Zobrazeno 1 - 10
of 258
pro vyhledávání: '"Ian W Craig"'
Autor:
Chloe Chung Yi Wong, Avshalom Caspi, Benjamin Williams, Renate Houts, Ian W Craig, Jonathan Mill
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17873 (2011)
X-chromosome inactivation (XCI) is a pivotal epigenetic mechanism involved in the dosage compensation of X-linked genes between males and females. In any given cell, the process of XCI in early female development is thought to be random across allele
Externí odkaz:
https://doaj.org/article/7f14a93cfbb845ecbccd845ef3d90c1e
Autor:
Alexandra Schosser, Amy W Butler, Marcus Ising, Nader Perroud, Rudolf Uher, Mandy Y Ng, Sarah Cohen-Woods, Nick Craddock, Michael J Owen, Ania Korszun, Lisa Jones, Ian Jones, Michael Gill, John P Rice, Wolfgang Maier, Ole Mors, Marcella Rietschel, Susanne Lucae, Elisabeth B Binder, Martin Preisig, Julia Perry, Federica Tozzi, Pierandrea Muglia, Katherine J Aitchison, Gerome Breen, Ian W Craig, Anne E Farmer, Bertram Müller-Myhsok, Peter McGuffin, Cathryn M Lewis
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e20690 (2011)
BACKGROUND:Suicidal behaviour can be conceptualised as a continuum from suicidal ideation, to suicidal attempts to completed suicide. In this study we identify genes contributing to suicidal behaviour in the depression study RADIANT. METHODOLOGY/PRIN
Externí odkaz:
https://doaj.org/article/356bdc391a7d4c9b95b76ba53a09f910
Autor:
Ian W. Craig, Charles Curtis, Glyn Lewis, Roy H. Perlis, Anne Farmer, Ole Mors, Richard M. Weinshilboum, Michael Conlon O'Donovan, Hamel Patel, Katherine J. Aitchison, Koen Schruers, Anna Placentino, Gerome Breen, Chiara Fabbri, Katherine E. Tansey, Daniel Souery, Gregory D. Jenkins, Neven Henigsberg, Sang Hyuk Lee, Joanna Hauser, Joanna M. Biernacka, Cathryn M. Lewis, Rudolf Uher, Marcella Rietschel, Stephen Newhouse, Wolfgang Maier, Peter McGuffin
Publikováno v:
Fabbri, C, Tansey, K E, Perlis, R H, Hauser, J, Henigsberg, N, Maier, W, Mors, O, Placentino, A, Rietschel, M, Souery, D, Breen, G, Curtis, C, Lee, S-H, Newhouse, S, Patel, H, O'Donovan, M, Lewis, G, Jenkins, G, Weinshilboum, R M, Farmer, A, Aitchison, K J, Craig, I, McGuffin, P, Schruers, K, Biernacka, J M, Uher, R & Lewis, C M 2018, ' Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects : Meta-analysis of data from genome-wide association studies ', European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, vol. 28, no. 8, pp. 945-954 . https://doi.org/10.1016/j.euroneuro.2018.05.009
European Neuropsychopharmacology, 28(8), 945-954. Elsevier
European Neuropsychopharmacology, 28(8), 945-954. Elsevier
Cytochrome (CYP) P450 enzymes have a primary role in antidepressant metabolism and variants in these polymorphic genes are targets for pharmacogenetic investigation. This is the first meta-analysis to investigate how CYP2C19 polymorphisms predict cit
Autor:
Ania Korszun, Konstantinos Douroudis, Helen L. Fisher, Georgina M. Hosang, David Stacey, Diana Ahmetspahic, Peter McGuffin, Udo Dannlowski, Nicholas John Craddock, Ian W. Craig, Cathryn M. Lewis, Anne Farmer, Bernard T. Baune, Michael John Owen, Rudolf Uher, Gerome Breen, Sarah Cohen-Woods, Volker Arolt
Publikováno v:
Cohen-Woods, S, Fisher, H L, Ahmetspahic, D, Douroudis, K, Stacey, D, Hosang, G M, Korszun, A, Owen, M, Craddock, N, Arolt, V, Dannowski, U, Breen, G, Craig, I W, Farmer, A, Baune, B T, Lewis, C M, Uher, R & McGuffin, P 2017, ' Interaction between childhood maltreatment on immunogenetic risk in depression : discovery and replication in clinical case-control samples ', Brain, Behavior, and Immunity, vol. 67, pp. 203-210 . https://doi.org/10.1016/j.bbi.2017.08.023
