Adhesion protein VSIG1 is required for the proper differentiation of glandular gastric epithelia.

Autor: Odgerel Oidovsambuu, Gunsmaa Nyamsuren, Shuai Liu, Wolfgang Göring, Wolfgang Engel, Ibrahim M Adham

Publikováno v: PLoS ONE, Vol 6, Iss 10, p e25908 (2011)

VSIG1, a cell adhesion protein of the immunoglobulin superfamily, is preferentially expressed in stomach, testis, and certain gastric, esophageal and ovarian cancers. Here, we describe the expression patterns of three alternatively spliced isoforms o

Externí odkaz: https://doaj.org/article/138201e3eb0f44e4984937bbc44517dd

Pelota regulates the development of extraembryonic endoderm through activation of bone morphogenetic protein (BMP) signaling

Autor: Gunsmaa Nyamsuren, Aleksandra Kata, Xingbo Xu, Priyadharsini Raju, Ralf Dressel, Wolfgang Engel, D.V. Krishna Pantakani, Ibrahim M. Adham

Publikováno v: Stem Cell Research, Vol 13, Iss 1, Pp 61-74 (2014)

Pelota (Pelo) is ubiquitously expressed, and its genetic deletion in mice leads to embryonic lethality at an early post-implantation stage. In the present study, we conditionally deleted Pelo and showed that PELO deficiency did not markedly affect th

Externí odkaz: https://doaj.org/article/e7c2da876a454e9bb52dd51843984aaa

Intronic CRISPR Repair in a Preclinical Model of Noonan Syndrome-Associated Cardiomyopathy

Autor: Ibrahim M. Adham, Sebastian Diecke, Robin Hindmarsh, Wolfram-Hubertus Zimmermann, Peter Nürnberg, Ibrahim El-Battrawy, Yun Li, Gabriela Salinas, Lukas Cyganek, Christian D. Muller, Huan Lan, Mandy Kleinsorge, Gerd Hasenfuss, Malte Tiburcy, Boris Barbarics, Bernd Wollnik, Ulrich Hanses, Janine Altmüller, Lennart Roos, Thomas Paul, Christof Lenz, Gökhan Yigit

Publikováno v: Circulation. 142(11)

Background: Noonan syndrome (NS) is a multisystemic developmental disorder characterized by common, clinically variable symptoms, such as typical facial dysmorphisms, short stature, developmental delay, intellectual disability as well as cardiac hype

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2caf8784e2e016ec90a139efeaa0bacf
https://pubmed.ncbi.nlm.nih.gov/32623905

An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis

Autor: Ajay Kumar Mishra, Inês Sequeira, Tony Ly, Harunori Yoshikawa, Angus I. Lamond, Rachel Green, Kifayathullah Liakath-Ali, Fiona M. Watt, Angela Oliveira Pisco, Colin Chih Chien Wu, Kalle Sipilä, Eric W. Mills, Ibrahim M. Adham, Beate M. Lichtenberger

Publikováno v: Liakath-Ali, K, Mills, E W, Sequeira, I, Lichtenberger, B M, Pisco, A O, Sipilä, K H, Mishra, A, Yoshikawa, H, Wu, C C-C, Ly, T, Lamond, A I, Adham, I M, Green, R & Watt, F M 2018, ' An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis ', Nature, vol. 556, pp. 376–380 . https://doi.org/10.1038/s41586-018-0032-3

Ribosome-associated mRNA quality control mechanisms ensure the fidelity of protein translation1,2. Although these mechanisms have been extensively studied in yeast, little is known about their role in mammalian tissues, despite emerging evidence that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc27db998c4bff59dcf2299f067b2ba
https://hdl.handle.net/20.500.11820/1d7a5279-db8a-4439-a96d-485fd01a39b8

Pelota mediates gonocyte maturation and maintenance of spermatogonial stem cells in mouse testes

Autor: Manar Elkenani, Wolfgang Engel, Erdenechimeg Tsagaan, Priyadharsini Raju, Aleksandra Kata, Ibrahim M. Adham, Gunsmaa Nyamsuren

Publikováno v: REPRODUCTION. 149:213-221

Pelota (Pelo) is an evolutionarily conserved gene, and its deficiency inDrosophilaaffects both male and female fertility. In mice, genetic ablation ofPeloleads to embryonic lethality at the early implantation stage as a result of the impaired develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::843d464e3df7ab2abc82d94de19f8c32
https://doi.org/10.1530/rep-14-0391