Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ibrahim El-Hamamy"'
Autor:
Akram A. Hamed, Daniel J. Kunz, Ibrahim El-Hamamy, Quang M. Trinh, Omar D. Subedar, Laura M. Richards, Warren Foltz, Garrett Bullivant, Matthaeus Ware, Maria C. Vladoiu, Jiao Zhang, Antony M. Raj, Trevor J. Pugh, Michael D. Taylor, Sarah A. Teichmann, Lincoln D. Stein, Benjamin D. Simons, Peter B. Dirks
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The link between neural development and tumourigenesis in adult glioma remains unclear. Here, the authors monitor the developmental stages of Sox2 + /− stem cells from a mouse model using single-cell RNA sequencing and suggest the acquisition of em
Externí odkaz:
https://doaj.org/article/808d767b32b241cfad002bab2df3ad6b
Autor:
Jennifer Ocasio, Benjamin Babcock, Daniel Malawsky, Seth J. Weir, Lipin Loo, Jeremy M. Simon, Mark J. Zylka, Duhyeong Hwang, Taylor Dismuke, Marina Sokolsky, Elias P. Rosen, Rajeev Vibhakar, Jiao Zhang, Olivier Saulnier, Maria Vladoiu, Ibrahim El-Hamamy, Lincoln D. Stein, Michael D. Taylor, Kyle S. Smith, Paul A. Northcott, Alejandro Colaneri, Kirk Wilhelmsen, Timothy R. Gershon
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Although the hedgehog (HH) pathway is known to be deregulated in medulloblastoma, inhibitors of the pathway have shown disappointing clinical benefit. Using single-cell sequencing in a mouse model of the disease, the authors show that the response to
Externí odkaz:
https://doaj.org/article/2fac3f5447844cbea3e21cfcf9b5423c
Autor:
Jennifer Karin Ocasio, Benjamin Babcock, Daniel Malawsky, Seth J. Weir, Lipin Loo, Jeremy M. Simon, Mark J. Zylka, Duhyeong Hwang, Taylor Dismuke, Marina Sokolsky, Elias P. Rosen, Rajeev Vibhakar, Jiao Zhang, Olivier Saulnier, Maria Vladoiu, Ibrahim El-Hamamy, Lincoln D. Stein, Michael D. Taylor, Kyle S. Smith, Paul A. Northcott, Alejandro Colaneri, Kirk Wilhelmsen, Timothy R. Gershon
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/c9c57a0e4ea24207a669b99052c30e34
Autor:
Michael D. Taylor, Marina Sokolsky, Daniel S Malawsky, Benjamin Babcock, Duhyeong Hwang, Elias P. Rosen, Jiao Zhang, Jeremy M. Simon, Lipin Loo, Ibrahim El-Hamamy, Jennifer Ocasio, Kyle S. Smith, Rajeev Vibhakar, Mark J. Zylka, Maria C. Vladoiu, Timothy R. Gershon, Olivier Saulnier, Seth J. Weir, Taylor Dismuke, Kirk C. Wilhelmsen, Alejandro Colaneri, Paul A. Northcott, Lincoln Stein
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature Communications
Targeting oncogenic pathways holds promise for brain tumor treatment, but inhibition of Sonic Hedgehog (SHH) signaling has failed in SHH-driven medulloblastoma. Cellular diversity within tumors and reduced lineage commitment can undermine targeted th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::913bf88d556273bc70f19ddff9003a89
https://doaj.org/article/2fac3f5447844cbea3e21cfcf9b5423c
https://doaj.org/article/2fac3f5447844cbea3e21cfcf9b5423c
Autor:
Samuel Weiss, Leo J.Y. Kim, Xiaochong Wu, Randy Van Ommeren, Yanqing Jiang, Kaitlin Kharas, Evgeny Kanshin, Moloud Ahmadi, Alberto Delaidelli, Geneviève Deblois, David Przelicki, Stephane Angers, Hiromichi Suzuki, Sameer Agnihotri, Bradly G. Wouters, Graham MacLeod, Ricky Tsai, Pasqualino De Antonellis, Michelle Ly, Stacey L. Krumholtz, Paul Guilhamon, James Loukides, Ravi N. Vellanki, Alex Rasnitsyn, Hamza Farooq, Daniel Schramek, Nada Jabado, María Sánchez-Osuna, Laura K. Donovan, Vijay Ramaswamy, Ibrahim El-Hamamy, Joonas Haapasalo, Jeremy N. Rich, Michael D. Taylor, Benjamin A. Garcia, Mike Tyers, Kyle Juraschka, Winnie Ong, Olivier Saulnier, Panagiotis Prinos, John J.Y. Lee, Borja L. Holgado, Olga Sirbu, Craig Daniels, Cheryl H. Arrowsmith, Cory Richman, Poul H. Sorensen, Kulandaimanuvel Antony Michealraj, Sheila K. Singh, Andrea Bajic, Polina Balin, Stephen C. Mack, Betty Luu, Fiona J. Coutinho, Dilakshan Srikanthan, Florence M.G. Cavalli, Sachin Kumar, Evan Y. Wang, Mathieu Lupien, Peter B. Dirks, Maria C. Vladoiu, Lincoln Stein, Livia Garzia, Ahmad Malik, John Wojcik, Avesta Rastan
