Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Iart Luca, Shytaj"'
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102253- (2023)
Summary: Integrated HIV-1 DNA persists in cells of people living with HIV during antiretroviral treatment, but its quantification is hindered by its rarity. Here, we present an optimized protocol to evaluate “shock and kill” therapeutic strategie
Externí odkaz:
https://doaj.org/article/f8be3c6834fe4ae09552feab9061ada7
Autor:
Mona Rheinberger, Ana Luisa Costa, Martin Kampmann, Dunja Glavas, Iart Luca Shytaj, Sheetal Sreeram, Carlotta Penzo, Nadine Tibroni, Yoelvis Garcia-Mesa, Konstantin Leskov, Oliver T. Fackler, Kristian Vlahovicek, Jonathan Karn, Bojana Lucic, Carl Herrmann, Marina Lusic
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112110- (2023)
Summary: HIV-1 encounters the hierarchically organized host chromatin to stably integrate and persist in anatomically distinct latent reservoirs. The contribution of genome organization in HIV-1 infection has been largely understudied across differen
Externí odkaz:
https://doaj.org/article/6d1fc39be46e44d28da6d139b84c5bcf
Autor:
Marcella Vassão de Almeida Baptista, Laís Teodoro da Silva, Sadia Samer, Telma Miyuki Oshiro, Iart Luca Shytaj, Leila B. Giron, Nathalia Mantovani Pena, Nicolly Cruz, Gisele Cristina Gosuen, Paulo Roberto Abrão Ferreira, Edécio Cunha-Neto, Juliana Galinskas, Danilo Dias, Maria Cecilia Araripe Sucupira, Cesar de Almeida-Neto, Reinaldo Salomão, Alberto José da Silva Duarte, Luís Mário Janini, James R. Hunter, Andrea Savarino, Maria Aparecida Juliano, Ricardo Sobhie Diaz
Publikováno v:
AIDS Research and Therapy, Vol 19, Iss 1, Pp 1-15 (2022)
Abstract Background We developed a personalized Monocyte-Derived Dendritic-cell Therapy (MDDCT) for HIV-infected individuals on suppressive antiretroviral treatment and evaluated HIV-specific T-cell responses. Methods PBMCs were obtained from 10 HIV+
Externí odkaz:
https://doaj.org/article/3c388043e304443cb84d389ca26a43d2
Autor:
Noha Samir Taibe, Maimona A. Kord, Mohamed Ahmed Badawy, Iart Luca Shytaj, Mahmoud M. Elhefnawi
Publikováno v:
Therapeutic Advances in Respiratory Disease, Vol 16 (2022)
On 30 January 2020, the World Health Organization (WHO) declared the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic a public health emergency of international concern. The viral outbreak led in turn to an exponential grow
Externí odkaz:
https://doaj.org/article/5fe3309708e8475b98442ee6e3abba2a
Autor:
Iart Luca Shytaj, Mohamed Fares, Lara Gallucci, Bojana Lucic, Mahmoud M. Tolba, Liv Zimmermann, Julia M. Adler, Na Xing, Judith Bushe, Achim D. Gruber, Ina Ambiel, Ahmed Taha Ayoub, Mirko Cortese, Christopher J. Neufeldt, Bettina Stolp, Mohamed Hossam Sobhy, Moustafa Fathy, Min Zhao, Vibor Laketa, Ricardo Sobhie Diaz, Richard E. Sutton, Petr Chlanda, Steeve Boulant, Ralf Bartenschlager, Megan L. Stanifer, Oliver T. Fackler, Jakob Trimpert, Andrea Savarino, Marina Lusic
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Combinations of direct-acting antivirals are needed to minimize drug resistance mutations and stably suppress replication of RNA viruses. Currently, there are limited therapeutic options against the severe acute respiratory syndrome coronavi
Externí odkaz:
https://doaj.org/article/30bf4bc23be645f7a9bdfa7dd16e08e5
Autor:
Iart Luca Shytaj, Francesco Andrea Procopio, Mohammad Tarek, Irene Carlon‐Andres, Hsin‐Yao Tang, Aaron R Goldman, MohamedHusen Munshi, Virender Kumar Pal, Mattia Forcato, Sheetal Sreeram, Konstantin Leskov, Fengchun Ye, Bojana Lucic, Nicolly Cruz, Lishomwa C Ndhlovu, Silvio Bicciato, Sergi Padilla‐Parra, Ricardo Sobhie Diaz, Amit Singh, Marina Lusic, Jonathan Karn, David Alvarez‐Carbonell, Andrea Savarino
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 8, Pp n/a-n/a (2021)
Abstract HIV‐1 infects lymphoid and myeloid cells, which can harbor a latent proviral reservoir responsible for maintaining lifelong infection. Glycolytic metabolism has been identified as a determinant of susceptibility to HIV‐1 infection, but i
Externí odkaz:
https://doaj.org/article/c1e843aa09bd42f190c50b143e7746de
Publikováno v:
Genetics & Applications, Vol 2, Iss 2, Pp 51-56 (2018)
Topoisomerase-I is required for DNA replication. It acts by preventing torsional stress caused by DNA winding during replication fork progression. Topoisomerase-I inhibitors are widely used in many cancer therapies, in light of their anti-proliferati
Externí odkaz:
https://doaj.org/article/67f5776b16544d11930f90d0011e03bd
Autor:
Mona Rheinberger, Ana Luisa Costa, Martin Kampmann, Dunja Glavas, Iart Luca Shytaj, Carlotta Penzo, Nadine Tibroni, Oliver T. Fackler, Kristian Vlahovicek, Bojana Lucic, Carl Herrmann, Marina Lusic
HIV-1 persists in anatomically distinct cellular and tissue reservoirs as a stably integrated provirus that is a major barrier to HIV-1 cure. Proviral insertions are largely characterized in blood cells, while HIV-1 integration patterns remain unexpl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63bd07707ae8ab4c6cd43f1b746db963
https://doi.org/10.1101/2022.02.14.480322
https://doi.org/10.1101/2022.02.14.480322
Autor:
Mona Rheinberger, Ana Luisa Costa, Martin Kampmann Kampmann, Dunja Glavas, Iart Luca Shytaj, Carlotta Penzo, Nadine Tibroni, Oliver Fackler, Kristian Vlahovicek, Bojana Lucic, Carl Herrmann, Marina Lusic
Publikováno v:
SSRN Electronic Journal.
Autor:
Marina Lusic, Steeve Boulant, Iart Luca Shytaj, Christopher J. Neufeldt, Petr Chlanda, Mirko Cortese, Ralf Bartenschlager, Oliver T. Fackler, Ahmed T. Ayoub, Bojana Lucic, Mahmoud M. Tolba, Lara Gallucci, Andrea Savarino, Liv Zimmermann, Vibor Laketa, Mohamed Fares, Megan L. Stanifer
Combinations of direct-acting antivirals are needed to minimize drug-resistance mutations and stably suppress replication of RNA viruses. Currently, there are limited therapeutic options against the Severe Acute Respiratory Syndrome Corona Virus 2 (S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89a318db23beae4fa9314b71a9390ce0
https://doi.org/10.1101/2021.03.09.434219
https://doi.org/10.1101/2021.03.09.434219