Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Ian W. Andrews"'
Autor:
Erica J. Zheng, Ian W. Andrews, Alexandra T. Grote, Abigail L. Manson, Miguel A. Alcantar, Ashlee M. Earl, James J. Collins
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Antibiotic tolerance, or the ability of bacteria to survive antibiotic treatment in the absence of genetic resistance, often involves a low metabolic state. Here, Zheng et al. show that tolerance does not readily evolve against antibiotics whose effi
Externí odkaz:
https://doaj.org/article/7c9a36880bc84974902377009584c79c
Autor:
Kyle Swanson, Lindsey A. Carfrae, Eric D. Brown, Jonathan M. Stokes, Kevin Yang, Anush Chiappino-Pepe, George M. Church, Tommi S. Jaakkola, Zohar Bloom-Ackermann, Victoria M. Tran, Regina Barzilay, Craig R. MacNair, James J. Collins, Shawn French, Andres Cubillos-Ruiz, Nina M. Donghia, Ian W. Andrews, Ahmed H. Badran, Wengong Jin, Emma J. Chory
Publikováno v:
Cell
Prof. Collins via Howard Silver
Prof. Collins via Howard Silver
Due to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to discover new antibiotics. To address this challenge, we trained a deep neural network capable of predicting molecules with antibacterial activity. We performed pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3644902a137a3f94eaca8153af34f0d
https://europepmc.org/articles/PMC8349178/
https://europepmc.org/articles/PMC8349178/
Autor:
Michael A. Lobritz, Ian W. Andrews, Dana Braff, Caroline B.M. Porter, Arnaud Gutierrez, Yoshikazu Furuta, Louis B.G. Cortes, Thomas Ferrante, Sarah C. Bening, Felix Wong, Charley Gruber, Christopher W. Bakerlee, Guillaume Lambert, Graham C. Walker, Daniel J. Dwyer, James J. Collins
Publikováno v:
Cell Chem Biol
β-Lactam antibiotics disrupt the assembly of peptidoglycan (PG) within the bacterial cell wall by inhibiting the enzymatic activity of penicillin-binding proteins (PBPs). It was recently shown that β-lactam treatment initializes a futile cycle of P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c6daa0525072bdf5594222864b8102
https://doi.org/10.1016/j.chembiol.2021.12.010
https://doi.org/10.1016/j.chembiol.2021.12.010
Publikováno v:
Prof. Collins via Howard Silver
Antibiotic tolerance, the capacity of genetically susceptible bacteria to survive the lethal effects of antibiotic treatment, plays a critical and underappreciated role in the disease burden of bacterial infections. Here, we take a pathogen-by-pathog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c2313fa42374895ae4e6cd6d7c60f5a
https://doi.org/10.1016/j.cell.2018.01.037
https://doi.org/10.1016/j.cell.2018.01.037
Autor:
James J. Collins, Ivan Matic, Shawn French, Allison J. Lopatkin, Eric D. Brown, Ian W. Andrews, Jonathan M. Stokes, Arnaud Gutierrez
Publikováno v:
Nature Methods
Nature Methods, Nature Publishing Group, 2019, 16 (4), pp.303-306. ⟨10.1038/s41592-019-0333-y⟩
Nature Methods, Nature Publishing Group, 2019, 16 (4), pp.303-306. ⟨10.1038/s41592-019-0333-y⟩
Antibiotic screens typically rely on growth inhibition to characterize compound bioactivity-an approach that cannot be used to assess the bactericidal activity of antibiotics against bacteria in drug-tolerant states. To address this limitation, we de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::826c62717115796cc6c76f1c278b8695
https://hal.archives-ouvertes.fr/hal-02353820
https://hal.archives-ouvertes.fr/hal-02353820
Autor:
Ian W. Andrews, Don O. Maris, Drew L. Sellers, Hua Wei, David S.H. Chu, Lisa R. Volpatti, Suzie H. Pun, Ashton S. Hemphill, Leslie W. Chan, Philip J. Horner
Publikováno v:
Angewandte Chemie. 125:5485-5489
Nucleic acid-based therapeutics, including plasmid DNA (pDNA) and small interfering RNA (siRNA), have been considered highly promising strategies to treat a gamut of diseases.[1] Successful nucleic acid delivery relies on the development of safe and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d3ec844bae08d8d18c9688d712573a
https://doi.org/10.1002/ange.201301896
https://doi.org/10.1002/ange.201301896