Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Ian Travers Crosby"'
Autor:
Patrick M. Sexton, Celine Valant, Arthur Christopoulos, Benvenuto Capuano, Tracey Huynh, Ian Travers Crosby
Publikováno v:
ACS Chemical Neuroscience. 6:838-844
The M4 mAChR is implicated in several CNS disorders and possesses an allosteric binding site for which ligands modulating the affinity and/or efficacy of ACh may be exploited for selective receptor targeting. We report the synthesis of a focused libr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c4d1b6d39f3958df8c12fb3fce2ea8
https://doi.org/10.1021/acschemneuro.5b00035
https://doi.org/10.1021/acschemneuro.5b00035
Publikováno v:
Anti-Infective Agents. 12:80-84
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2006bd1e3b56fb629b730050f2d56350
https://doi.org/10.2174/22113525113119990116
https://doi.org/10.2174/22113525113119990116
Autor:
Tracey Huynh, Patrick M. Sexton, Celine Valant, Arthur Christopoulos, Benvenuto Capuano, Ian Travers Crosby
Publikováno v:
Journal of Medicinal Chemistry. 56:8196-8200
The M4 mAChR is implicated in several CNS disorders and possesses an allosteric binding site for which ligands modulating the affinity and/or efficacy of ACh may be exploited for selective receptor targeting. We report the synthesis of a focused libr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::501734dfca9516273b4247d019f845ad
https://doi.org/10.1021/jm401032k
https://doi.org/10.1021/jm401032k
Autor:
Ian Travers Crosby, Alan D. Robertson, Celine Valant, Arthur Christopoulos, Richard G. Conway, Benvenuto Capuano
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:2560-2564
A series of substituted 4-arylpiperidines and a smaller family of 4-aryl-1,2,3,6-tetrahydropyridines were synthesized and their biological activity at the 5-HT(2C) receptor studied to determine whether either series showed noteworthy agonist activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b4bed0f0a65f133dd0caa6dc4f6ad1b
https://doi.org/10.1016/j.bmcl.2012.01.122
https://doi.org/10.1016/j.bmcl.2012.01.122
Publikováno v:
Med. Chem. Commun.. 3:244-249
A series of substituted 2-hydroxybenzoic acid derivatives were synthesized as simplified analogues of platensimycin. The final compounds were evaluated against the Gram-positive bacteria, methicillin-resistant Staphylococcus aureus. Analogues that po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f1e86c337cb2a602f232fb110fcb81b
https://doi.org/10.1039/c2md00252c
https://doi.org/10.1039/c2md00252c
Publikováno v:
Current Medicinal Chemistry. 18:1380-1404
The treatment of schizophrenia, one of the most debilitating mental illnesses, began by the serendipitous discovery of chlorpromazine. Since then, researchers have endeavored to find the cause of the illness but it remains unresolved. As a result, li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eed7ab7f8ccd9082d38b6601c51f726
https://doi.org/10.2174/092986711795029546
https://doi.org/10.2174/092986711795029546
Autor:
Jonathan Coates, Eric Dale Jones, Susan Cox, Nick Vandegraaff, Paula J De Bruyn, David Rhodes, David Gerard Bourke, Alan D. Robertson, Ian Travers Crosby
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:6442-6450
The synthesis of a new series of conocurvone analogues is presented that explores the importance of the pyran rings of conocurvone, their degree of unsaturation as well as the role of alkoxy functionalities as pyran ring replacements, for the inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a1c921fee6cadfbe49a91686c20c903
https://doi.org/10.1016/j.bmc.2010.06.105
https://doi.org/10.1016/j.bmc.2010.06.105
Autor:
Amelia Vom, Ian Travers Crosby, Benvenuto Capuano, Elizabeth Yuriev, Fiona M. McRobb, Vladimir V Moudretski, Craig M. Forsyth, David A Taylor
Publikováno v:
Structural Chemistry. 21:613-628
Schizophrenia is a debilitating mental disorder which affects approximately 1% of the world’s population. Clozapine is an atypical antipsychotic showing unmatched effectiveness in the control of treatment-resistant schizophrenia. Unlike typical ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67dac06ee61069ebe88f5e8920b586f2
https://doi.org/10.1007/s11224-010-9591-0
https://doi.org/10.1007/s11224-010-9591-0
Autor:
Juliette E Neve, Benny Capuano, Gary D. Fallon, Ian Travers Crosby, S Egan, Edward John Lloyd
Publikováno v:
Acta Crystallographica Section E Structure Reports Online. 61:o20-o22
The structure of the title compound, C25H23Cl2N5O·CH2Cl2, confirms the presence of the buckled nature of the dibenzodiazepine nucleus, with the central seven-membered heterocycle in a boat conformation, the dihedral angle between the planes of the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b07cbd9f8fdf808af79f1d29a310ce39
https://doi.org/10.1107/s1600536804031095
https://doi.org/10.1107/s1600536804031095
Autor:
Ian Travers Crosby, Edward John Lloyd, Elizabeth Yuriev, S Egan, Benny Capuano, Gary D. Fallon
Publikováno v:
Acta Crystallographica Section E Structure Reports Online. 59:o1367-o1369
The thienobenzodiazepine nucleus of the title compound, olanzapine methanol solvate monohydrate, C17H20N4S·CH4O·H2O, is buckled, with the central seven-membered heterocycle in a boat conformation and the dihedral angle between the planes of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::183629d78ca8f80c7aec28df688ff9d1
https://doi.org/10.1107/s1600536803017744
https://doi.org/10.1107/s1600536803017744