USP7 inhibitors suppress tumour neoangiogenesis and promote synergy with immune checkpoint inhibitors by downregulating fibroblast VEGF

Autor: Anamarija Jurisic, Pei‐Ju Sung, Mark Wappett, Julien Daubriac, Ian T. Lobb, Wei‐Wei Kung, Nyree Crawford, Natalie Page, Eamon Cassidy, Stephanie Feutren‐Burton, J. S. Shane Rountree, Matthew D. Helm, Colin R. O'Dowd, Richard D. Kennedy, Gerald Gavory, Aaron N. Cranston, Daniel B. Longley, Xavier Jacq, Timothy Harrison

Publikováno v: Clinical and Translational Medicine, Vol 14, Iss 4, Pp n/a-n/a (2024)

Abstract Background Understanding how to modulate the microenvironment of tumors that are resistant to immune checkpoint inhibitors represents a major challenge in oncology.Here we investigate the ability of USP7 inhibitors to reprogram the tumor mic

Externí odkaz: https://doaj.org/article/c9655525645b43019fcffa228b383b32

SynLeGG: analysis and visualization of multiomics data for discovery of cancer ‘Achilles Heels’ and gene function relationships

Autor: Adam Harris, Mark Wappett, Simon S. McDade, Alexander L. R. Lubbock, Ian T Lobb, Ian M. Overton

Publikováno v: Wappett, M, Harris, A, Lubbock, A L R, Lobb, I, McDade, S & Overton, IM 2021, ' SynLeGG: analysis and visualization of multiomics data for discovery of cancer ‘Achilles Heels’ and gene function relationships ', Nucleic Acids Research, vol. 49, no. W1, pp. W613-W618 . https://doi.org/10.1093/nar/gkab338
Nucleic Acids Research

Achilles’ heel relationships arise when the status of one gene exposes a cell's vulnerability to perturbation of a second gene, such as chemical inhibition, providing therapeutic opportunities for precision oncology. SynLeGG (www.overton-lab.uk/syn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90991faf31ecb8c840952138607a6459
https://pure.qub.ac.uk/en/publications/c499bc1a-2c62-4d04-83f6-b69dfb1eca49

The HIF complex recruits the histone methyltransferase SET1B to activate specific hypoxia-inducible genes

Autor: Ana Peñalver, James McCaffrey, Patrick H. Maxwell, James A. Nathan, Louise H Jordon, Natalie Burrows, Niek Wit, Olivia Lombardi, Rachel Seear, Ian T Lobb, David R. Mole, Brian Ortmann, Peter S. J. Bailey, Peter J. Ratcliffe, Esther Arnaiz

Publikováno v: Nature genetics

Hypoxia-inducible transcription factors (HIFs) are fundamental to the cellular adaptation to low oxygen levels but it is unclear how they interact with chromatin and activate their target genes. Here we use genome-wide mutagenesis to identify genes i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd37dfd7b43135f9938db75b39eb92e8
https://pubmed.ncbi.nlm.nih.gov/34155378

A role for the autophagic receptor, SQSTM1/p62, in trafficking NF-κB/RelA to nucleolar aggresomes

Autor: Karl C.F. Olsen, Ian T Lobb, Rory R. Duncan, Xhordi Lieshi, Kirsty J. Martin, Lesley A. Stark, Pierre Morin

Elevated NF-κB activity is a contributory factor in many haematological and solid malignancies. Nucleolar sequestration of NF-κB/RelA represses this elevated activity and mediates apoptosis of cancer cells. Here we set out to understand the mechani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8039ba4a242fdafb45f950cf40032c1b

Identification of a novel TIF-IA-NF-κB nucleolar stress response pathway

Autor: Jingyu, Chen, Ian T, Lobb, Pierre, Morin, Sonia M, Novo, James, Simpson, Kathrin, Kennerknecht, Alex, von Kriegsheim, Emily E, Batchelor, Fiona, Oakley, Lesley A, Stark

Publikováno v: Nucleic Acids Research

p53 as an effector of nucleolar stress is well defined, but p53 independent mechanisms are largely unknown. Like p53, the NF-κB transcription factor plays a critical role in maintaining cellular homeostasis under stress. Many stresses that stimulate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::235bd62c77be14d228e5be1385f4a77d
https://pubmed.ncbi.nlm.nih.gov/29873780