Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Ibrahim Alkanfari"'
1
Akademický článek
Bond strength and surface roughness assessment of novel antimicrobial polymeric coated dental cement
Autor: Ghada Naguib, Hisham Mously, Jumana Mazhar, Ibrahim Alkanfari, Abdulelah Binmahfooz, Mohammed Zahran, Mohamed T. Hamed
Publikováno v: Discover Nano, Vol 19, Iss 1, Pp 1-16 (2024)
Abstract Resin cement integrated with zein-incorporated magnesium oxide nanoparticles has previously been found to inhibit oral microbes and decrease bacterial biofilm. However, the bond strength and surface features of this biomaterial have yet to b
Externí odkaz: https://doaj.org/article/dd275acfc8cd4142be6f6d0a20d5d71a
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2
Akademický článek
Inhibition of Orai Channel Function Regulates Mas-Related G Protein-Coupled Receptor-Mediated Responses in Mast Cells
Autor: Shaswati Chaki, Ibrahim Alkanfari, Saptarshi Roy, Aetas Amponnawarat, Yvonne Hui, Carole A. Oskeritzian, Hydar Ali
Publikováno v: Frontiers in Immunology, Vol 12 (2022)
Mast cells (MCs) are tissue resident immune cells that play important roles in the pathogenesis of allergic disorders. These responses are mediated via the cross-linking of cell surface high affinity IgE receptor (FcϵRI) by antigen resulting in calc
Externí odkaz: https://doaj.org/article/4d508b276d3d4674871c7029501791e0
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3
Akademický článek
Identification of Gain and Loss of Function Missense Variants in MRGPRX2’s Transmembrane and Intracellular Domains for Mast Cell Activation by Substance P
Autor: Chalatip Chompunud Na Ayudhya, Saptarshi Roy, Ibrahim Alkanfari, Anirban Ganguly, Hydar Ali
Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 21, p 5247 (2019)
The neuropeptide substance P (SP) contributes to neurogenic inflammation through the activation of human mast cells via Mas-related G protein-coupled receptor-X2 (MRGPRX2). Using pertussis toxins and YM-254890, we demonstrated that SP induces Ca2+ mo
Externí odkaz: https://doaj.org/article/c8f6119456e748dabd9249d3c5e86e4d
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4
Akademický článek
Small-Molecule Host-Defense Peptide Mimetic Antibacterial and Antifungal Agents Activate Human and Mouse Mast Cells via Mas-Related GPCRs
Autor: Ibrahim Alkanfari, Katie B. Freeman, Saptarshi Roy, Tahsin Jahan, Richard W. Scott, Hydar Ali
Publikováno v: Cells, Vol 8, Iss 4, p 311 (2019)
Host-defense peptides (HDPs) have an important therapeutic potential against microbial infections but their metabolic instability and cellular cytotoxicity have limited their utility. To overcome these limitations, we utilized five small-molecule, no
Externí odkaz: https://doaj.org/article/63a64d548a7f4fe7a9f5b2c5cf7b6ab9
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5
Role of MrgprB2 in Rosacea-Like Inflammation in Mice: Modulation by β-Arrestin 2
Autor: Saptarshi Roy, Ibrahim Alkanfari, Shaswati Chaki, Hydar Ali
Publikováno v: Journal of Investigative Dermatology. 142:2988-2997.e3
Cathelicidin LL-37‒mediated activation of mast cells (MCs) has been implicated in the pathogenesis of rosacea, but the receptor involved and the mechanism of its activation and regulation remain unknown. We found that skin biopsies from patients wi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49def48d3fc0a702162cbee21d7e994c
https://doi.org/10.1016/j.jid.2022.05.005
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6
Small-Molecule Host-Defense Peptide Mimetic Antibacterial and Antifungal Agents Activate Human and Mouse Mast Cells via Mas-Related GPCRs
Autor: Richard W. Scott, Hydar Ali, Tahsin Jahan, Saptarshi Roy, Katie B. Freeman, Ibrahim Alkanfari
Publikováno v: Cells
Volume 8
Issue 4
Cells, Vol 8, Iss 4, p 311 (2019)
Host-defense peptides (HDPs) have an important therapeutic potential against microbial infections but their metabolic instability and cellular cytotoxicity have limited their utility. To overcome these limitations, we utilized five small-molecule, no
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a31f272cf3a7f004f1a1671337ffa67
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7
Naturally occurring Missense MRGPRX2 variants display Loss of Function Phenotype for Mast Cell Degranulation in response to Substance P, Hemokinin-1, Human β-defensin 3 and Icatibant
Autor: Hydar Ali, Ibrahim Alkanfari, Kshitij Gupta, Tahsin Jahan
Human mast cells (MCs) express a novel G protein–coupled receptor (GPCR) known as Mas-related GPCR X2 (MRGPRX2). Activation of this receptor by a diverse group of cationic ligands such as neuropeptides, host defense peptides, and Food and Drug Admi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64c1e87d56f12a7852a8256e8b33852c
https://europepmc.org/articles/PMC6039248/
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8
Identification of Gain and Loss of Function Missense Variants in MRGPRX2’s Transmembrane and Intracellular Domains for Mast Cell Activation by Substance P
Autor: Hydar Ali, Chalatip Chompunud Na Ayudhya, Ibrahim Alkanfari, Saptarshi Roy, Anirban Ganguly
Publikováno v: International Journal of Molecular Sciences
Volume 20
Issue 21
International Journal of Molecular Sciences, Vol 20, Iss 21, p 5247 (2019)
The neuropeptide substance P (SP) contributes to neurogenic inflammation through the activation of human mast cells via Mas-related G protein-coupled receptor-X2 (MRGPRX2). Using pertussis toxins and YM-254890, we demonstrated that SP induces Ca2+ mo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9475888097bde7bcb16ef9a582bac8cb
https://doi.org/10.3390/ijms20215247
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