Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Ian Stansfield"'
ExpressInHost: A Codon Tuning Tool for the Expression of Recombinant Proteins in Host Microorganisms
Publikováno v:
Journal of Open Research Software, Vol 11, Iss 1, Pp 2-2 (2023)
ExpressInHost (https://gitlab.com/a.raguin/expressinhost) is a GTK/C++ based user friendly graphical interface that allows tuning the codon sequence of an mRNA for recombinant protein expression in a host microorganism. Heterologous gene expression i
Externí odkaz:
https://doaj.org/article/fd03323f53544df3a4667c9b4c8f003d
Publikováno v:
Frontiers in Molecular Biosciences, Vol 6 (2019)
The cytoplasm is a densely packed environment filled with macromolecules with hindered diffusion. Molecular simulation of the diffusion of biomolecules under such macromolecular crowding conditions requires the definition of a simulation cell with a
Externí odkaz:
https://doaj.org/article/87c19c14bcf3425cb2caed8c62669f5d
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 5, p e1005555 (2017)
The well established phenomenon of ribosome drop-off plays crucial roles in translational accuracy and nutrient starvation responses during protein translation. When cells are under stress conditions, such as amino acid starvation or aminoacyl-tRNA d
Externí odkaz:
https://doaj.org/article/05c502fe70c640aa8cc15a203b7b180f
Publikováno v:
Cells, Vol 8, Iss 8, p 800 (2019)
In eukaryotes, the binding of poly(A) binding protein (PAB) to the poly(A) tail is central to maintaining mRNA stability. PABP interacts with the translation termination apparatus, and with eIF4G to maintain 3′−5′ mRNA interactions as part of a
Externí odkaz:
https://doaj.org/article/968435b3274d4d498f77c19ebaf7f724
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 1, p e1002866 (2013)
To understand the complex relationship governing transcript abundance and the level of the encoded protein, we integrate genome-wide experimental data of ribosomal density on mRNAs with a novel stochastic model describing ribosome traffic dynamics du
Externí odkaz:
https://doaj.org/article/d9d0f10823684ce6a9ac28480eb6f4e7
Publikováno v:
Physical Review E. 105
We extend the paradigmatic and versatile totally asymmetric simple exclusion process (TASEP) for stochastic 1D transport to allow for two different particle species, each having specific entry and exit rates. We offer a complete mean-field analysis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc82593f29a1ed5e94c255e2b3b36959
https://doi.org/10.1103/physreve.105.034117
https://doi.org/10.1103/physreve.105.034117
Autor:
Matthias Versele, Herman van Vlijmen, Lieven Meerpoel, Edgar Jacoby, Olivier Alexis Georges Querolle, George Hynd, Ian Stansfield, Ricardo Attar
Publikováno v:
Future Drug Discovery. 2
In the search for first-in-class NIK inhibitors for multiple myeloma, we discovered an azaindoline hit class generated from a biochemical NIK autophosphorylation high-throughput screening assay which was optimized to the final cyanoindoline compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f087f9fdc38c061745822fa4500407dd
https://doi.org/10.4155/fdd-2020-0004
https://doi.org/10.4155/fdd-2020-0004
Autor:
Didier Berthelot, Janine Cossy, Ian Stansfield, Pierre-Antoine Nocquet, Patrick René Angibaud, Andrei Corbu, Lieven Meerpoel
Publikováno v:
European Journal of Organic Chemistry. 2017:3343-3354
trans-2,3-Diaryl(heteroaryl) dihydropyrans were synthesized by an allylboration/ring-closing metathesis sequence, using allylboranes formed in situ from the corresponding allylic alcohol. Aryl(heteroaryl) substituents were thus installed dia-stereose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a176f3fcef4580944d00baf29e5da01c
https://doi.org/10.1002/ejoc.201700448
https://doi.org/10.1002/ejoc.201700448
Autor:
Lieven Meerpoel, Ian Stansfield, Sébastien Reymond, Janine Cossy, Lionel Nicolas, Patrick René Angibaud
Publikováno v:
Tetrahedron Letters. 55:849-852
An array of C-aryl furanosides was prepared in good yields from furanosyl halides and aryl Grignard reagents in Et2O using PPh3 as a catalyst.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94b9a66b3bb2f9f94796900179c8d4cc
https://doi.org/10.1016/j.tetlet.2013.12.035
https://doi.org/10.1016/j.tetlet.2013.12.035
Autor:
Lionel Nicolas, Lieven Meerpoel, Janine Cossy, Ian Stansfield, Sébastien Reymond, Patrick René Angibaud, Eva Izquierdo
Publikováno v:
The Journal of Organic Chemistry. 78:11807-11814
An array of C-aryl and C-vinyl furanosides were prepared in good yields and diastereoselectivities from C-halogeno furanosides either with aryl Grignard or with vinyl Grignard using the convenient Co(acac)3/TMEDA catalytic system. This method is illu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d599cf26827b8c91bf2a49219279857e
https://doi.org/10.1021/jo401845q
https://doi.org/10.1021/jo401845q