Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Ibrahim John Malik"'
Publikováno v:
Cellular and Molecular Neurobiology
Sortilin was first identified based on its activity as part of intracellular protein sorting machinery. Recently, it was discovered that sortilin also acts as a cell surface receptor for the propeptide form of nerve growth factor (proNGF), progranuli
Autor:
Jan J. Enghild, Ebbe Toftgaard Poulsen, Lone Tjener Pallesen, Nádia Gonçalves, Mette Richner, Thomas Hellesøe Holm, Lars Christian Biilmann Rønn, Louis-Etienne Lorenzo, Karin Lykke-Hartmann, Maj Ulrichsen, Christian Bjerggaard Vaegter, Yves De Koninck, Anders Nykjaer, Annie Castonguay, Hande Login, Olav M. Andersen, Ole J. Bjerrum, Ibrahim John Malik
Publikováno v:
Richner, M, Pallesen, L T, Ulrichsen, M, Poulsen, E T, Holm, T H, Login, H, Castonguay, A, Lorenzo, L-E, Gonçalves, N P, Andersen, O M, Lykke-Hartmann, K, Enghild, J J, Rønn, L C B, Malik, I J, De Koninck, Y, Bjerrum, O J, Vægter, C B & Nykjær, A 2019, ' Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain ', Science Advances, vol. 5, no. 6, eaav9946 . https://doi.org/10.1126/sciadv.aav9946
Science Advances
Richner, M, Pallesen, L T, Ulrichsen, M, Poulsen, E T, Holm, T H, Login, H, Castonguay, A, Lorenzo, L E, Gonçalves, N P, Andersen, O M, Lykke-Hartmann, K, Enghild, J J, Rønn, L C B, Malik, I J, De Koninck, Y, Bjerrum, O J, Vægter, C B & Nykjær, A 2019, ' Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain ' Science Advances, vol. 5, no. 6, eaav9946 . https://doi.org/10.1126/sciadv.aav9946
Science Advances
Richner, M, Pallesen, L T, Ulrichsen, M, Poulsen, E T, Holm, T H, Login, H, Castonguay, A, Lorenzo, L E, Gonçalves, N P, Andersen, O M, Lykke-Hartmann, K, Enghild, J J, Rønn, L C B, Malik, I J, De Koninck, Y, Bjerrum, O J, Vægter, C B & Nykjær, A 2019, ' Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain ' Science Advances, vol. 5, no. 6, eaav9946 . https://doi.org/10.1126/sciadv.aav9946
Blocking of sortilin ligand binding prevents neuropathic pain by inhibiting BDNF-induced spinal KCC2 down-regulation.
Neuropathic pain is a major incurable clinical problem resulting from peripheral nerve trauma or disease. A central mechanism i
Neuropathic pain is a major incurable clinical problem resulting from peripheral nerve trauma or disease. A central mechanism i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa3c302ed3cefcb24aca3ae1644e4f52
https://pure.au.dk/portal/da/publications/sortilin-gates-neurotensin-and-bdnf-signaling-to-control-peripheral-neuropathic-pain(81baa09b-5c54-4b82-91e2-6a5fde210696).html
https://pure.au.dk/portal/da/publications/sortilin-gates-neurotensin-and-bdnf-signaling-to-control-peripheral-neuropathic-pain(81baa09b-5c54-4b82-91e2-6a5fde210696).html
Autor:
Søren Christensen, Ibrahim John Malik, Laurent David, Lena Tagmose, Samsa Lindberg, Tenna Juul Schrøder, Durga Rao Sakumudi, Søren Thirup, Klaus Baek Simonsen, Christoffer Bundgaard, Jan Egebjerg, Lars Christian Biilmann Rønn, Jeffrey B. Stavenhagen, Pradheep Eradi, Shiva Prasad Kasturi, Jan Jacobsen, Jørgen Eskildsen, Jacob Andersen, Inge E. M. de Jong, Philip James Maltas, Stephen P. Watson, Sridhar Pervaram, Dorthe Strandbygård, Morten Langgård, Srinivas Uppalanchi, Jens-Jakob Karlsson
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(1)
The identification of the novel, selective, orally bioavailable Sortilin inhibitor AF38469 is described. Structure–activity relationships and syntheses are reported, along with an X-ray crystal structure of the sortilin-AF38469 protein-inhibitor co
Autor:
Jens-Jakob Karlsson, Lars Christian Biilmann Rønn, Ibrahim John Malik, Maria Marta García-Alai, Morten Langgård, Lone Tjener Pallesen, Jan Egebjerg, Lena Tagmose, Philip James Maltas, Steven P. Watson, Durga Rao Sakumudi, Inge E. M. de Jong, Laurent David, Srinivas Uppalanchi, Jørgen Eskildsen, Dorthe Strandbygård, Søren Thirup, Tenna Juul Schrøder, Jacob Andersen, Samsa Lindberg, Pradheep Eradi, Klaus Baek Simonsen, Søren Christensen
Publikováno v:
Acta Crystallographica Section D: Biological Crystallography
Andersen, J L, Schrøder, T J, Christensen, S, Strandbygård, D J, Pallesen, L T, Garcia Alai, M M, Lindberg, S, Langgård, M, Eskildsen, J C, David, L, Tagmose, L, Simonsen, K B, Maltas, P J, Rønn, L C B, de Jong, I E M, Malik, I J, Egebjerg, J, Karlsson, J J, Uppalanchi, S, Sakumudi, D R, Eradi, P, Watson, S P & Thirup, S 2014, ' Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor-ligand complex ', Acta Crystallographica. Section D: Biological Crystallography, vol. 70, no. Part 2, pp. 451-460 . https://doi.org/10.1107/S1399004713030149
Andersen, J L, Schrøder, T J, Christensen, S, Strandbygård, D J, Pallesen, L T, Garcia Alai, M M, Lindberg, S, Langgård, M, Eskildsen, J C, David, L, Tagmose, L, Simonsen, K B, Maltas, P J, Rønn, L C B, de Jong, I E M, Malik, I J, Egebjerg, J, Karlsson, J J, Uppalanchi, S, Sakumudi, D R, Eradi, P, Watson, S P & Thirup, S 2014, ' Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor-ligand complex ', Acta Crystallographica. Section D: Biological Crystallography, vol. 70, no. Part 2, pp. 451-460 . https://doi.org/10.1107/S1399004713030149
The identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor–ligand complex are reported.
Sortilin is a type I membrane glycoprotein belonging to the vacuolar protein sorti
Sortilin is a type I membrane glycoprotein belonging to the vacuolar protein sorti