Posterior fossa A (PFA) ependymomas are lethal malignancies of the hindbrain in infants and toddlers. Lacking highly recurrent somatic mutations, PFA ependymomas are proposed to be epigenetically driven tumors for which model systems are lacking. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a4cbadadef8c1b79cfc6c9ec6f333d8
https://hdl.handle.net/11588/900834
https://hdl.handle.net/11588/900834
Autor:
Alexandra L. Joyner, Borja L Holgado, Florence Cavalli, Hamza Farooq, Jennifer A. Chan, Michael D. Taylor, Claudia L. Kleinman, Betty Luu, Nada Jabado, Laura K. Donovan, Lincoln Stein, Maria C. Vladoiu, Vijay Ramaswamy, Ibrahim El-Hamamy
We isolated cells from various points in murine embryonic and early post-ntal cerebellar development (E10 to P14) and undertook single cell RNA sequencing to identify >30 transcriptionally distinct cell populations. Reconstruction of developmental li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da0f38275cb5f3fd377f968abddc32dc
https://europepmc.org/articles/PMC6477449/
https://europepmc.org/articles/PMC6477449/
Autor:
Maria Vladoiu, Ibrahim El-Hamamy, Laura Donovan, Hamza Farooq, Borja Holgado, Faiyaz Notta, Nada Jabado, Lincoln Stein, Michael D Taylor
Single cell RNA-sequencing (scRNAseq) of the murine cerebellum at nine fetal and immediate post-natal (E10-P14) times points on >60,000 individual cells to identified >30 transcriptionally distinct cell clusters. Based on marker gene expression, many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a959220fdfb569f01276285c67eecd6
https://europepmc.org/articles/PMC6477329/
https://europepmc.org/articles/PMC6477329/
Autor:
Ibrahim El-Hamamy, Maria Vladoiu, Laura Donovan, Florence Cavalli, Vijay Ramaswamy, Hamza Farooq, Borja Lopez, Claudia Kleinman, Jennifer Chan, Sheila Singh, Nada Jabado, Lincoln Stein, Michael Taylor
We isolated cells from various points in murine embryonic and early post-natal cerebellar development (E10 to P14) and undertook single cell RNA sequencing to identify >30 transcriptionally distinct cell populations. Reconstruction of developmental l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3387d4d007b4002ed6fc61e24b042ede
https://europepmc.org/articles/PMC6217636/
https://europepmc.org/articles/PMC6217636/
Autor:
Karen Ng, Vijay Ramaswamy, Ibrahim El-Hamamy, Jennifer A. Chan, Trevor J. Pugh, Xiaochong Wu, Vernon Fong, Stephen C. Mack, Sachin Kumar, Maria C. Vladoiu, Laura K. Donovan, Lincoln Stein, Alexandra L. Joyner, Nada Jabado, Livia Garzia, David Malkin, Eric M. Thompson, Antony Michealraj, John J.Y. Lee, Hamza Farooq, Lawrence E. Heisler, Faiyaz Notta, Peter B. Dirks, Liam D. Hendrikse, Sheila K. Singh, Borja L. Holgado, Florence M.G. Cavalli, Betty Luu, Yogi Sundaravadanam, Marco A. Marra, Patryk Skowron, Maleeha Qazi, David Przelicki, Hiromichi Suzuki, Kyle Juraschka, Craig Daniels, A. Sorana Morrissy, Michael D. Taylor, Claudia L. Kleinman
Publikováno v:
Translational Cancer Research
Nature
Nature
Study of the origin and development of cerebellar tumours has been hampered by the complexity and heterogeneity of cerebellar cells that change over the course of development. Here we use single-cell transcriptomics to study more than 60,000 cells fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13efe6bed7d34464fee02e09d45ad6e9
https://pubmed.ncbi.nlm.nih.gov/35117480
https://pubmed.ncbi.nlm.nih.gov/35117480
Autor:
Antony MichaelRaj, David Malkin, Florence Cavalli, Marco A. Marra, Patryk Skowron, Craig Daniels, Maleeha Qazi, Sachin Kumar, Hiromichi Suzuki, Vijay Ramaswamy, Ibrahim El-Hamamy, Maria C. Vladoiu, Livia Garzia, Jennifer A. Chan, Trevor J. Pugh, Faiyaz Notta, Sheila K. Singh, Lincoln Stein, Hamza Farooq, Betty Luu, David Przelicki, Kyle Juraschka, Laura K. Donovan, Sorana Morrissy, Stephen C. Mack, Peter B. Dirks, Nada Jabado, Alexandra L. Joyner, Borja L Holgado, Xiaochong Wu, John J.Y. Lee, Michael D. Taylor, Claudia L. Kleinman
SummaryThe study of the origin and development of cerebellar tumours has been hampered by the complexity and heterogeneity of cerebellar cells that change over the course of development. We used single-cell transcriptomics to study >60,000 cells from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e87a07b0a1ae21c747b479ceef63785a