Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Iaroslava Kos"'
Autor:
Alessandra da Silva Dantas, Alison Day, Mélanie Ikeh, Iaroslava Kos, Beatrice Achan, Janet Quinn
Publikováno v:
Biomolecules, Vol 5, Iss 1, Pp 142-165 (2015)
Candida albicans is a major fungal pathogen of humans, causing approximately 400,000 life-threatening systemic infections world-wide each year in severely immunocompromised patients. An important fungicidal mechanism employed by innate immune cells i
Externí odkaz:
https://doaj.org/article/f36108456d2d408785d749729a937c1c
Autor:
Iaroslava Kos, Miranda J. Patterson, Sadri Znaidi, Despoina Kaloriti, Alessandra da Silva Dantas, Carmen M. Herrero-de-Dios, Christophe d’Enfert, Alistair J. P. Brown, Janet Quinn
Publikováno v:
mBio, Vol 7, Iss 2 (2016)
ABSTRACT Following phagocytosis, microbes are exposed to an array of antimicrobial weapons that include reactive oxygen species (ROS) and cationic fluxes. This is significant as combinations of oxidative and cationic stresses are much more potent tha
Externí odkaz:
https://doaj.org/article/22d63d835a5c45e88d190bf74bb3265c
Autor:
Léa El Khoury, Zhifeng Jing, Alberto Cuzzolin, Alessandro Deplano, Daniele Loco, Boris Sattarov, Florent Hédin, Sebastian Wendeborn, Chris Ho, Dina El Ahdab, Theo Jaffrelot Inizan, Mattia Sturlese, Alice Sosic, Martina Volpiana, Angela Lugato, Marco Barone, Barbara Gatto, Maria Ludovica Macchia, Massimo Bellanda, Roberto Battistutta, Cristiano Salata, Ivan Kondratov, Rustam Iminov, Andrii Khairulin, Yaroslav Mykhalonok, Anton Pochepko, Volodymyr Chashka-Ratushnyi, Iaroslava Kos, Stefano Moro, Matthieu Montes, Pengyu Ren, Jay W. Ponder, Louis Lagardère, Jean-Philip Piquemal, Davide Sabbadin
Publikováno v:
Chemical Science
Chemical Science, 2022, ⟨10.1039/D1SC05892D⟩
Chemical Science, 2022, ⟨10.1039/D1SC05892D⟩
We report a fast-track computationally-driven discovery of new SARS-CoV2 Main Protease (Mpro) inhibitors whose potency range from mM for initial non-covalent ligands to high nM for the final covalent compound (IC50=830 +/- 50 nM). The project extensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7fb3c770ad5b156560e839423dea37d
https://hal.science/hal-03361062
https://hal.science/hal-03361062
Autor:
Léa, El Khoury, Zhifeng, Jing, Alberto, Cuzzolin, Alessandro, Deplano, Daniele, Loco, Boris, Sattarov, Florent, Hédin, Sebastian, Wendeborn, Chris, Ho, Dina, El Ahdab, Theo, Jaffrelot Inizan, Mattia, Sturlese, Alice, Sosic, Martina, Volpiana, Angela, Lugato, Marco, Barone, Barbara, Gatto, Maria Ludovica, Macchia, Massimo, Bellanda, Roberto, Battistutta, Cristiano, Salata, Ivan, Kondratov, Rustam, Iminov, Andrii, Khairulin, Yaroslav, Mykhalonok, Anton, Pochepko, Volodymyr, Chashka-Ratushnyi, Iaroslava, Kos, Stefano, Moro, Matthieu, Montes, Pengyu, Ren, Jay W, Ponder, Louis, Lagardère, Jean-Philip, Piquemal, Davide, Sabbadin
Publikováno v:
Chemical science. 13(13)
We report a fast-track computationally driven discovery of new SARS-CoV-2 main protease (M