Major depressive disorder (MDD) is a prevalent disorder with moderate heritability. Both MDD and interpersonal adversity, including childhood maltreatment, have been consistently associated with elevated inflammatory markers. We investigated interact
Autor:
Bertram Müller-Myhsok, Adam E. Locke, F. Tozzi, Martin Preisig, Gérard Waeber, James Rucker, Marcella Rietschel, Yuri Milaneschi, Susanne Lucae, Cathryn M. Lewis, Katherine J. Aitchison, Ana Ching-López, Sara Cohen-Woods, Ian W. Craig, Anne Farmer, Ole Mors, Gonneke Willemsen, Michael Gill, Peter Vollenweider, Gerome Breen, Michael John Owen, Stefan Kloiber, Peter McGuffin, Brenda W.J.H. Penninx, Zoltán Kutalik, Dorret I. Boomsma, Rudolf Uher, Tanguy Corre, Nicholas John Craddock, Florian Holsboer, Sven Bergmann, Wolfgang Maier, Margarita Rivera, John P. Rice, Jouke-Jan Hottenga, Darina Czamara, Christiane Wolf, Ania Korszun
Publikováno v:
Rivera, M, Locke, A E, Corre, T, Czamara, D, Wolf, C, Ching-Lopez, A, Milaneschi, Y, Kloiber, S, Cohen-Woods, S, Rucker, J, Aitchison, K J, Bergmann, S, Boomsma, D I, Craddock, N, Gill, M, Holsboer, F, Hottenga, J-J, Korszun, A, Kutalik, Z, Lucae, S, Maier, W, Mors, O, Müller-Myhsok, B, Owen, M J, Penninx, B W J H, Preisig, M, Rice, J, Rietschel, M, Tozzi, F, Uher, R, Vollenweider, P, Waeber, G, Willemsen, G, Craig, I W, Farmer, A E, Lewis, C M, Breen, G & McGuffin, P 2017, ' Interaction between the FTO gene, body mass index and depression : meta-analysis of 13701 individuals ', The British journal of psychiatry : the journal of mental science, vol. 211, no. 2, pp. 70-76 . https://doi.org/10.1192/bjp.bp.116.183475
Rivera, M, Locke, A E, Corre, T, Czamara, D, Wolf, C, Ching-Lopez, A, Milaneschi, Y, Kloiber, S, Cohen-Woods, S, Rucker, J, Aitchison, K J, Bergmann, S, Boomsma, D I, Craddock, N, Gill, M, Holsboer, F, Hottenga, J-J, Korszun, A, Kutalik, Z, Lucae, S, Maier, W, Mors, O, Müller-Myhsok, B, Owen, M J, Penninx, B W J H, Preisig, M, Rice, J P, Rietschel, M, Tozzi, F, Uher, R, Vollenweider, P, Waeber, G, Willemsen, G, Craig, I W, Farmer, A E, Lewis, C M, Breen, G & McGuffin, P 2017, ' Interaction between the FTO gene, body mass index and depression : meta-analysis of 13701 individuals ', British Journal of Psychiatry, vol. 211, no. 2, pp. 70-76 . https://doi.org/10.1192/bjp.bp.116.183475
Rivera, M, Locke, A E, Corre, T, Czamara, D, Wolf, C, Ching-Lopez, A, Milaneschi, Y, Kloiber, S, Cohen-Woods, S, Rucker, J, Aitchison, K J, Bergmann, S, Boomsma, D I, Craddock, N, Gill, M, Holsboer, F, Hottenga, J-J, Korszun, A, Kutalik, Z, Lucae, S, Maier, W, Mors, O, Müller-Myhsok, B, Owen, M J, Penninx, B W J H, Preisig, M, Rice, J, Rietschel, M, Tozzi, F, Uher, R, Vollenweider, P, Waeber, G, Willemsen, G, Craig, I W, Farmer, A E, Lewis, C M, Breen, G & McGuffin, P 2017, ' Interaction between the FTO gene, body mass index and depression : meta-analysis of 13701 individuals ', The British journal of psychiatry : the journal of mental science . https://doi.org/10.1192/bjp.bp.116.183475
BRITISH JOURNAL OF PSYCHIATRY
British Journal of Psychiatry, 211(2), 70-76. Royal College of Psychiatrists
