Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Iana Serafimova"'
Autor:
Bruce Fahr, Yafan Lu, Iana Serafimova, David E. Stockett, Phuongly Pham, Junfa Fan, Ingrid C. Choong, Duncan Walker, Ute Hoch, Sravanthi Cheeti, Erica Chan, Michelle R. Arkin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5763-5765
The identification of a selective CDK2, 7, 9 inhibitor 4 with improved permeability is described. Compound 4 exhibits comparable CDK selectivity profile to SNS-032, but shows improved permeability and higher bioavailability in mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::303937ba3989812bb0cb962ae59184ed
https://doi.org/10.1016/j.bmcl.2008.09.073
https://doi.org/10.1016/j.bmcl.2008.09.073
Autor:
Bruce Fahr, Junfa Fan, Duncan Walker, Sravanthi Cheeti, Ute Hoch, Erica Chan, Phuongly Pham, Ingrid C. Choong, Yafan Lu, Iana Serafimova, David E. Stockett
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(23)
Modifications of the isonipecotic acid fragment of SNS-032 results in analogs which are more permeable and lower effluxed than SNS-032. The enantiomerically pure synthesis and the in vivo profile of analog 20 is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da9bc8309e1c73e79a6b57e6f045ab0
https://pubmed.ncbi.nlm.nih.gov/18926699
https://pubmed.ncbi.nlm.nih.gov/18926699