Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Ian Spendlove"'
Autor:
Shahd Talhouni, Wakkas Fadhil, Nigel P. Mongan, Lara Field, Kelly Hunter, Sogand Makhsous, Alexandre Maciel-Guerra, Nayandeep Kaur, Ausrine Nestarenkaite, Arvydas Laurinavicius, Benjamin E. Willcox, Tania Dottorini, Ian Spendlove, Andrew M. Jackson, Mohammad Ilyas, Judith M. Ramage
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionCharacterization of the tumour immune infiltrate (notably CD8+ T-cells) has strong predictive survival value for cancer patients. Quantification of CD8 T-cells alone cannot determine antigenic experience, as not all infiltrating T-cells r
Externí odkaz:
https://doaj.org/article/6b4dd9401ad44bb09a15e0543609a433
Autor:
Jehan Aram, Nanci Frakich, Elena Morandi, Mohammed Alrouji, Amal Samaraweera, David Onion, Ian Spendlove, Sergio L. Colombo, Radu Tanasescu, Bruno Gran, Cris S. Constantinescu
Publikováno v:
Biomedicines, Vol 8, Iss 7, p 226 (2020)
Granulocyte macrophage colony stimulating factor (GM-CSF) is a pro-inflammatory cytokine produced by immune cells. Recent evidence suggests that GM-CSF plays an important role in multiple sclerosis (MS) pathogenesis. We investigated the expression an
Externí odkaz:
https://doaj.org/article/7b2256fcc7524635bc3cf7bf20777719
Autor:
Daniel E Foxler, Katherine S Bridge, John G Foster, Paul Grevitt, Sean Curry, Kunal M Shah, Kathryn M Davidson, Ai Nagano, Emanuela Gadaleta, Hefin I Rhys, Paul T Kennedy, Miguel A Hermida, Ting‐Yu Chang, Peter E Shaw, Louise E Reynolds, Tristan R McKay, Hsei‐Wei Wang, Paulo S Ribeiro, Michael J Plevin, Dimitris Lagos, Nicholas R Lemoine, Prabhakar Rajan, Trevor A Graham, Claude Chelala, Kairbaan M Hodivala‐Dilke, Ian Spendlove, Tyson V Sharp
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 8, Pp n/a-n/a (2018)
Abstract The adaptive cellular response to low oxygen tensions is mediated by the hypoxia‐inducible factors (HIFs), a family of heterodimeric transcription factors composed of HIF‐α and HIF‐β subunits. Prolonged HIF expression is a key contri
Externí odkaz:
https://doaj.org/article/9b04680e29334b599d9575042b42aeeb
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e54892 (2013)
Several monoclonal antibodies (mAbs) recognising Lewis(y), such as BR96, have reached the clinic but have failed to show good anti-tumour responses with an acceptable level of toxicity. No Lewis(b) mAbs have been trialled in patients. In this study w
Externí odkaz:
https://doaj.org/article/caf89600bef145b39f592b886d8c3fa4
Autor:
Lindy G. Durrant, Srinivasan Madhusudan, Abid M. Zaitoun, Ian Spendlove, Tina Parsons, Robert Moss, Philip A. Clarke, Richard S. McIntosh, Mireille Vankemmelbeke, Jia Xin Chua
Supplementary Figure 3. containing direct cytotoxic activity of FG88.2: PI uptake and WST-8 assay. DNA fragmentation analysis of FG88-treated cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b63f3f289aeef037524a694a8a5b663
https://doi.org/10.1158/1078-0432.22457454
https://doi.org/10.1158/1078-0432.22457454
Autor:
Lindy G. Durrant, Srinivasan Madhusudan, Abid M. Zaitoun, Ian Spendlove, Tina Parsons, Robert Moss, Philip A. Clarke, Richard S. McIntosh, Mireille Vankemmelbeke, Jia Xin Chua
Purpose: To produce antitumor monoclonal antibodies (mAbs) targeting glycans as they are aberrantly expressed in tumors and are coaccessory molecules for key survival pathways.Experimental Design: Two mAbs (FG88.2 and FG88.7) recognizing novel tumor-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc7790fc293f35bcec545d628fdaa2f
https://doi.org/10.1158/1078-0432.c.6523581.v1
https://doi.org/10.1158/1078-0432.c.6523581.v1
Autor:
Lindy G. Durrant, Srinivasan Madhusudan, Abid M. Zaitoun, Ian Spendlove, Tina Parsons, Robert Moss, Philip A. Clarke, Richard S. McIntosh, Mireille Vankemmelbeke, Jia Xin Chua
Supplementary Figure 1. containing Lewis glycan competition analysis, Lewis a ELISA (titration for EC50) and HCT-15 cell surface binding (titration for Kd)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33939e70708d79285891ea6b0c4c0b76
https://doi.org/10.1158/1078-0432.22457460
https://doi.org/10.1158/1078-0432.22457460
Autor:
Lindy G. Durrant, Srinivasan Madhusudan, Abid M. Zaitoun, Ian Spendlove, Tina Parsons, Robert Moss, Philip A. Clarke, Richard S. McIntosh, Mireille Vankemmelbeke, Jia Xin Chua
Supplementary Table 3. containing FG88 glyco-epitope expression on human tumor types. Overview of tumor TMA scoring.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3087324cc688855315a950555ca8b2f3
https://doi.org/10.1158/1078-0432.22457442.v1
https://doi.org/10.1158/1078-0432.22457442.v1
Autor:
Lindy G. Durrant, Srinivasan Madhusudan, Abid M. Zaitoun, Ian Spendlove, Tina Parsons, Robert Moss, Philip A. Clarke, Richard S. McIntosh, Mireille Vankemmelbeke, Jia Xin Chua
Supplementary Table 2. containing IHC scoring of FG88.2 and FG88.7 binding to AMS bio normal human tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e67e0a749b466eb7ef01c4a049332f39
https://doi.org/10.1158/1078-0432.22457445
https://doi.org/10.1158/1078-0432.22457445
Autor:
Lindy G. Durrant, Srinivasan Madhusudan, Abid M. Zaitoun, Ian Spendlove, Tina Parsons, Robert Moss, Philip A. Clarke, Richard S. McIntosh, Mireille Vankemmelbeke, Jia Xin Chua
Supplementary Table 1. containing kinetic and equilibrium binding parameters for FG88.2 and FG88.7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1228393fe427cd9b6b2e500a95464f84
https://doi.org/10.1158/1078-0432.22457448.v1
https://doi.org/10.1158/1078-0432.22457448.v1