Rivera, M, Locke, A E, Corre, T, Czamara, D, Wolf, C, Ching-Lopez, A, Milaneschi, Y, Kloiber, S, Cohen-Woods, S, Rucker, J, Aitchison, K J, Bergmann, S, Boomsma, D I, Craddock, N, Gill, M, Holsboer, F, Hottenga, J-J, Korszun, A, Kutalik, Z, Lucae, S, Maier, W, Mors, O, Mueller-Myhsok, B, Owen, M J, Penninx, B W J H, Preisig, M, Rice, J, Rietschel, M, Tozzi, F, Uher, R, Vollenweider, P, Waeber, G, Willemsen, G, Craig, I W, Farmer, A E, Lewis, C M, Breen, G & McGuffin, P 2017, ' Interaction between the FTO gene, body mass index and depression: meta-analysis of 13701 individualst ', British Journal of Psychiatry, vol. 211, no. 2, pp. 70-76 . https://doi.org/10.1192/bjp.bp.116.183475
Rivera, M, Locke, A E, Corre, T, Czamara, D, Wolf, C, Ching-Lopez, A, Milaneschi, Y, Kloiber, S, Cohen-Woods, S, Rucker, J, Aitchison, K J, Bergmann, S, Boomsma, D I, Craddock, N, Gill, M, Holsboer, F, Hottenga, J-J, Korszun, A, Kutalik, Z, Lucae, S, Maier, W, Mors, O, Müller-Myhsok, B, Owen, M J, Penninx, B W J H, Preisig, M, Rice, J P, Rietschel, M, Tozzi, F, Uher, R, Vollenweider, P, Waeber, G, Willemsen, G, Craig, I W, Farmer, A E, Lewis, C M, Breen, G & McGuffin, P 2017, ' Interaction between the FTO gene, body mass index and depression : meta-analysis of 13701 individuals ', British Journal of Psychiatry, vol. 211, no. 2, pp. 70-76 . https://doi.org/10.1192/bjp.bp.116.183475
Rivera, M, Locke, A E, Corre, T, Czamara, D, Wolf, C, Ching-Lopez, A, Milaneschi, Y, Kloiber, S, Cohen-Woods, S, Rucker, J, Aitchison, K J, Bergmann, S, Boomsma, D I, Craddock, N, Gill, M, Holsboer, F, Hottenga, J-J, Korszun, A, Kutalik, Z, Lucae, S, Maier, W, Mors, O, Müller-Myhsok, B, Owen, M J, Penninx, B W J H, Preisig, M, Rice, J, Rietschel, M, Tozzi, F, Uher, R, Vollenweider, P, Waeber, G, Willemsen, G, Craig, I W, Farmer, A E, Lewis, C M, Breen, G & McGuffin, P 2017, ' Interaction between the FTO gene, body mass index and depression : meta-analysis of 13701 individuals ', The British journal of psychiatry : the journal of mental science . https://doi.org/10.1192/bjp.bp.116.183475
BRITISH JOURNAL OF PSYCHIATRY
British Journal of Psychiatry, 211(2), 70-76. Royal College of Psychiatrists
Rivera, M, Locke, A E, Corre, T, Czamara, D, Wolf, C, Ching-Lopez, A, Milaneschi, Y, Kloiber, S, Cohen-Woods, S, Rucker, J, Aitchison, K J, Bergmann, S, Boomsma, D I, Craddock, N, Gill, M, Holsboer, F, Hottenga, J-J, Korszun, A, Kutalik, Z, Lucae, S, Maier, W, Mors, O, Mueller-Myhsok, B, Owen, M J, Penninx, B W J H, Preisig, M, Rice, J, Rietschel, M, Tozzi, F, Uher, R, Vollenweider, P, Waeber, G, Willemsen, G, Craig, I W, Farmer, A E, Lewis, C M, Breen, G & McGuffin, P 2017, ' Interaction between the FTO gene, body mass index and depression: meta-analysis of 13701 individualst ', British Journal of Psychiatry, vol. 211, no. 2, pp. 70-76 . https://doi.org/10.1192/bjp.bp.116.183475
BackgroundDepression and obesity are highly prevalent, and major impacts on public health frequently co-occur. Recently, we reported that having depression moderates the effect of the FTO gene, suggesting its implication in the association between de
Autor:
Peter McGuffin, Mojca Z. Dernovsek, Ian W. Craig, Katherine J. Aitchison, Annamaria Cattaneo, Astrid Zobel, Marcella Rietschel, Joanna Hauser, Anne Farmer, Ole Mors, Chiara Fabbri, Hongyan Ren, Rudolf Uher, Daniel Souery, Wolfgang Maier, Gerome Breen, Neven Henigsberg, Cathryn M. Lewis
Publikováno v:
