Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ian de Belle"'
Publikováno v:
BioTechniques, Vol 29, Iss 1, Pp 162-169 (2000)
A methodology is described that allows the in vivo trapping of transcription factors to their target regulatory elements in multiple genes simultaneously. Cross-linking using formaldehyde is the first of several steps to isolate, purify, clone and ch
Externí odkaz:
https://doaj.org/article/4825ae528c2c4dd1a12b0f9c14707d91
Publikováno v:
FEBS Letters. 583:2165-2170
The TOE1 gene was discovered as a target of the Egr1 transcription factor that participates in cell growth regulation through the upregulation of p21 and a cell cycle delay at the G2/M phase. We report here that TOE1 is able to bind to the p53 tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52bc189f0418804ba09e571dd1d0c6a8
https://doi.org/10.1016/j.febslet.2009.06.004
https://doi.org/10.1016/j.febslet.2009.06.004
Autor:
Ian de Belle, Sabina Sperandio, Lynda Robitaille, Jessyka Fortin, Jacques Corbeil, Roman Sasik
Publikováno v:
Molecular Carcinogenesis. 48:38-44
Using oligonucleotide expression microarrays we have examined the modulation of gene expression in the DU145 prostate cancer cell line. Our findings confirm that the Egr1 transcription factor is rapidly and transiently upregulated by hypoxia. Further
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75e64087d947bd839100a4ce7d6dd5b
https://doi.org/10.1002/mc.20454
https://doi.org/10.1002/mc.20454
Autor:
Michel J. Tremblay, Ana Gargaun, Ian de Belle, Miguel A. Cabrita, Maxim V. Berezovski, Corinne Barat, Sabina Sperandio
Publikováno v:
Proceedings of the National Academy of Sciences. 112
Target of Egr1 (TOE1) is a nuclear protein localized primarily in nucleoli and Cajal bodies that was identified as a downstream target of the immediate early gene Egr1. TOE1 displays a functional deadenylation domain and has been shown to participate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d46487c90e17f89fee75e4f444e3d70
https://doi.org/10.1073/pnas.1500857112
https://doi.org/10.1073/pnas.1500857112
Autor:
Jun Hayakawa, Ann H. Cho, Dan Mercola, Fred Long, John Welsh, Eileen D. Adamson, Michael McClelland, Yipeng Wang, Qiuju Yu, Ian de Belle, Shalu Mittal, Gaelle Rondeau
Publikováno v:
Annals of the New York Academy of Sciences. 1058:162-185
DNA microarrays of promoter sequences have been developed in order to identify the profile of genes bound and activated by DNA regulatory proteins such as the transcription factors c-Jun and ATF2 as well as DNA-modifying methylases. The arrays contai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dfc1f6550dc3a3d2d154246f037ce5c
https://doi.org/10.1196/annals.1359.024
https://doi.org/10.1196/annals.1359.024
Autor:
Ian de Belle, Rama Khokha, Katrina L Watson, Carlo V. Hojilla, Geoffrey A. Wood, Jimmie E. Fata, Roger A. Moorehead, Eileen D. Adamson, Dylan R. Edwards
Publikováno v:
Journal of Biological Chemistry. 278:50422-50427
The tumor suppressor PTEN is altered in many cancers, including breast cancer, but only a handful of factors are known to control its expression. PTEN plays a vital role in cell survival and proliferation by regulating Akt phosphorylation, a key comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::521a5cbb2fe9bb071bd0aa12934bbc0b
https://doi.org/10.1074/jbc.m306894200
https://doi.org/10.1074/jbc.m306894200
Publikováno v:
Journal of Biological Chemistry. 278:14306-14312
Egr1, an immediate early transcription factor, responds to diverse stimuli and affects gene transcription to accomplish its biological effects. One important effect of Egr1 expression is to decrease the growth and tumorigenic potential of several tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c2b3dc1fb8a02e0afbc084a8032601
https://doi.org/10.1074/jbc.m210502200
https://doi.org/10.1074/jbc.m210502200
Publikováno v:
Proceedings of the National Academy of Sciences. 97:14376-14381
The term apoptosis often has been used interchangeably with the term programmed cell death. Here we describe a form of programmed cell death that is distinct from apoptosis by the criteria of morphology, biochemistry, and response to apoptosis inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e58e6e4f3ca48074196fa10f3f30e96
https://doi.org/10.1073/pnas.97.26.14376
https://doi.org/10.1073/pnas.97.26.14376
Publikováno v:
Journal of Biological Chemistry. 274:4400-4411
Re-expression of EGR-1 in fibrosarcoma HT1080 suppresses transformation including tumorigenicity (Huang, R.-P., Liu, C., Fan, Y., Mercola, D., and Adamson, E. (1995) Cancer Res. 55, 5054-5062) owing in part to up-regulation of the transforming growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006600e449b2ed4029c308b44cea3183
https://doi.org/10.1074/jbc.274.7.4400
https://doi.org/10.1074/jbc.274.7.4400
Publikováno v:
The Journal of Cell Biology
Special AT-rich sequence-binding protein 1 (SATB1), a DNA-binding protein expressed predominantly in thymocytes, recognizes an ATC sequence context that consists of a cluster of sequence stretches with well-mixed A's, T's, and C's without G's on one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aacc4027320bbecd803e32a1e525c43d
https://doi.org/10.1083/jcb.141.2.335
https://doi.org/10.1083/jcb.141.2.335