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Akademický článek

PD-L1 protects tumor-associated dendritic cells from ferroptosis during immunogenic chemotherapy

Autor: Kaimin Xiao, Silin Zhang, Qi Peng, Yuxia Du, Xiyue Yao, Ian-Ian Ng, Haidong Tang

Publikováno v: Cell Reports, Vol 43, Iss 11, Pp 114868- (2024)

Summary: Dendritic cells (DCs) express high levels of PD-L1 in the tumor microenvironment. However, the physiological functions of PD-L1 on DCs remain incompletely understood. Here, we explored the roles of PD-L1 signaling during immunogenic chemothe

Externí odkaz: https://doaj.org/article/7f23e64397924976a5f1d9b4d40e04ef

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Akademický článek

Network-based screening identifies sitagliptin as an antitumor drug targeting dendritic cells

Autor: Zheng Huang, Jiaqi Zhang, Qi Peng, Lui Ng, Ian-Ian Ng, Tingzhong Tian, Kaimin Xiao, Xiyue Yao, Jianyang Zeng, Haidong Tang

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 3 (2024)

Background Dendritic cell (DC)-mediated antigen presentation is essential for the priming and activation of tumor-specific T cells. However, few drugs that specifically manipulate DC functions are available. The identification of drugs targeting DC h

Externí odkaz: https://doaj.org/article/5f3dfc3145cf4cb3b476a733d713c653

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Akademický článek

Unraveling the molecular mechanism of collagen flexibility during physiological warmup using molecular dynamics simulation and machine learning

Autor: Wei-Han Hui, Pei-Hsin Chiu, Ian-Ian Ng, Shu-Wei Chang, Chia-Ching Chou, Hsiang-Ho Chen

Publikováno v: Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 1630-1638 (2023)

Physiological warmup plays an important role in reducing the injury risk in different sports. In response to the associated temperature increase, the muscle and tendon soften and become easily stretched. In this study, we focused on type I collagen,

Externí odkaz: https://doaj.org/article/a292012fcf7d4417a944d27af32b1073

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