Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ibrahim Chehade"'
Autor:
L. Palanikumar, Laura Karpauskaite, Mohamed Al-Sayegh, Ibrahim Chehade, Maheen Alam, Sarah Hassan, Debabrata Maity, Liaqat Ali, Mona Kalmouni, Yamanappa Hunashal, Jemil Ahmed, Tatiana Houhou, Shake Karapetyan, Zackary Falls, Ram Samudrala, Renu Pasricha, Gennaro Esposito, Ahmed J. Afzal, Andrew D. Hamilton, Sunil Kumar, Mazin Magzoub
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-24 (2021)
Amyloid aggregation of mutant p53 contributes to its loss of tumor suppressor function and oncogenic gain-of-function. Here, the authors use a protein mimetic to abrogate mutant p53 aggregation and rescue p53 function, which inhibits cancer cell prol
Externí odkaz:
https://doaj.org/article/aabfbc8d47544f739652c54bd2eb3f1f
Autor:
Laura Karpauskaite, Ahmed J. Afzal, Ibrahim Chehade, Jemil Ahmed, Renu Pasricha, Mazin Magzoub, Andrew D. Hamilton, Debabrata Maity, Mona Kalmouni, Loganathan Palanikumar, Sunil Kumar, Maheen Alam, Tatiana Houhou, Gennaro Esposito, Zackary Falls, Shake Karapetyan, Yamanappa Hunashal, Ram Samudrala, Mohamed Al-Sayegh, Liaqat Ali, Sarah Hassan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-24 (2021)
Nature Communications
Nature Communications
Missense mutations in p53 are severely deleterious and occur in over 50% of all human cancers. The majority of these mutations are located in the inherently unstable DNA-binding domain (DBD), many of which destabilize the domain further and expose it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::914b9d23167b4db0a4609f8d776a3030
https://doaj.org/article/aabfbc8d47544f739652c54bd2eb3f1f
https://doaj.org/article/aabfbc8d47544f739652c54bd2eb3f1f
Autor:
Mazin Magzoub, Sarah Hassan, Maheen Alam, Yamanappa Hunashal, Gennaro Esposito, Mohamed Al-Sayegh, Ibrahim Chehade, Liaqat Ali, Zackary Falls, Andrew D. Hamilton, Renu Pasricha, Sunil Kumar, Laura Karpauskaite, Ahmed J. Afzal, Mona Kalmouni, Jemil Ahmed, Ram Samudrala, Debabrata Maity, Loganathan Palanikumar, Shake Karapetyan
Missense mutations in p53 are severely deleterious and occur in over 50% of all human cancers. The vast majority of these mutations are located in the inherently unstable DNA-binding domain (DBD), many of which destabilize the domain further and expo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fa961805711ad26790abd3b96f53b97
https://doi.org/10.1101/2020.08.10.243154
https://doi.org/10.1101/2020.08.10.243154
Autor:
Palanikumar Loganathan, Laura Karpauskaite, Mohamed Al-Sayegh, Ibrahim Chehade, Maheen Ali, Sarah Hassan, Debabrata Maity, Liaqat Ali, Mona Kalmouni, Tatiana Houhou, Gennaro Esposito, Ahmed J. Afzal, Andrew D. Hamilton, Sunil Kumar, Mazin Magzoub
Publikováno v:
Biophysical Journal. 121:300a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe04b24e5b092891b3c7e61f9e1fc2ce
https://doi.org/10.1016/j.bpj.2021.11.1253
https://doi.org/10.1016/j.bpj.2021.11.1253
Autor:
Zhihua An, Lu Zhang, Wael M. Rabeh, Daniel Carelli, Jamie Whelan, Joseph Koussa, Joel Bernstein, Ibrahim Chehade, Adrienne Chang, Merima Sabanovic
Publikováno v:
Journal of Applied Crystallography. 51:1474-1480
The research-driven laboratory experiment described herein has at its core the individual development of students, combining core subject matter with the opportunity to explore, in a research environment, areas outside of traditional curricula; howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b04074ebd1a58159d86dbf081b6ebf11
https://doi.org/10.1107/s1600576718009573
https://doi.org/10.1107/s1600576718009573
Autor:
Marios S. Katsiotis, Ibrahim Chehade, Christy Maksoudian, Mazin Magzoub, Saeed M. Alhassan, Vineeth Mukundan, Maria C. Vogel
Publikováno v:
Archives of Biochemistry and Biophysics. 613:31-42
Prion diseases are associated with conversion of cellular prion protein (PrPC) into an abnormally folded and infectious scrapie isoform (PrPSc). We previously showed that peptides derived from the unprocessed N-termini of mouse and bovine prion prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9772df2700750daaa612df5d3ebe969d
https://doi.org/10.1016/j.abb.2016.11.001
https://doi.org/10.1016/j.abb.2016.11.001
Autor:
Robert, Rutherford, Andrea, Lister, Thijs, Bosker, Tamzin, Blewett, Esteban, Gillio Meina, Ibrahim, Chehade, Thiviya, Kanagasabesan, Deborah, MacLatchy
Publikováno v:
General and comparative endocrinology. 289
The environmental estrogen 17α-ethinylestradiol (EE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5de08e3d1702c2744b4be0911bc6c057
https://pubmed.ncbi.nlm.nih.gov/31899193
https://pubmed.ncbi.nlm.nih.gov/31899193
Publikováno v:
Journal of the American Chemical Society. 139(47)
The conversion of the native random coil amyloid beta (Aβ) into amyloid fibers is thought to be a key event in the progression of Alzheimer's disease (AD). A significant body of evidence suggests that the highly dynamic Aβ oligomers are the main ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd493f93e2d96a29dc490f4042d98569
https://pubmed.ncbi.nlm.nih.gov/29058422
https://pubmed.ncbi.nlm.nih.gov/29058422