Výsledky vyhledávání - "Ibrahim Al'Abri"

Akademický článek

Improving therapeutic protein secretion in the probiotic yeast Saccharomyces boulardii using a multifactorial engineering approach

Autor: Deniz Durmusoglu, Ibrahim Al’Abri, Zidan Li, Taufika Islam Williams, Leonard B. Collins, José L. Martínez, Nathan Crook

Publikováno v: Microbial Cell Factories, Vol 22, Iss 1, Pp 1-18 (2023)

Abstract The probiotic yeast Saccharomyces boulardii (Sb) is a promising chassis to deliver therapeutic proteins to the gut due to Sb’s innate therapeutic properties, resistance to phage and antibiotics, and high protein secretion capacity. To main

Externí odkaz: https://doaj.org/article/bec869ba4fae465585a62866ec5e5cf0

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Akademický článek

Engineered cell differentiation and sexual reproduction in probiotic and mating yeasts

Autor: Emil D. Jensen, Marcus Deichmann, Xin Ma, Rikke U. Vilandt, Giovanni Schiesaro, Marie B. Rojek, Bettina Lengger, Line Eliasson, Justin M. Vento, Deniz Durmusoglu, Sandie P. Hovmand, Ibrahim Al’Abri, Jie Zhang, Nathan Crook, Michael K. Jensen

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

G protein-coupled receptors (GPCRs) enable cells to sense environmental cues and are indispensable for coordinating vital processes including quorum sensing, proliferation, and sexual reproduction. Here the authors, using heterologous GPCR expression

Externí odkaz: https://doaj.org/article/47f9576f187340baa92bf1ba45054259

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Akademický článek

A Novel Method of Inducible Directed Evolution to Evolve Complex Phenotypes

Autor: Ibrahim Al'Abri, Zidan Li, Daniel Haller, Nathan Crook

Publikováno v: Bio-Protocol, Vol 12, Iss 20 (2022)

Directed evolution is a powerful technique for identifying beneficial mutations in defined DNA sequences with the goal of improving desired phenotypes. Recent methodological advances have made the evolution of short DNA sequences quick and easy. Howe

Externí odkaz: https://doaj.org/article/33530b0517da45ac9d79ba77ed1be414

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Improving Therapeutic Protein Secretion in the Probiotic YeastSaccharomyces boulardiiusing a Multifactorial Engineering Approach

Autor: Deniz Durmusoglu, Ibrahim Al’Abri, Taufika Islam Williams, Leonard B. Collins, José L. Martínez, Nathan Crook

The probiotic yeastSaccharomyces boulardii(Sb) is a promising chassis to deliver therapeutic proteins to the gut due toSb’s innate therapeutic properties, resistance to phage and antibiotics, and high protein secretion capacity. To maintain therape

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a84fe29e8f3b5cbcdd87a7c11bc8f4b8
https://doi.org/10.1101/2022.12.30.522352