Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Ian Sorrell"'
Autor:
Hequn, Li, Joe, Reynolds, Ian, Sorrell, David, Sheffield, Ruth, Pendlington, Richard, Cubberley, Beate, Nicol
Publikováno v:
Toxicology and applied pharmacology. 442
Combined with in vitro bioactivity data, physiologically based kinetic (PBK) models has increasing applications in next generation risk assessment for animal-free safety decision making. A tiered framework of building PBK models for such application
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2b32f06a7079d2121ccdd62866c66913
https://pubmed.ncbi.nlm.nih.gov/35346730
https://pubmed.ncbi.nlm.nih.gov/35346730
Autor:
Michael P. Storm, Rebecca J. Shipley, Dominic P. Williams, John P. Ward, José Domingo Salazar, Pratibha Mistry, Iain Gardner, Andrew D. Scott, Ian Sorrell, Marianne J. Ellis, Sophie L. Regan, Steven D. Webb
Publikováno v:
Journal of Theoretical Biology. 475:25-33
A mathematical model has been developed to assist with the development of a hollow fibre bioreactor (HFB) for hepatotoxicity testing of xenobiotics; specifically, to inform the HFB operating set-up, interpret data from HFB outputs and aid in optimizi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301527e14d31d57efaba7e8008392acc
https://doi.org/10.1016/j.jtbi.2019.05.008
https://doi.org/10.1016/j.jtbi.2019.05.008
Publikováno v:
Pharmaceutical Research. 37
To advance physiologically-based pharmacokinetic modelling of xenobiotic metabolism by integrating metabolic kinetics with percutaneous absorption. Kinetic rate equations were proposed to describe the metabolism of a network of reaction pathways foll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddda69b66fa3ae1100a5d254e8374ecb
https://doi.org/10.1007/s11095-020-02967-w
https://doi.org/10.1007/s11095-020-02967-w
Publikováno v:
Pharmaceutical research. 37(12)
To advance physiologically-based pharmacokinetic modelling of xenobiotic metabolism by integrating metabolic kinetics with percutaneous absorption.Kinetic rate equations were proposed to describe the metabolism of a network of reaction pathways follo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0cac51c6b120c1df24a0ae433aa3d80d
https://pubmed.ncbi.nlm.nih.gov/33175239
https://pubmed.ncbi.nlm.nih.gov/33175239
Autor:
Michael L. Shuler, Delilah F. G. Hendriks, Betty C. Hakkert, Alicia Paini, Peter M.J. Bos, Bart Spee, Marije Strikwold, Ian Sorrell, Paul Jennings, Ans Punt, Huan Yang, Hans Bouwmeester, Bas J. Blaauboer, Minne B. Heringa, Meike van der Zande, Rosalinde Masereeuw, Martijn Rooseboom, Ad A. C. M. Peijnenburg, Mathieu Vinken, Andries D. van der Meer, Sandra Coecke, Nynke I. Kramer, Sibylle Neuhoff
Publikováno v:
ALTEX.
For almost fifteen years, the availability and regulatory acceptance of new approach methodologies (NAMs) to assess the absorption, distribution, metabolism and excretion (ADME/biokinetics) in chemical risk evaluations are a bottleneck. To enhance th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d506975c9be110527fa44b2ace726336
https://doi.org/10.14573/altex.2003242
https://doi.org/10.14573/altex.2003242
Autor:
John A. Troutman, Ian Sorrell, Carine Jacques-Jamin, Eric Fabian, Martina Klaric, Abdulkarim Najjar, Nicola J. Hewitt, H. Duplan, Daniela Lange, Camille Genies, Corie A. Ellison, Andreas Schepky, Sébastien Grégoire
Publikováno v:
Computational Toxicology. 19:100177
The ADME TF aims to develop in silico skin penetration models using in vitro human skin penetration data for 25 chemicals solubilized in wataer. Since there are widely differing opinions on different in silico models, we evaluated 3 open source (Derm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ad2d8852ed4b2606ad2c2f4342adbf9
https://doi.org/10.1016/j.comtox.2021.100177
https://doi.org/10.1016/j.comtox.2021.100177
Publikováno v:
Pharmaceutical Research
Purpose The development of a new two-dimensional (2D) model to predict follicular permeation, with integration into a recently reported multi-scale model of transdermal permeation is presented. Methods The follicular pathway is modelled by diffusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df35896482f65fc06a4aceca7305da7
https://doi.org/10.1007/s11095-017-2209-0
https://doi.org/10.1007/s11095-017-2209-0
Autor:
Przemyslaw Piechota, Beate Nicol, Ruth Pendlington, Maria Teresa Baltazar, Hequn Li, Ian Sorrell, Thomas E. Moxon, Juliette Pickles, Mi-Young Lee
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 63
Next Generation Risk Assessment (NGRA) is a procedure that integrates new approach methodologies (NAMs) to assure safety of a product without generating data from animal testing. One of the major challenges in the application of NGRA to consumer prod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3852f05e4fcf310b611cc43e44c51e16
https://pubmed.ncbi.nlm.nih.gov/31837441
https://pubmed.ncbi.nlm.nih.gov/31837441
Autor:
Eric Fabian, Cathy Lester, Nicola J. Hewitt, Andreas Schepky, Martina Klaric, Corie A. Ellison, Richard Cubberley, Carine Jacques-Jamin, Ian Sorrell, Camille Genies, Joan Eilstein, Helga Rothe, Julien Fernandez, Daniela Lange, Sébastien Grégoire, Hélène Duplan
Publikováno v:
Journal of Applied Toxicology
OECD test guideline 428 compliant protocol using human skin was used to test the penetration of 56 cosmetic‐relevant chemicals. The penetration of finite doses (10 μL/cm2) of chemicals was measured over 24 hours. The dermal delivery (DD) (amount i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83bfad10b3216d84b983776adc50ec80
https://pubmed.ncbi.nlm.nih.gov/31867769
https://pubmed.ncbi.nlm.nih.gov/31867769
Autor:
Richard Cubberley, Bernadett Kalapos-Kovács, Mi-Young Lee, Juliette Pickles, Annabel Rigarlsford, Ian Sorrell, Sue Martin, Krisztina Herédi-Szabó
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S72
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c73fc04d73f82e4d7527fab016a2e7f4
https://doi.org/10.1016/j.dmpk.2020.04.162
https://doi.org/10.1016/j.dmpk.2020.04.162