Building on the clinical applicability of ctDNA analysis in non-metastatic pancreatic ductal adenocarcinoma

Autor: Ibone Labiano, Ana E. Huerta, Maria Alsina, Hugo Arasanz, Natalia Castro, Saioa Mendaza, Arturo Lecumberri, Iranzu Gonzalez-Borja, David Guerrero-Setas, Ana Patiño-Garcia, Gorka Alkorta-Aranburu, Irene Hernández-Garcia, Virginia Arrazubi, Elena Mata, David Gomez, Antonio Viudez, Ruth Vera

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Abstract Pancreatic ductal adenocarcinoma represents one of the solid tumors showing the worst prognosis worldwide, with a high recurrence rate after adjuvant or neoadjuvant therapy. Circulating tumor DNA analysis raised as a promising non-invasive t

Externí odkaz: https://doaj.org/article/f92620ce655e4f569495af68107a7fe1

Cholangiocarcinoma progression depends on the uptake and metabolization of extracellular lipids

Autor: Mikel Ruiz de Gauna, Francesca Biancaniello, Francisco González‐Romero, Pedro M. Rodrigues, Ainhoa Lapitz, Beatriz Gómez‐Santos, Paula Olaizola, Sabina Di Matteo, Igor Aurrekoetxea, Ibone Labiano, Ane Nieva‐Zuluaga, Asier Benito‐Vicente, María J. Perugorria, Maider Apodaka‐Biguri, Nuno A. Paiva, Diego Sáenz de Urturi, Xabier Buqué, Igotz Delgado, César Martín, Mikel Azkargorta, Felix Elortza, Diego F. Calvisi, Jesper B. Andersen, Domenico Alvaro, Vincenzo Cardinale, Luis Bujanda, Jesús M. Banales, Patricia Aspichueta

Publikováno v: Ruiz de Gauna, M, Biancaniello, F, González-Romero, F, Rodrigues, P M, Lapitz, A, Gómez-Santos, B, Olaizola, P, Di Matteo, S, Aurrekoetxea, I, Labiano, I, Nieva-Zuluaga, A, Benito-Vicente, A, Perugorria, M J, Apodaka-Biguri, M, Paiva, N A, Sáenz de Urturi, D, Buqué, X, Delgado, I, Martín, C, Azkargorta, M, Elortza, F, Calvisi, D F, Andersen, J B, Alvaro, D, Cardinale, V, Bujanda, L, Banales, JM & Aspichueta, P 2022, ' Cholangiocarcinoma progression depends on the uptake and metabolization of extracellular lipids ', Hepatology, vol. 76, no. 6, pp. 1617-1633 . https://doi.org/10.1002/hep.32344

[Background and Aims] Cholangiocarcinoma (CCA) includes a heterogeneous group of biliary cancers with a dismal prognosis. We investigated if lipid metabolism is disrupted in CCA and its role in tumor proliferation.
[Approach and Results] The in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78325d0133d0e5293fd2e7b3e6a39a25
http://hdl.handle.net/10261/304495

State of the Art: ctDNA in Upper Gastrointestinal Malignancies

Autor: Ibone Labiano, Ana Elsa Huerta, Virginia Arrazubi, Irene Hernandez-Garcia, Elena Mata, David Gomez, Hugo Arasanz, Ruth Vera, Maria Alsina

Publikováno v: Cancers. 15:1379

Circulating tumor DNA (ctDNA) has emerged as a promising non-invasive source to characterize genetic alterations related to the tumor. Upper gastrointestinal cancers, including gastroesophageal adenocarcinoma (GEC), biliary tract cancer (BTC) and pan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f7192770dc6127afbcbf88e3bd3e4ef
https://doi.org/10.3390/cancers15051379

TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms

Autor: Gernot Schabbauer, Alona Agirre-Lizaso, Ana Landa, Pedro Rodrigues, Sylvia Knapp, Omar Sharif, Patricia Munoz-Garrido, Colm J O'Rourke, Mikel Azkargorta, Patricia Aspichueta, Jesper B. Andersen, Adelaida La Casta, Derek A. Mann, Marco Y W Zaki, Aitor Esparza-Baquer, Ekaterina Zhuravleva, Raul Jimenez-Agüero, Elizabeth Hijona, Fiona Oakley, Felix Elortza, Jesus M. Banales, Ibone Labiano, Luis Bujanda, Maria J. Perugorria, Andrea Vogel, Ioana Riaño

Publikováno v: Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
Addi. Archivo Digital para la Docencia y la Investigación
instname
Esparza-Baquer, A, Labiano, I, Sharif, O, Agirre-Lizaso, A, Oakley, F, Rodrigues, P M, Zhuravleva, E, O'Rourke, C J, Hijona, E, Jimenez-Agüero, R, Riaño, I, Landa, A, La Casta, A, Zaki, M Y W, Munoz-Garrido, P, Azkargorta, M, Elortza, F, Vogel, A, Schabbauer, G, Aspichueta, P, Andersen, J B, Knapp, S, Mann, D A, Bujanda, L, Banales, J M & Perugorria, M J 2020, ' TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms ', Gut, vol. 70, no. 7 . https://doi.org/10.1136/gutjnl-2019-319227

[EN] Objective Hepatocellular carcinoma (HCC) is a prevalent and aggressive cancer usually arising on a background of chronic liver injury involving inflammatory and hepatic regenerative processes. The triggering receptor expressed on myeloid cells 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5101dbc9d21276c380d697790fd43d3c
http://hdl.handle.net/10810/52822

Wnt–β-catenin signalling in liver development, health and disease

Autor: Jesus M. Banales, Ibone Labiano, Marco Marzioni, Maria J. Perugorria, Paula Olaizola, Luis Bujanda, Jose J.G. Marin, Aitor Esparza-Baquer

Publikováno v: Nature Reviews Gastroenterology & Hepatology. 16:121-136

The canonical Wnt–β-catenin pathway is a complex, evolutionarily conserved signalling mechanism that regulates fundamental physiological and pathological processes. Wnt–β-catenin signalling tightly controls embryogenesis, including hepatobiliar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c2517286dcbefd1b96384a2b9b30590
https://doi.org/10.1038/s41575-018-0075-9