The Emerging Role of Complement Lectin Pathway in Trypanosomatids: Molecular Bases in Activation, Genetic Deficiencies, Susceptibility to Infection, and Complement System-Based Therapeutics

Autor: Ingrid Evans-Osses, Iara de Messias-Reason, Marcel I. Ramirez

Publikováno v: The Scientific World Journal, Vol 2013 (2013)

The innate immune system is evolutionary and ancient and is the pivotal line of the host defense system to protect against invading pathogens and abnormal self-derived components. Cellular and molecular components are involved in recognition and effe

Externí odkaz: https://doaj.org/article/006bb20e351948cdabe45046184c847d

Clinical and epidemiological aspects of chronic Chagas disease from Southern Brazil

Autor: Eduardo Nunes Marques, Iara de Messias-Reason, Ricardo Castillo-Neyra, Marcia Holsbach Beltrame, Cesar Maistro Guimarães, Thaisa Lucas Sandri, Robert H. Gilman, Kárita Cláudia Freitas Lidani, Fabiana Antunes Andrade

Publikováno v: Revista da Sociedade Brasileira de Medicina Tropical
Revista da Sociedade Brasileira de Medicina Tropical, Volume: 53, Article number: e20200225, Published: 21 OCT 2020
Revista da Sociedade Brasileira de Medicina Tropical, Vol 53 (2020)
Revista da Sociedade Brasileira de Medicina Tropical v.53 2020
Sociedade Brasileira de Medicina Tropical (SBMT)
instacron:SBMT

INTRODUCTION: Patients with Chagas disease (CD), caused by Trypanosoma cruzi, present a higher risk of developing other chronic diseases, which may contribute to CD severity. Since CD is underreported in the southern state of Paraná, Brazil, we aime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ace282cd363dcbb930220984a0d124
https://pubmed.ncbi.nlm.nih.gov/33111908

Differential ability to resist to complement lysis and invade host cells mediated by MBL in R4 and 860 strains ofTrypanosoma cruzi

Autor: Andres Mojoli, Wanderson D. DaRocha, Marcel I. Ramirez, Iara de Messias-Reason, Ingrid Evans-Osses, Denise Endo da Costa, Marcia Holsbach Beltrame, Thirumalaisamy P. Velavan

Publikováno v: FEBS Letters. 588:956-961

To produce an infection Trypanosoma cruzi must evade lysis by the complement system. During early stages of infection, the lectin pathway plays an important role in host defense and can be activated by binding of mannan-binding lectin (MBL) to carboh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1474a469c369dc11945243fcce7bf76b
https://doi.org/10.1016/j.febslet.2014.01.054

Soroepidemiologia da hepatite B e C em índios Kaingang do Sul do Brasil Seroepidemiology of hepatitis B and C in Kaingang Indians in the South of Brazil

Autor: Aline Ferreira, Daniel Greca, Ery Tavares, Yatiyo Moriya, Florise Spelling, Maristela Boeira, Sidneis dos Santos, Iara de Messias-Reason

Publikováno v: Revista Panamericana de Salud Pública, Vol 20, Iss 4, Pp 230-235 (2006)

OBJETIVO: Investigar a prevalência de infecção pelo vírus da hepatite B e C na população indígena Kaingang da reserva de Mangueirinha, no Estado do Paraná, Brasil. MÉTODO: A presença dos marcadores sorológicos anti-HBc, anti-HBs, AgHBs e a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::9d52fe043a8c98a151bc7515d029a7f7
http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892006000900003

Mechanisms of complement lectin pathway activation and resistance by trypanosomatid parasites

Autor: Luregn J. Schlapbach, Iara de Messias-Reason, Igor Cestari, Ingrid Evans-Osses, Marcel I. Ramirez

Publikováno v: Molecular immunology. 53(4)

Studies in the past decade have demonstrated a crucial role for the complement lectin pathway in host defence against protozoan microbes. Recognition of pathogen surface molecules by mannan-binding lectin and ficolins revealed new mechanisms of innat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e91fd58a22856d030ca6ee06a9edb5
https://pubmed.ncbi.nlm.nih.gov/23063472