Ren, H, Fabbri, C, Uher, R, Rietschel, M, Mors, O, Henigsberg, N, Hauser, J, Zobel, A, Maier, W, Dernovsek, M Z, Souery, D, Cattaneo, A, Breen, G, Craig, I W, Farmer, A E, McGuffin, P, Lewis, C M & Aitchison, K J 2018, ' Genes associated with anhedonia : a new analysis in a large clinical trial (GENDEP) ', Translational Psychiatry, vol. 8, no. 1, 150 . https://doi.org/10.1038/s41398-018-0198-3
Translational Psychiatry, Vol 8, Iss 1, Pp 1-11 (2018)
Translational Psychiatry, 8 (1
Translational Psychiatry
Translational Psychiatry, Vol 8, Iss 1, Pp 1-11 (2018)
Translational Psychiatry, 8 (1
Translational Psychiatry
A key feature of major depressive disorder (MDD) is anhedonia, which is a predictor of response to antidepressant treatment. In order to shed light on its genetic underpinnings, we conducted a genome-wide association study (GWAS) followed by investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cec981be8dbb7fb7d4154bf931802152
https://pure.au.dk/portal/da/publications/genes-associated-with-anhedonia(cc83fae3-316a-45ae-ab88-f6e89502bc0f).html
https://pure.au.dk/portal/da/publications/genes-associated-with-anhedonia(cc83fae3-316a-45ae-ab88-f6e89502bc0f).html
Autor:
Gerome Breen, Joanna M. Biernacka, Anna Placentino, Daniel Souery, Lee Sang-Hyuk, Glyn Lewis, Anne Farmer, Ole Mors, Hamel Patel, Michael Conlon O'Donovan, Richard M. Weinshilboum, Joanna Hauser, Ian W. Craig, Guido Bondolfi, Chiara Fabbri, Charles Curtis, Rudolf Uher, Stephen Newhouse, Katherine J. Aitchison, Michel Guipponi, Marcella Rietschel, Peter McGuffin, Nader Perroud, Wolfgang Maier, Cathryn M. Lewis, Neven Henigsberg, Katherine E. Tansey, Roy H. Perlis
Publikováno v:
Fabbri, C, Tansey, K, Perlis, R, Hauser, J, Henigsberg, N, Maier, W, Mors, O, Placentino, A, Rietschel, M, Souery, D, Breen, G, Curtis, C, Sang-Hyuk, L, Newhouse, S, Patel, H, Guipponi, M, Perroud, N, Bondolfi, G, O'Donovan, M, Lewis, G, Biernacka, J, Weinshilboum, R, Farmer, A, Aitchison, K, Craig, I, McGuffin, P, Uher, R & Lewis, C 2018, ' New insights on the pharmacogenomics of antidepressant response from the GENDEP and STAR*D studies : rare variant analysis and high-density imputation ', The pharmacogenomics journal, vol. 18, pp. 413-421 .
Genome-wide association studies have generally failed to identify polymorphisms associated with antidepressant response. Possible reasons include limited coverage of genetic variants that this study tried to address by exome genotyping and dense impu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62c0b9f5cab8118c57d4e110a84aac01
https://kclpure.kcl.ac.uk/portal/en/publications/new-insights-on-the-pharmacogenomics-of-antidepressant-response-from-the-gendep-and-stard-studies(07e86c7e-570f-4159-9961-0fd6161fe7ca).html
https://kclpure.kcl.ac.uk/portal/en/publications/new-insights-on-the-pharmacogenomics-of-antidepressant-response-from-the-gendep-and-stard-studies(07e86c7e-570f-4159-9961-0fd6161fe7ca).html
Autor:
Anne Farmer, Ole Mors, Neven Henigsberg, Peter McGuffin, Michael Conlon O'Donovan, Gerome Breen, Nader Perroud, Cathryn M. Lewis, Roy H. Perlis, Glyn Lewis, Anna Placentino, Joanna M. Biernacka, Richard M. Weinshilboum, Marcella Rietschel, Charles Curtis, Rudolf Uher, Katherine J. Aitchison, Katherine E. Tansey, Michel Guipponi, Guido Bondolfi, Hamel Patel, Chiara Fabbri, Ian W. Craig, Stephen Newhouse, Wolfgang Maier, Joanna Hauser, Daniel Souery, Lee Sang-Hyuk
Publikováno v:
