Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis

Autor: Seren, Seda, Rashed Abouzaid, Maha, Eulenberg-Gustavus, Claudia, Hirschfeld, Josefine, Nasr Soliman, Hala, Jerke, Uwe, N'Guessan, Koffi, Dallet-Choisy, Sandrine, Lesner, Adam, Lauritzen, Conni, Schacher, Beate, Eickholz, Peter, Nagy, Nikoletta, Szell, Marta, Croix, Cécile, Viaud-Massuard, Marie-Claude, Al Farraj Aldosari, Abdullah, Ragunatha, Shivanna, Ibrahim Mostafa, Mostafa, Giampieri, Francesca, Battino, Maurizio, Cornillier, Hélène, Lorette, Gérard, Stephan, Jean-Louis, Goizet, Cyril, Pedersen, John, Gauthier, Francis, Jenne, Dieter E., Marchand-Adam, Sylvain, Chapple, Iain L., Kettritz, Ralph, Korkmaz, Brice

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 2018, 293 (32), pp.12415-12428. ⟨10.1074/jbc.RA118.001922⟩
Journal of Biological Chemistry 32 (293), 12415-12428. (2018)
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2018, 293 (32), pp.12415-12428. ⟨10.1074/jbc.RA118.001922⟩
The Journal of Biological Chemistry

International audience; Membrane-bound proteinase 3 (PR3m) is the main target antigen of anti-neutrophil cytoplasmic autoantibodies (ANCA) in granulomatosis with polyangiitis, a systemic small-vessel vasculitis. Binding of ANCA to PR3m triggers neutr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9e58f6eace429b980ce329babd8397cf
https://hal.inrae.fr/hal-02628189

Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis.

Autor: Seren S; From the INSERM U-1100, 'Centre d'Etude des Pathologies Respiratoires' and Université de Tours, 37000 Tours, France., Rashed Abouzaid M; the Departments of Oro-Dental Genetics and., Eulenberg-Gustavus C; the Experimental and Clinical Research Center, Charité und Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC), 13125 Berlin, Germany., Hirschfeld J; the Institute of Clinical Sciences, College of Medical and Dental Sciences, Periodontal Research Group, University of Birmingham and Birmingham Community Health Trust, Edgbaston, Birmingham B5 7EG, United Kingdom., Nasr Soliman H; Medical Molecular Genetics, National Research Centre, Cairo 12622, Egypt., Jerke U; the Experimental and Clinical Research Center, Charité und Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC), 13125 Berlin, Germany., N'Guessan K; From the INSERM U-1100, 'Centre d'Etude des Pathologies Respiratoires' and Université de Tours, 37000 Tours, France., Dallet-Choisy S; From the INSERM U-1100, 'Centre d'Etude des Pathologies Respiratoires' and Université de Tours, 37000 Tours, France., Lesner A; the Faculty of Chemistry, University of Gdansk, 80-309 Gdansk, Poland., Lauritzen C; Unizyme Laboratories A/S, 2970 Hørsholm, Denmark., Schacher B; the Department of Periodontology, Johann Wolfgang Goethe-University Frankfurt, 60323 Frankfurt, Germany., Eickholz P; the Department of Periodontology, Johann Wolfgang Goethe-University Frankfurt, 60323 Frankfurt, Germany., Nagy N; the Department of Medical Genetics, University of Szeged, Szeged 6720, Hungary., Szell M; the Department of Medical Genetics, University of Szeged, Szeged 6720, Hungary., Croix C; UMR-CNRS 7292 'Génétique, Immunothérapie, Chimie et Cancer' and Université François Rabelais, 37000 Tours, France., Viaud-Massuard MC; UMR-CNRS 7292 'Génétique, Immunothérapie, Chimie et Cancer' and Université François Rabelais, 37000 Tours, France., Al Farraj Aldosari A; the Department of Prosthetic Dental Science, College of Dentistry, King Saud University, Riyadh 12372, Kingdom of Saudi Arabia., Ragunatha S; the Department of Dermatology, Venereology, and Leprosy, ESIC Medical College and PGIMSR Rajajinagar, Bengaluru, Karnataka 560010, India., Ibrahim Mostafa M; the Departments of Oro-Dental Genetics and., Giampieri F; the Department of Clinical Sciences, Università Politecnica delle Marche, 60121 Ancona, Italy., Battino M; the Department of Clinical Sciences, Università Politecnica delle Marche, 60121 Ancona, Italy., Cornillier H; Service de Dermatologie, Centre Hospitalier Universitaire de Tours, Université de Tours, 37000 Tours, France., Lorette G; UMR-INRA1282 'Laboratoire de Virologie et Immunologie Moléculaires,' Université de Tours, 37000 Tours, France., Stephan JL; the Service d'Hématologie Immunologie et Rhumatologie Pédiatrique, Centre Hospitalier Universitaire de Saint-Etienne, 42270 Saint-Priest-en-Jarez, France., Goizet C; INSERM U-1211, Rare Diseases, Genetic and Metabolism, MRGM Laboratory, Pellegrin Hospital and University, 33000 Bordeaux, France., Pedersen J; Unizyme Laboratories A/S, 2970 Hørsholm, Denmark., Gauthier F; From the INSERM U-1100, 'Centre d'Etude des Pathologies Respiratoires' and Université de Tours, 37000 Tours, France., Jenne DE; the Comprehensive Pneumology Center, Institute of Lung Biology and Disease, German Center for Lung Research (DZL), 81377 Munich, Germany.; the Max Planck Institute of Neurobiology, 82152 Planegg-Martinsried, Germany, and., Marchand-Adam S; From the INSERM U-1100, 'Centre d'Etude des Pathologies Respiratoires' and Université de Tours, 37000 Tours, France., Chapple IL; the Institute of Clinical Sciences, College of Medical and Dental Sciences, Periodontal Research Group, University of Birmingham and Birmingham Community Health Trust, Edgbaston, Birmingham B5 7EG, United Kingdom., Kettritz R; the Experimental and Clinical Research Center, Charité und Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC), 13125 Berlin, Germany.; the Division of Nephrology and Intensive Care Medicine, Medical Department, Charité-Universitätsmedizin, 10117 Berlin, Germany., Korkmaz B; From the INSERM U-1100, 'Centre d'Etude des Pathologies Respiratoires' and Université de Tours, 37000 Tours, France, brice.korkmaz@inserm.fr.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2018 Aug 10; Vol. 293 (32), pp. 12415-12428. Date of Electronic Publication: 2018 Jun 20.