Leukemia Inhibitory Factor (LIF) Overexpression Increases the Angiogenic Potential of Bone Marrow Mesenchymal Stem/Stromal Cells

Autor: Girlaine Café Santos, Daniela Nascimento Silva, Vitor Fortuna, Brysa Mariana Silveira, Iasmim Diniz Orge, Thaís Alves de Santana, Gabriela Louise Sampaio, Bruno Diaz Paredes, Ricardo Ribeiro-dos-Santos, Milena Botelho Pereira Soares

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

Mesenchymal stem/stromal cells (MSCs) have the ability to secrete bioactive molecules, exerting multiple biological effects, such as tissue regeneration, reduction of inflammation, and neovascularization. The therapeutic potential of MSCs can be incr

Externí odkaz: https://doaj.org/article/7d1403c16a0a4e2887f386a06ff320b0

Betulinic Acid Derivative BA5, Attenuates Inflammation and Fibrosis in Experimental Chronic Chagas Disease Cardiomyopathy by Inducing IL-10 and M2 Polarization

Autor: Cássio Santana Meira, Emanuelle De Souza Santos, Renan Fernandes do Espírito Santo, Juliana Fraga Vasconcelos, Iasmim Diniz Orge, Carolina Kymie Vasques Nonaka, Breno Cardim Barreto, Alex Cleber Improta Caria, Daniela Nascimento Silva, José Maria Barbosa-Filho, Simone Garcia Macambira, Diogo Rodrigo Magalhães Moreira, Milena Botelho Pereira Soares

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Chronic Chagas disease cardiomyopathy (CCC) is a major cause of heart disease in Latin America and treatment for this condition is unsatisfactory. Here we investigated the effects of BA5, an amide semi-synthetic derivative betulinic acid, in a model

Externí odkaz: https://doaj.org/article/c949d552c4094e2cbfeb65aa9371f932

Engineering injectable vascularized tissues from the bottom-up: Dynamics of in-gel extra-spheroid dermal tissue assembly

Autor: Iasmim Diniz Orge, Mariana I. Neves, Daniel T. O. Carvalho, Ana Luísa Torres, Aureliana Sousa, Cristina C. Barrias, Sílvia J. Bidarra, Tália Feijão

Publikováno v: Biomaterials. 279

Modular tissue engineering approaches open up exciting perspectives for the biofabrication of vascularized tissues from the bottom-up, using micro-sized units such as spheroids as building blocks. While several techniques for 3D spheroid formation fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800aa498419a069bad9171fdfda3c54e
https://pubmed.ncbi.nlm.nih.gov/34736148

Genetic Engineering as a Strategy to Improve the Therapeutic Efficacy of Mesenchymal Stem/Stromal Cells in Regenerative Medicine

Autor: Thaís Alves de Santana, Massimo Pinelli, Giulia Grisendi, Juliana Fonseca Albuquerque, Milena Botelho Pereira Soares, Girlaine Café Santos, Patrícia Kauanna Fonseca Damasceno, Massimo Dominici, Daniela Nascimento Silva, Ricardo Ribeiro dos Santos, Iasmim Diniz Orge, Giulia Golinelli

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Frontiers in Cell and Developmental Biology

Mesenchymal stem/stromal cells (MSCs) have been widely studied in the field of regenerative medicine for applications in the treatment of several disease settings. The therapeutic potential of MSCs has been evaluated in studies in vitro and in vivo,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c59c7d71033aa63f10861abf8821f82
https://doi.org/10.3389/fcell.2020.00737

Phenotype instability of hepatocyte-like cells produced by direct reprogramming of mesenchymal stromal cells

Autor: Patrícia Kauanna Fonseca Damasceno, Judah Leão Barouh, Milena Botelho Pereira Soares, Kyan James Allahdadi, Gabriela Louise de Almeida Sampaio, Iasmim Diniz Orge, Stuart J. Forbes, Erik Aranha Rossi, Bruno Solano de Freitas Souza, Rejane Hughes Carvalho, Bruno Diaz Paredes, Daniela Nascimento Silva, Victoria L. Gadd, Ian Smith

Publikováno v: Orge, I D, Gadd, V, Barouh, J L, Rossi, E A, Carvalho, R H, Smith, I, Allahdadi, K J, Paredes, B D, Silva, D N, Damasceno, P K F, Sampaio, G L, Forbes, S, Soares, M B P & de Freitas Souza, B S 2020, ' Phenotype instability of hepatocyte-like cells produced by direct reprogramming of mesenchymal stromal cells ', Stem Cell Research and Therapy . https://doi.org/10.1186/s13287-020-01665-z
Stem Cell Research & Therapy
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-15 (2020)

Background Hepatocyte-like cells (iHEPs) generated by transcription factor-mediated direct reprogramming of somatic cells have been studied as potential cell sources for the development of novel therapies targeting liver diseases. The mechanisms invo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec1081173483f289a100644a6b454357
https://doi.org/10.1186/s13287-020-01665-z