Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ibrahim D. Bori"'
Autor:
Ibrahim D. Bori, Daniel L. Comins
Publikováno v:
Arkivoc. 2021:57-72
Publikováno v:
Analytical Chemistry. 79:3989-3995
The wide range of protein concentrations found in biological matrixes presents a formidable analytical challenge in proteomics experiments. It is predicted that low-abundance proteins are the likely clinically relevant targets in disease-based proteo
Publikováno v:
Tetrahedron Letters. 46:6697-6699
Lithium–halogen exchange of 2,4-dibromoquinolines proceeds regioselectively at C-4 and affords 4-substituted quinolines on quenching with electrophiles. Palladium-catalyzed cross-coupling reactions of 2-bromo-4-iodoquinoline provide 4-substituted 2
Autor:
Ibrahim D. Bori, Hsin Yi Hung, Kuo Hsiung Lee, Harukuni Tokuda, Nobutaka Suzuki, Akira Iida, Keduo Qian, Kyoko Nakagawa-Goto
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(3)
Ten new 3,4- seco betulinic acid (BA) derivatives were designed and synthesized. Among them, compounds 7 – 15 exhibited enhanced chemopreventive ability in an in vitro short-term 12- O -tetradecanoylphorbol-13-acetate (TPA) induced Epstein–Barr v
Autor:
Kenneth F. Bastow, Yoshiki Kashiwada, Chang Qi Hu, Kuo Hsiung Lee, Ibrahim D. Bori, Susumu Kitanaka, Ichiro Yasuda
Publikováno v:
Journal of Natural Products. 58:1647-1654
Two pleiotropic multi-drug resistant (PDR) KB cell lines were hypersusceptible to a cytotoxic extract from Fatsia japonica. Fractionation of an active extract using a cell-based assay for DNA topoisomerase inhibitors led to the isolation of three kno
In a continuing study of bevirimat (2), the anti-HIV-maturation clinical trials agent, 28 new betulinic acid (BA, 1) derivatives were designed and synthesized. Among these compounds, 17, with a C-28 MEM ester moiety, and 22, with a C-28 ethyl hexanoa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5789ccca02c4d3d5ae0a047b5f8f3ec
https://europepmc.org/articles/PMC3478670/
https://europepmc.org/articles/PMC3478670/
Autor:
Susan L. Morris-Natschke, Kuo Hsiung Lee, Chin Ho Chen, Hsin Yi Hung, Keduo Qian, Ibrahim D. Bori
In the present study, a new strategy to link AZT with betulin/betulinic acid (BA) by click chemistry was designed and achieved. This conjugation via a triazole linkage offers a new direction for modification of anti-HIV triterpenes. Click chemistry p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce08b894cd0370f0a7cab4570baf8c6a
Autor:
Ibrahim D. Bori, I. Nishioka, Kenneth F. Bastow, Yasuhiro Fukushima, Takashi Tanaka, Kuo Hsiung Lee, Yoshiki Kashiwada, Genichiro Nonaka
Publikováno v:
Planta Medica. 59:240-245
Many tannins were previously identified as candidate topoisomerase poisons. Here we report further studies on sanguiin H-6, a dimeric ellagitannin isolated from Sanguisorba officinalis as an inhibitor of DNA topoisomerases. Catalytic strand-passing a
Autor:
Yasuhiro Fukushima, Ibrahim D. Bori, Kuo Hsiung Lee, Li Sun, Barry Goz, Kenneth F. Bastow, Hiroshi Tatematsu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:1045-1050
Two colchicine derivatives gave dose-dependent cytocidal effects in human osteogenic sarcoma cells. Unlike colchicine, the analogues stimulated formation of intacellular protein-linked DNA breaks, they inhibited DNA topoisomerase II in vitro, and the
Autor:
Ibrahim D. Bori, David C. Muddiman, Daniel L. Comins, D. Keith Williams, Adam M. Hawkridge, Corey W. Meadows
Publikováno v:
Journal of the American Chemical Society. 130(7)
Hydrophobic tags, derived from iodoacetamide, were synthesized, characterized, and utilized to alkylate peptide E-76, a known inhibitor of coagulation factor VIIIa, and two other cysteine containing peptides. The electrospray response of each tagged