1-Ethyl-2-phenyl-3-[2-(trimethylsilyl)ethynyl]-1H-indole

Autor: Iaroslav Baglai, Valérie Maraval, Carine Duhayon, Remi Chauvin

Publikováno v: Acta Crystallographica Section E, Vol 69, Iss 6, Pp o921-o922 (2013)

The title compound, C21H23NSi, was synthesized by Sonogashira-type reaction of 1-ethyl-3-iodo-2-phenyl-1H-indole with trimethylsilylacetylene. The indole ring system is nearly planar [maximum atomic deviation = 0.0244 (15) Å] and is oriented at a di

Externí odkaz: https://doaj.org/article/f4cb56ba7e1947bd96781c32ac27064b

Chiral Amplification through the Interplay of Racemizing Conditions and Asymmetric Crystal Growth

Autor: Sjoerd W. van Dongen, Imane Ahlal, Michel Leeman, Bernard Kaptein, Richard M. Kellogg, Iaroslav Baglai, Willem L. Noorduin

Publikováno v: Journal of the American Chemical Society.

Amplification of enantiomeric excesses (ee) is routinely observed during chiral crystallization of conglomerate crystals for which the enantiomers undergo racemization in solution. Although routes comprising a combination of crystal growth and dissol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd2b04c2b1afedcd8e244d96d786d5a
https://pubmed.ncbi.nlm.nih.gov/36534614

Counteracting Enantiospecific Behavior of Tailor-Made Additives During Chiral Symmetry Breaking: Growth Inhibition versus Solid-Solution Formation

Autor: Richard M. Kellogg, Sjoerd W. van Dongen, Iaroslav Baglai, Willem L. Noorduin, Bernard Kaptein, Michel Leeman

Publikováno v: Israel journal of chemistry, 61(9-10), 645-649. Wiley-Blackwell

All biological systems are composed of molecules of a single chirality. Although many different scenarios can lead to chiral symmetry breaking, the transmission of the absolute configuration of one compound to another one remains challenging. We here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a63417acab4043f4a042207195484eb
https://dare.uva.nl/personal/pure/en/publications/counteracting-enantiospecific-behavior-of-tailormade-additives-during-chiral-symmetry-breaking-growth-inhibition-versus-solidsolution-formation(645e18d7-e7e0-4c12-a2cb-62a995654987).html

Combining Incompatible Processes for Deracemization of a Praziquantel Derivative under Flow Conditions

Autor: Michel Leeman, Iaroslav Baglai, Joop H. ter Horst, Willem L. Noorduin, Giulio Valenti, Bernard Kaptein, Richard M. Kellogg, Paul Tinnemans

Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie, International Edition, 60(10), 5279-5282. John Wiley and Sons Ltd
Angewandte Chemie. International Edition, 60, 5279-5282
Angewandte Chemie. International Edition, 60, 10, pp. 5279-5282
Angewandte Chemie, 133(10), 5339-5342. John Wiley and Sons Ltd

An efficient deracemization method for conversion of the racemate to the desirable (R)-enantiomer of Praziquantel has been developed by coupling incompatible racemization and crystallization processes. By a library approach, a derivative that crystal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620205bed4f121713b080dafc5605237

A chiral switch: balancing between equilibrium and non-equilibrium states

Autor: Bernard Kaptein, Iaroslav Baglai, Richard M. Kellogg, Michel Leeman, Willem L. Noorduin

Publikováno v: Chemical communications (Cambridge, England). 55(48)

Herein we introduce a “chiral switch” – a sequence of operations that alternate between equilibrium and non-equilibrium conditions to switch the absolute configuration of a chiral center. The generality and practical potential of the technique

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4737313607e252c73e62f24668804a91
https://pubmed.ncbi.nlm.nih.gov/31139788