (GBM) do not yield large benefits to patients and hence the repurposing of existing medications is a potentially valuable treatment option. Metformin and phenformin have been used for >60 y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3e89662bd64bdd3fc912133f207bf16
https://doi.org/10.1093/neuonc/nov284.63
https://doi.org/10.1093/neuonc/nov284.63