Fabbri, C, Tansey, K E, Perlis, R H, Hauser, J, Henigsberg, N, Maier, W, Mors, O, Placentino, A, Rietschel, M, Souery, D, Breen, G, Curtis, C, Sang-Hyuk, L, Newhouse, S, Patel, H, Guipponi, M, Perroud, N, Bondolfi, G, O'Donovan, M, Lewis, G, Biernacka, J M, Weinshilboum, R M, Farmer, A, Aitchison, K J, Craig, I, McGuffin, P, Uher, R & Lewis, C M 2018, ' New insights into the pharmacogenomics of antidepressant response from the GENDEP and STAR*D studies : rare variant analysis and high-density imputation ', The Pharmacogenomics Journal, vol. 18, no. 3, pp. 413-421 . https://doi.org/10.1038/tpj.2017.44
The Pharmacogenomics Journal (2017)
Pharmacogenomics J
The Pharmacogenomics Journal (2017)
Pharmacogenomics J
Genome-wide association studies have generally failed to identify polymorphisms associated with antidepressant response. Possible reasons include limited coverage of genetic variants that this study tried to address by exome genotyping and dense impu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::764bd9a4401a92501c422a7da7c165c8
https://pure.au.dk/portal/da/publications/new-insights-into-the-pharmacogenomics-of-antidepressant-response-from-the-gendep-and-stard-studies(b452a5b2-7a2b-4979-993c-8914b3584e09).html
https://pure.au.dk/portal/da/publications/new-insights-into-the-pharmacogenomics-of-antidepressant-response-from-the-gendep-and-stard-studies(b452a5b2-7a2b-4979-993c-8914b3584e09).html
Autor:
Michele L. Pergadia, Grant W. Montgomery, Nicholas G. Martin, Lannie Ligthart, Cathryn M. Lewis, Ian W. Craig, Gerome Breen, Jouke-Jan Hottenga, Dorret I. Boomsma, Gonneke Willemsen, Enda M. Byrne, Pamela A. F. Madden, Anne Farmer, Peter McGuffin, Christel M. Middeldorp, Brenda W.J.H. Penninx, Jacqueline M. Vink, Dale R. Nyholt, Andrew C. Heath
Publikováno v:
Ligthart, L, Hottenga, J J, Lewis, C M, Farmer, A E, Craig, I W, Breen, G, Willemsen, G, Vink, J M, Middeldorp, C M, Byrne, E M, Heath, A C, Madden, P A F, Pergadia, M L, Montgomery, G W, Martin, N G, Penninx, B W J H, McGuffin, P, Boomsma, D I & Nyholt, DR 2014, ' Genetic risk score analysis indicates migraine with and without comorbid depression are genetically different disorders ', Human Genetics, vol. 133, no. 2, pp. 173-186 . https://doi.org/10.1007/s00439-013-1370-8
Ligthart, R S L, Hottenga, J J, Lewis, C M, Farmer, A E, Craig, I W, Breen, G, Willemsen, G, Vink, J M, Middeldorp, C M, Byrne, E M, Heath, A C, Madden, P A F, Pergadia, M L, Montgomery, G W, Martin, N G, Penninx, B W J H, McGuffin, P, Boomsma, D I & Nyholt, DR 2014, ' Genetic risk score analysis indicates migraine with and without comorbid depression are genetically different disorders ', Human Genetics, vol. 133, no. 2, pp. 173-186 . https://doi.org/10.1007/s00439-013-1370-8
Human Genetics, 133(2), 173-186. Springer Verlag
Human Genetics
Ligthart, R S L, Hottenga, J J, Lewis, C M, Farmer, A E, Craig, I W, Breen, G, Willemsen, G, Vink, J M, Middeldorp, C M, Byrne, E M, Heath, A C, Madden, P A F, Pergadia, M L, Montgomery, G W, Martin, N G, Penninx, B W J H, McGuffin, P, Boomsma, D I & Nyholt, DR 2014, ' Genetic risk score analysis indicates migraine with and without comorbid depression are genetically different disorders ', Human Genetics, vol. 133, no. 2, pp. 173-186 . https://doi.org/10.1007/s00439-013-1370-8
Human Genetics, 133(2), 173-186. Springer Verlag
Human Genetics
Migraine and major depressive disorder (MDD) are comorbid, moderately heritable and to some extent influenced by the same genes. In a previous paper, we suggested the possibility of causality (one trait causing the other) underlying this comorbidity.