Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Ian Wiid"'
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)
The type I IFN response quickly became associated with its role in the innate immune response to viral infection. The past few years have seen the significance of IFNs expand in breadth to include non-viral pathogens. Previous work has identified tha
Externí odkaz:
https://doaj.org/article/a1387c37cc604135843addefe43b86be
Autor:
Gina Leisching, Ray-Dean Pietersen, Vuyiseka Mpongoshe, Carel van Heerden, Paul van Helden, Ian Wiid, Bienyameen Baker
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153079 (2016)
During Mycobacterium tuberculosis (M.tb) infection, the initial interactions between the pathogen and the host cell determines internalization and innate immune response events. It is established that detergents such as Tween alter the mycobacterial
Externí odkaz:
https://doaj.org/article/0480dddccbfe45f3b5e1ceb9beec63a8
Autor:
Ian Wiid, Christopher J. Parkinson, Jenny Lee Panayides, Richard K. Haynes, Christiaan W. van der Westhuyzen
Publikováno v:
Medicinal Chemistry. 16:392-402
Background:With few exceptions, existing tuberculosis drugs were developed many years ago and resistance profiles have emerged. This has created a need for new drugs with discrete modes of action. There is evidence that tuberculosis (like other bacte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae1e79349d850076cf534fabdbc8c36b
https://doi.org/10.2174/1573406415666190430143535
https://doi.org/10.2174/1573406415666190430143535
Autor:
R.-D. Pietersen, P. D. van Helden, L. Macingwana, C. Mdladla, David L. Tabb, R. Sarkar, Andile H. Ngwane, Bienyameen Baker, Ian Wiid
Publikováno v:
Tuberculosis. 111:78-85
The emerging resistance of tuberculosis (TB) to current first line drugs (isoniazid, rifampicin, pyrazinamide, ethambutol) warrants alternative treatment approaches with broad-spectrum efficacy. Previously, we have shown that sulfamethoxazole (SMX) h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e37e281c461d59770edd12142805a8
https://doi.org/10.1016/j.tube.2018.05.010
https://doi.org/10.1016/j.tube.2018.05.010
Publikováno v:
Journal of Biomedical Science, Vol 25, Iss 1, Pp 1-10 (2018)
Journal of Biomedical Science
Journal of Biomedical Science
Background Three low molecular weight thiols are synthesized by Mycobacterium tuberculosis (M.tb), namely ergothioneine (ERG), mycothiol (MSH) and gamma-glutamylcysteine (GGC). They are able to counteract reactive oxygen species (ROS) and/or reactive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee6f8dd64d5012dd554f892c7a67471
http://link.springer.com/article/10.1186/s12929-018-0458-9
http://link.springer.com/article/10.1186/s12929-018-0458-9
Publikováno v:
The Journal of Infectious Diseases. 217:1517-1521
Evidence to-date points to a detrimental role of the type I IFNs during tuberculosis. The mechanisms underpinning the IFNαβ-mediated exacerbation of the disease is unclear. The 2'-5'-oligoadenylate synthetases (OAS), namely OAS1, OAS2 and OAS3 are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d4038421abcd8fe4ba936ce91716c8
https://doi.org/10.1093/infdis/jiy084
https://doi.org/10.1093/infdis/jiy084
Publikováno v:
Sao Emani, C, Gallant, J L, Wiid, I J & Baker, B 2019, ' The role of low molecular weight thiols in Mycobacterium tuberculosis ', Tuberculosis, vol. 116, pp. 44-55 . https://doi.org/10.1016/j.tube.2019.04.003
Low molecular weight (LMW)thiols are molecules with a functional sulfhydryl group that enable them to detoxify reactive oxygen species, reactive nitrogen species and other free radicals. Their roles range from their ability to modulate the immune sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ddbf07d4a2b3a6d71f98414f5c67cb
https://hdl.handle.net/1871.1/51357284-0a7a-4756-b864-062781eae697
https://hdl.handle.net/1871.1/51357284-0a7a-4756-b864-062781eae697
Autor:
Ray‐Dean Petersen, Bienyameen Baker, Andile H. Ngwane, Richard K. Haynes, Ian Wiid, Ho Ning Wong
The observations that the innate immune system employs copper to eliminate bacterial infection and that resistance to copper enhances virulence of Mycobacterium tuberculosis (Mtb) prompted us to examine the effects the anti-cancer agent elesclomol on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d300b820f94029334c1a98e4d3928289
https://hdl.handle.net/10394/31906
https://hdl.handle.net/10394/31906
Autor:
Gina Leisching, Carel J. van Heerden, Ray-Dean Pietersen, Bienyameen Baker, Ian Wiid, Paul D. van Helden
Publikováno v:
Virulence
The distinguishing factors that characterize the host response to infection with virulent Mycobacterium tuberculosis (M.tb) are largely confounding. We present an infection study with 2 genetically closely related M.tb strains that have vastly differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf435685af1ad6f28bc70cf783c9ef3
https://doi.org/10.1080/21505594.2016.1250994
https://doi.org/10.1080/21505594.2016.1250994
Publikováno v:
Tuberculosis. 100:53-60
The culturing of mycobacteria is a standard procedure that is consistent world-wide, with little variation in the growth media constituents, particularly those found in liquid and solid media. Before the 1940s however, the aggregating nature of mycob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a02e8a9b403b148c2576fcea95a5d53
https://doi.org/10.1016/j.tube.2016.07.002
https://doi.org/10.1016/j.tube.2016.07.002