Výsledky vyhledávání - "Ibrahim M, Adham"

Akademický článek

Heat shock protein A4 ablation leads to skeletal muscle myopathy associated with dysregulated autophagy and induced apoptosis

Autor: Manar Elkenani, Amal Z. Barakat, Torsten Held, Daniel Marques Rodrigues, Sherok Mobarak, Surabhi Swarnka, Ibrahim M. Adham, Belal A. Mohamed

Publikováno v: Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-10 (2022)

Abstract Background Molecular chaperones assist protein folding, facilitate degradation of misfolded polypeptides, and thereby maintain protein homeostasis. Impaired chaperone activity leads to defective protein quality control that is implicated in

Externí odkaz: https://doaj.org/article/8dc60591845c458a975ab700f5e81a40

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Akademický článek

Relaxin Family Member Insulin‐Like Peptide 6 Ameliorates Cardiac Fibrosis and Prevents Cardiac Remodeling in Murine Heart Failure Models

Autor: Sonomi Maruyama, Chia‐Ling Wu, Sumiko Yoshida, Dongying Zhang, Pei‐Hsuan Li, Fangzhou Wu, Jennifer Parker Duffen, Rouan Yao, Blake Jardin, Ibrahim M. Adham, Ronald Law, Joel Berger, Richard Di Marchi, Kenneth Walsh

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 12 (2018)

Background The insulin/insulin‐like growth factor/relaxin family represents a group of structurally related but functionally diverse proteins. The family member relaxin‐2 has been evaluated in clinical trials for its efficacy in the treatment of

Externí odkaz: https://doaj.org/article/2be08108d2164e938f50a03c6886e64b

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Akademický článek

Pelota regulates the development of extraembryonic endoderm through activation of bone morphogenetic protein (BMP) signaling

Autor: Gunsmaa Nyamsuren, Aleksandra Kata, Xingbo Xu, Priyadharsini Raju, Ralf Dressel, Wolfgang Engel, D.V. Krishna Pantakani, Ibrahim M. Adham

Publikováno v: Stem Cell Research, Vol 13, Iss 1, Pp 61-74 (2014)

Pelota (Pelo) is ubiquitously expressed, and its genetic deletion in mice leads to embryonic lethality at an early post-implantation stage. In the present study, we conditionally deleted Pelo and showed that PELO deficiency did not markedly affect th

Externí odkaz: https://doaj.org/article/e7c2da876a454e9bb52dd51843984aaa

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Perturbed differentiation of murine embryonic stem cells upon Pelota deletion due to dysregulated FOXO1/β‐catenin signaling

Autor: Gunsmaa Nyamsuren, Manar Elkenani, Ibrahim M. Adham, Karl Toischer, Belal A. Mohamed

Publikováno v: The FEBS Journal. 288:3317-3329

Differentiation of the embryonic stem cells (ESCs) is regulated by a variety of different signaling pathways. Genetic depletion of murine Pelota gene (Pelo) leads to early embryonic lethality. Here, we aimed at determining the embryonic stage and dec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c89571aa3877a169beb111297aa576
https://doi.org/10.1111/febs.15643

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Intronic CRISPR Repair in a Preclinical Model of Noonan Syndrome-Associated Cardiomyopathy

Publikováno v: Circulation. 142(11)

Background: Noonan syndrome (NS) is a multisystemic developmental disorder characterized by common, clinically variable symptoms, such as typical facial dysmorphisms, short stature, developmental delay, intellectual disability as well as cardiac hype

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2caf8784e2e016ec90a139efeaa0bacf
https://pubmed.ncbi.nlm.nih.gov/32623905

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Akademický článek

Adhesion protein VSIG1 is required for the proper differentiation of glandular gastric epithelia.

Autor: Odgerel Oidovsambuu, Gunsmaa Nyamsuren, Shuai Liu, Wolfgang Göring, Wolfgang Engel, Ibrahim M Adham

Publikováno v: PLoS ONE, Vol 6, Iss 10, p e25908 (2011)

VSIG1, a cell adhesion protein of the immunoglobulin superfamily, is preferentially expressed in stomach, testis, and certain gastric, esophageal and ovarian cancers. Here, we describe the expression patterns of three alternatively spliced isoforms o

Externí odkaz: https://doaj.org/article/138201e3eb0f44e4984937bbc44517dd

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Relaxin Family Member Insulin‐Like Peptide 6 Ameliorates Cardiac Fibrosis and Prevents Cardiac Remodeling in Murine Heart Failure Models

Autor: Pei Hsuan Li, Chia-Ling Wu, Rouan Yao, Ronald E. Law, Richard Di Marchi, Sumiko Yoshida, Kenneth Walsh, Fangzhou Wu, Joel P Berger, Dongying Zhang, Sonomi Maruyama, Blake D. Jardin, Jennifer Parker Duffen, Ibrahim M. Adham

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e80ab3db8f323e0efcf61141809c4bfc
https://doi.org/10.1161/jaha.117.008441

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An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis

Autor: Ajay Kumar Mishra, Inês Sequeira, Tony Ly, Harunori Yoshikawa, Angus I. Lamond, Rachel Green, Kifayathullah Liakath-Ali, Fiona M. Watt, Angela Oliveira Pisco, Colin Chih Chien Wu, Kalle Sipilä, Eric W. Mills, Ibrahim M. Adham, Beate M. Lichtenberger

Publikováno v: Liakath-Ali, K, Mills, E W, Sequeira, I, Lichtenberger, B M, Pisco, A O, Sipilä, K H, Mishra, A, Yoshikawa, H, Wu, C C-C, Ly, T, Lamond, A I, Adham, I M, Green, R & Watt, F M 2018, ' An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis ', Nature, vol. 556, pp. 376–380 . https://doi.org/10.1038/s41586-018-0032-3

Ribosome-associated mRNA quality control mechanisms ensure the fidelity of protein translation1,2. Although these mechanisms have been extensively studied in yeast, little is known about their role in mammalian tissues, despite emerging evidence that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc27db998c4bff59dcf2299f067b2ba
https://hdl.handle.net/20.500.11820/1d7a5279-db8a-4439-a96d-485fd01a39b8

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